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growth associated protein 43

Summary

Gene Symbol

GAP43

Organism

Homo sapiens (human)

External Links

NCBI Gene

2596

PubChem

2596

Alliance of Genome Resources

HGNC:4140

Annotation

Keyword

Alternative splicing
Calmodulin-binding
Cell membrane
Cell projection
Cytoplasm
Developmental protein
Differentiation
Growth regulation
Neurogenesis
Palmitate
Phosphoprotein
Reference proteome
Synapse

Proteins

Displaying **all 2** entries
UniProt	Protein Name
P17677	Axonal membrane protein GAP-43 Growth-associated protein 43 Neural phosphoprotein B-50 pp46
Q5U058	Axonal membrane protein GAP-43 Growth-associated protein 43

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	PMID
phospholipase C-activating G protein-coupled receptor signaling pathway	TAS	3272162
response to wounding	TAS	3272162
response to auditory stimulus	IEA
axon choice point recognition	IBA
axon regeneration	IBA

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

G protein-coupled receptor signaling pathway [inference]

phospholipase C-activating G protein-coupled receptor signaling pathway

cell recognition [inference]

neuron recognition [inference]

axon choice point recognition

cellular developmental process [inference]

cell differentiation [inference]

glial cell differentiation [inference]

cell fate commitment

cellular response to stimulus [inference]

cellular response to stress [inference]

neuron projection regeneration [inference]

axon regeneration

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cell projection organization [inference]

plasma membrane bounded cell projection organization [inference]

neuron projection development [inference]

neuron projection regeneration [inference]

axon regeneration

axon development [inference]

axon regeneration

developmental process [inference]

anatomical structure development [inference]

regeneration [inference]

neuron projection regeneration [inference]

axon regeneration

tissue regeneration

cellular developmental process [inference]

cell differentiation [inference]

glial cell differentiation [inference]

cell fate commitment

growth [inference]

developmental growth [inference]

tissue regeneration

response to stimulus [inference]

response to stress [inference]

response to wounding

response to axon injury [inference]

axon regeneration

cellular response to stress [inference]

neuron projection regeneration [inference]

axon regeneration

response to external stimulus [inference]

response to mechanical stimulus [inference]

response to auditory stimulus

response to abiotic stimulus [inference]

response to mechanical stimulus [inference]

response to auditory stimulus

cellular response to stimulus [inference]

cellular response to stress [inference]

neuron projection regeneration [inference]

axon regeneration

biological regulation [inference]

regulation of biological process [inference]

regulation of growth

regulation of cellular process [inference]

signal transduction [inference]

G protein-coupled receptor signaling pathway [inference]

phospholipase C-activating G protein-coupled receptor signaling pathway

regulation of cellular component biogenesis [inference]

regulation of cell projection assembly [inference]

regulation of plasma membrane bounded cell projection assembly [inference]

regulation of filopodium assembly

regulation of organelle assembly [inference]

regulation of postsynaptic specialization assembly

regulation of cellular component organization [inference]

regulation of cell projection organization [inference]

regulation of cell projection assembly [inference]

regulation of plasma membrane bounded cell projection assembly [inference]

regulation of filopodium assembly

regulation of plasma membrane bounded cell projection organization [inference]

regulation of plasma membrane bounded cell projection assembly [inference]

regulation of filopodium assembly

regulation of organelle organization [inference]

regulation of organelle assembly [inference]

regulation of postsynaptic specialization assembly

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
cytoplasm	IBA
plasma membrane	TAS
plasma membrane	IDA
plasma membrane	IBA
postsynaptic density	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytoplasm

membrane [inference]

plasma membrane

plasma membrane region [inference]

cell projection membrane [inference]

filopodium membrane

cell junction [inference]

synapse [inference]

GABA-ergic synapse

growth cone membrane

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

dendrite

perikaryon

organelle [inference]

postsynaptic specialization [inference]

postsynaptic density

presynapse

Displaying **all 5** entries
GO Term	Evidence Code	PMID
phosphatidylserine binding	IBA
protein binding	IPI	30664241 32814053 9139733
calmodulin binding	IBA
lysophosphatidic acid binding	IBA
phosphatidylinositol phosphate binding	IBA

GO Hierarchy

molecular function

binding [inference]

protein binding

calmodulin binding

lipid binding [inference]

phospholipid binding [inference]

phosphatidylserine binding

phosphatidylinositol binding [inference]

phosphatidylinositol phosphate binding

lysophosphatidic acid binding

ion binding [inference]

anion binding [inference]

lysophosphatidic acid binding

modified amino acid binding [inference]

phosphatidylserine binding

carbohydrate derivative binding [inference]

lysophosphatidic acid binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

growth associated protein 43

Functional Category

G: Carbohydrate transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 10** entries
Gene Ontology
axon choice point recognition
axon regeneration
calmodulin binding
cell differentiation
lysophosphatidic acid binding
nervous system development
phosphatidylinositol phosphate binding
phosphatidylserine binding
regulation of growth
tissue regeneration

Displaying **all 5** entries
InterPro
IQ motif, EF-hand binding site
Neuromodulin (GAP-43), C-terminal
Neuromodulin (GAP-43)
Neuromodulin gap junction N-terminal
Neuromodulin, phosphorylation site

Ortholog

Displaying entries **31 - 40** of 77 in total

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Species	Gene ID	Orthologous MAtrix
Ictidomys tridecemlineatus	101963675	ICTTR04004
Ictidomys tridecemlineatus	101972008	ICTTR04004
Chinchilla lanigera	102012561	CHILA08392
Macaca fascicularis	102117213	MACFA27956
Capra hircus	102188801	CAPHI11889
Pelodiscus sinensis	102452598	PELSI15096
Astyanax mexicanus	103041159	ASTMX13512
Erinaceus europaeus	103107513	ERIEU11104
Chlorocebus sabaeus	103228280	CHLSB10716
Carlito syrichta	103257867	CARSF19736

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Acknowledgements