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Guidelines

MIRAGE

amine oxidase copper containing 1

Summary

Gene Symbol

AOC1

Organism

Homo sapiens (human)

External Links

NCBI Gene

26

PubChem

26

Alliance of Genome Resources

HGNC:80

Annotation

Keyword

3D-structure
Alternative splicing
Calcium
Cell membrane
Copper
Direct protein sequencing
Disulfide bond
Glycoprotein
Heparin-binding
Metal-binding
Oxidoreductase
Reference proteome
Secreted
Signal
TPQ

Proteins

Displaying 1 entry
UniProt	Protein Name
P19801	Amiloride-binding protein Amiloride-binding protein 1 Amine oxidase copper domain-containing protein 1 Histaminase Kidney amine oxidase

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 4** entries
GO Term	Evidence Code	PMID
amine metabolic process
putrescine metabolic process	IMP	8144586
putrescine metabolic process	IBA
response to antibiotic

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

amine metabolic process

biogenic amine metabolic process [inference]

polyamine metabolic process [inference]

putrescine metabolic process

organic substance metabolic process [inference]

organonitrogen compound metabolic process [inference]

amine metabolic process

biogenic amine metabolic process [inference]

polyamine metabolic process [inference]

putrescine metabolic process

response to stimulus [inference]

response to chemical [inference]

response to antibiotic

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
extracellular region	TAS
extracellular space	IDA	12072962 8144586 9399025
peroxisome	NAS
plasma membrane	TAS
plasma membrane	IDA	2217167 8144586

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

cell junction [inference]

anchoring junction [inference]

cell-cell junction [inference]

tight junction [inference]

bicellular tight junction

membrane-enclosed lumen [inference]

organelle lumen [inference]

vesicle lumen [inference]

cytoplasmic vesicle lumen [inference]

secretory granule lumen [inference]

specific granule lumen

intracellular organelle lumen [inference]

cytoplasmic vesicle lumen [inference]

secretory granule lumen [inference]

specific granule lumen

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

microbody [inference]

peroxisome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

microbody [inference]

peroxisome

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying entries **1 - 5** of 13 in total

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GO Term	Evidence Code	PMID
copper ion binding	IDA	12072962 19764817
copper ion binding	IBA
calcium ion binding	IDA	12072962 19764817
protein binding	IPI	32296183
primary amine oxidase activity	IDA	8144586

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

oxidoreductase activity, acting on the CH-NH2 group of donors [inference]

oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor [inference]

primary amine oxidase activity

diamine oxidase activity

binding [inference]

protein binding

identical protein binding [inference]

protein homodimerization activity

protein dimerization activity [inference]

protein homodimerization activity

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

calcium ion binding

transition metal ion binding [inference]

copper ion binding

quinone binding

carbohydrate derivative binding [inference]

glycosaminoglycan binding [inference]

heparin binding

sulfur compound binding [inference]

heparin binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Amine oxidase

Functional Category

E: Amino acid transport and metabolism
Q: Secondary metabolites biosynthesis, transport and catabolism
T: Signal transduction mechanisms

Displaying **all 4** entries
Gene Ontology
copper ion binding
metal ion binding
oxidoreductase activity
quinone binding

Displaying **all 6** entries
InterPro
Copper amine oxidase, N-terminal
Copper amine oxidase, N2-terminal
Copper amine oxidase, N3-terminal
Copper amine oxidase, catalytic domain superfamily
Copper amine oxidase, catalytic domain
Copper amine oxidase

Ortholog

Displaying entries **1 - 10** of 78 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	26	Xenbase:XB-GENE-997273
Rattus norvegicus	65029		RATNO31492
Mus musculus	76507	Xenbase:XB-GENE-997273	MOUSE48474
Canis lupus familiaris	475536		CANLF04579
Bos taurus	509751		BOVIN28736
Danio rerio	555401		DANRE26354
Macaca mulatta	714112		MACMU33130
Monodelphis domestica	100017902		MONDO33351
Equus caballus	100063930		HORSE32960
Ornithorhynchus anatinus	100075142		ORNAN05522

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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GlyCosmos Portal v4.4.0

Last updated: December 8, 2025