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Guidelines

MIRAGE

charged multivesicular body protein 2B

Summary

Gene Symbol

CHMP2B

Organism

Homo sapiens (human)

External Links

NCBI Gene

25978

PubChem

25978

Alliance of Genome Resources

HGNC:24537

JoGo

CHMP2B

TogoVar

CHMP2B

Annotation

Keyword

3D-structure
Acetylation
Alternative splicing
Amyotrophic lateral sclerosis
Coiled coil
Cytoplasm
Disease variant
Endosome
Membrane
Phosphoprotein
Protein transport
Proteomics identification
Reference proteome

Proteins

Displaying **all 3** entries
UniProt	Protein Name
B2RE76
A0A087WW88
Q9UQN3	CHMP2.5 Chromatin-modifying protein 2b Vacuolar protein sorting-associated protein 2-2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **36 - 37** of 37 in total

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GO Term	Evidence Code	PMID
late endosome to lysosome transport	IMP	17984323
ESCRT III complex disassembly	NAS	20588296

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process [inference]

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway

catabolic process [inference]

cellular catabolic process [inference]

macroautophagy

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

modification-dependent macromolecule catabolic process [inference]

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway

cellular metabolic process [inference]

cellular catabolic process [inference]

macroautophagy

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process [inference]

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

macromolecule catabolic process [inference]

modification-dependent macromolecule catabolic process [inference]

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process [inference]

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process [inference]

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

modification-dependent macromolecule catabolic process [inference]

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway

cellular process [inference]

vesicle-mediated transport [inference]

endosomal transport [inference]

endosome transport via multivesicular body sorting pathway

late endosome to vacuole transport

multivesicular body sorting pathway

endosome transport via multivesicular body sorting pathway

cell cycle process [inference]

cytokinetic process [inference]

mitotic cytokinetic process [inference]

midbody abscission

mitotic cell cycle process [inference]

mitotic metaphase chromosome alignment

mitotic cytokinetic process [inference]

midbody abscission

cellular metabolic process [inference]

cellular catabolic process [inference]

macroautophagy

cellular localization [inference]

intracellular transport [inference]

vacuolar transport [inference]

lysosomal transport [inference]

late endosome to lysosome transport

late endosome to vacuole transport

endosomal transport [inference]

endosome transport via multivesicular body sorting pathway

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport

process utilizing autophagic mechanism [inference]

macroautophagy

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

nucleus organization

vacuole organization [inference]

vacuole fusion [inference]

vesicle fusion with vacuole

vesicle organization [inference]

vesicle fusion [inference]

endosome organization

multivesicular body organization [inference]

multivesicular body assembly

organelle fusion [inference]

organelle membrane fusion [inference]

vesicle fusion [inference]

vacuole fusion [inference]

vesicle fusion with vacuole

organelle assembly [inference]

multivesicular body assembly

cellular component disassembly [inference]

protein-containing complex disassembly [inference]

autophagosome maturation

ESCRT complex disassembly [inference]

ESCRT III complex disassembly

cellular component assembly [inference]

organelle assembly [inference]

multivesicular body assembly

membrane assembly [inference]

nuclear membrane reassembly

protein-containing complex organization [inference]

protein-containing complex disassembly [inference]

autophagosome maturation

ESCRT complex disassembly [inference]

ESCRT III complex disassembly

membrane organization [inference]

plasma membrane organization [inference]

plasma membrane repair

membrane fusion [inference]

organelle membrane fusion [inference]

vesicle fusion [inference]

midbody abscission

membrane assembly [inference]

nuclear membrane reassembly

nuclear membrane organization [inference]

nuclear membrane reassembly

membrane fission

lysosomal membrane organization [inference]

multivesicular body-lysosome fusion

viral process [inference]

viral release from host cell

non-lytic viral release [inference]

viral budding from plasma membrane

viral budding [inference]

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

cognition

homeostatic process [inference]

cellular homeostasis [inference]

neuron cellular homeostasis

biological process involved in interspecies interaction between organisms [inference]

biological process involved in symbiotic interaction [inference]

biological process involved in interaction with host [inference]

movement in host [inference]

exit from host cell [inference]

viral release from host cell

non-lytic viral release [inference]

viral budding from plasma membrane

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport

establishment of localization [inference]

transport [inference]

vesicle-mediated transport [inference]

endosomal transport [inference]

endosome transport via multivesicular body sorting pathway

late endosome to vacuole transport

multivesicular body sorting pathway

endosome transport via multivesicular body sorting pathway

intracellular transport [inference]

vacuolar transport [inference]

lysosomal transport [inference]

late endosome to lysosome transport

late endosome to vacuole transport

endosomal transport [inference]

endosome transport via multivesicular body sorting pathway

organic substance transport [inference]

protein transport

nitrogen compound transport [inference]

protein transport

establishment of protein localization [inference]

protein transport

establishment of localization in cell [inference]

intracellular transport [inference]

vacuolar transport [inference]

lysosomal transport [inference]

late endosome to lysosome transport

late endosome to vacuole transport

endosomal transport [inference]

endosome transport via multivesicular body sorting pathway

establishment of chromosome localization [inference]

metaphase chromosome alignment [inference]

mitotic metaphase chromosome alignment

establishment of organelle localization [inference]

establishment of chromosome localization [inference]

metaphase chromosome alignment [inference]

mitotic metaphase chromosome alignment

organelle localization [inference]

chromosome localization [inference]

establishment of chromosome localization [inference]

metaphase chromosome alignment [inference]

mitotic metaphase chromosome alignment

establishment of organelle localization [inference]

establishment of chromosome localization [inference]

metaphase chromosome alignment [inference]

mitotic metaphase chromosome alignment

cellular localization [inference]

intracellular transport [inference]

vacuolar transport [inference]

lysosomal transport [inference]

late endosome to lysosome transport

late endosome to vacuole transport

endosomal transport [inference]

endosome transport via multivesicular body sorting pathway

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission

regulation of microtubule-based process [inference]

regulation of centrosome cycle [inference]

regulation of centrosome duplication

regulation of microtubule cytoskeleton organization [inference]

regulation of spindle organization [inference]

regulation of mitotic spindle organization [inference]

regulation of mitotic spindle assembly

regulation of spindle assembly [inference]

regulation of mitotic spindle assembly

regulation of cellular component biogenesis [inference]

regulation of organelle assembly [inference]

regulation of spindle assembly [inference]

regulation of mitotic spindle assembly

regulation of cellular component organization [inference]

regulation of organelle organization [inference]

regulation of cytoskeleton organization [inference]

regulation of microtubule cytoskeleton organization [inference]

regulation of spindle organization [inference]

regulation of mitotic spindle organization [inference]

regulation of mitotic spindle assembly

regulation of spindle assembly [inference]

regulation of mitotic spindle assembly

regulation of organelle assembly [inference]

regulation of spindle assembly [inference]

regulation of mitotic spindle assembly

regulation of centrosome cycle [inference]

regulation of centrosome duplication

regulation of synapse organization [inference]

regulation of postsynapse organization

regulation of modification of synaptic structure [inference]

regulation of modification of postsynaptic structure

regulation of cell cycle [inference]

regulation of cell cycle process [inference]

regulation of centrosome cycle [inference]

regulation of centrosome duplication

regulation of spindle organization [inference]

regulation of mitotic spindle organization [inference]

regulation of mitotic spindle assembly

regulation of spindle assembly [inference]

regulation of mitotic spindle assembly

Displaying entries **1 - 5** of 23 in total

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GO Term	Evidence Code	PMID
autophagosome membrane	IDA	17984323
kinetochore	IDA	26040712
ESCRT III complex	NAS	36107470
ESCRT III complex	TAS	20588296 21118109
ESCRT III complex	IDA	24878737

GO Hierarchy

cellular component

protein-containing complex [inference]

ESCRT complex [inference]

ESCRT III complex

membrane protein complex [inference]

ESCRT III complex

nuclear protein-containing complex [inference]

nuclear pore

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

endosome membrane [inference]

late endosome membrane [inference]

multivesicular body membrane

bounding membrane of organelle [inference]

vacuolar membrane [inference]

autophagosome membrane

amphisome membrane

lytic vacuole membrane [inference]

lysosomal membrane

endosome membrane [inference]

late endosome membrane [inference]

multivesicular body membrane

cell junction [inference]

synapse [inference]

glutamatergic synapse

midbody

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

multivesicular body

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

multivesicular body

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

kinetochore

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

multivesicular body

intracellular non-membrane-bounded organelle [inference]

kinetochore

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

postsynaptic specialization [inference]

postsynaptic density

supramolecular complex [inference]

kinetochore

supramolecular polymer [inference]

supramolecular fiber [inference]

polymeric cytoskeletal fiber [inference]

microtubule [inference]

spindle microtubule [inference]

kinetochore microtubule

Displaying **all 3** entries
GO Term	Evidence Code	PMID
protein binding	IPI	16730941 17683935 17928862 21044950 21975012 22046132 23051622 26496610
protein domain specific binding	IPI	17928862
cadherin binding	HDA	25468996

GO Hierarchy

molecular function

binding [inference]

protein binding

protein domain specific binding

cell adhesion molecule binding [inference]

cadherin binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Charged multivesicular body protein

Functional Category

D: Cell cycle control, cell division, chromosome partitioning
Q: Secondary metabolites biosynthesis, transport and catabolism
T: Signal transduction mechanisms

Displaying **all 3** entries
Gene Ontology
endosome transport via multivesicular body sorting pathway
late endosome to vacuole transport
vacuolar transport

Displaying 1 entry
InterPro
Snf7 family

Disease

Disease Ontology

Displaying **all 3** entries
DO ID	Disease Name	Source
DOID:0111227	frontotemporal dementia and/or amyotrophic lateral sclerosis 7	Alliance of Genome Resources
DOID:332	amyotrophic lateral sclerosis	Alliance of Genome Resources
DOID:9255	frontotemporal dementia	Alliance of Genome Resources

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: December 8, 2025