GlyCosmos Portal

Annotation

Keyword

ATP-binding
Alternative splicing
Cataract
Cobalt
FAD
Kinase
Lyase
Magnesium
Manganese
Metal-binding
Multifunctional enzyme
Phosphoprotein
Proteomics identification
Reference proteome

Proteins

Displaying **all 2** entries
UniProt	Protein Name
A0A140VJH7	Bifunctional ATP-dependent dihydroxyacetone kinase/FAD-AMP lyase (cyclizing)
Q3LXA3	Bifunctional ATP-dependent dihydroxyacetone kinase/FAD-AMP lyase (cyclizing)

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
carbohydrate metabolic process	IDA	16289032 4688871
glycerol catabolic process	IBA
negative regulation of MDA-5 signaling pathway	IDA	17600090
regulation of innate immune response	IDA	16289032
carbohydrate phosphorylation	IDA	4688871

GO Hierarchy

biological process

metabolic process [inference]

catabolic process [inference]

small molecule catabolic process [inference]

alcohol catabolic process [inference]

polyol catabolic process [inference]

alditol catabolic process [inference]

glycerol catabolic process

monosaccharide catabolic process [inference]

hexose catabolic process [inference]

fructose catabolic process [inference]

fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate

organic substance catabolic process [inference]

carbohydrate catabolic process [inference]

alditol catabolic process [inference]

glycerol catabolic process

monosaccharide catabolic process [inference]

hexose catabolic process [inference]

fructose catabolic process [inference]

fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate

organic hydroxy compound catabolic process [inference]

alcohol catabolic process [inference]

polyol catabolic process [inference]

alditol catabolic process [inference]

glycerol catabolic process

cellular metabolic process [inference]

cellular aldehyde metabolic process [inference]

glyceraldehyde-3-phosphate metabolic process [inference]

fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phosphorylation [inference]

carbohydrate phosphorylation

glyceraldehyde-3-phosphate metabolic process [inference]

fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate

organophosphate metabolic process [inference]

glyceraldehyde-3-phosphate metabolic process [inference]

fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate

primary metabolic process [inference]

carbohydrate metabolic process

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

fructose metabolic process [inference]

fructose catabolic process [inference]

fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate

hexose catabolic process [inference]

fructose catabolic process [inference]

fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate

monosaccharide catabolic process [inference]

hexose catabolic process [inference]

fructose catabolic process [inference]

fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate

carbohydrate catabolic process [inference]

alditol catabolic process [inference]

glycerol catabolic process

monosaccharide catabolic process [inference]

hexose catabolic process [inference]

fructose catabolic process [inference]

fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate

alditol metabolic process [inference]

glycerol metabolic process [inference]

glycerol catabolic process

alditol catabolic process [inference]

glycerol catabolic process

carbohydrate phosphorylation

small molecule metabolic process [inference]

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

fructose metabolic process [inference]

fructose catabolic process [inference]

fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate

hexose catabolic process [inference]

fructose catabolic process [inference]

fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate

monosaccharide catabolic process [inference]

hexose catabolic process [inference]

fructose catabolic process [inference]

fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate

alcohol metabolic process [inference]

polyol metabolic process [inference]

alditol metabolic process [inference]

glycerol metabolic process [inference]

glycerol catabolic process

alditol catabolic process [inference]

glycerol catabolic process

polyol catabolic process [inference]

alditol catabolic process [inference]

glycerol catabolic process

alcohol catabolic process [inference]

polyol catabolic process [inference]

alditol catabolic process [inference]

glycerol catabolic process

small molecule catabolic process [inference]

alcohol catabolic process [inference]

polyol catabolic process [inference]

alditol catabolic process [inference]

glycerol catabolic process

monosaccharide catabolic process [inference]

hexose catabolic process [inference]

fructose catabolic process [inference]

fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate

organic substance metabolic process [inference]

carbohydrate metabolic process

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

fructose metabolic process [inference]

fructose catabolic process [inference]

fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate

hexose catabolic process [inference]

fructose catabolic process [inference]

fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate

monosaccharide catabolic process [inference]

hexose catabolic process [inference]

fructose catabolic process [inference]

fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate

carbohydrate catabolic process [inference]

alditol catabolic process [inference]

glycerol catabolic process

monosaccharide catabolic process [inference]

hexose catabolic process [inference]

fructose catabolic process [inference]

fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate

alditol metabolic process [inference]

glycerol metabolic process [inference]

glycerol catabolic process

alditol catabolic process [inference]

glycerol catabolic process

carbohydrate phosphorylation

cellular aldehyde metabolic process [inference]

glyceraldehyde-3-phosphate metabolic process [inference]

fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate

organophosphate metabolic process [inference]

glyceraldehyde-3-phosphate metabolic process [inference]

fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate

carbohydrate derivative metabolic process [inference]

glyceraldehyde-3-phosphate metabolic process [inference]

fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate

organic substance catabolic process [inference]

carbohydrate catabolic process [inference]

alditol catabolic process [inference]

glycerol catabolic process

monosaccharide catabolic process [inference]

hexose catabolic process [inference]

fructose catabolic process [inference]

fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate

organic hydroxy compound catabolic process [inference]

alcohol catabolic process [inference]

polyol catabolic process [inference]

alditol catabolic process [inference]

glycerol catabolic process

organic hydroxy compound metabolic process [inference]

alcohol metabolic process [inference]

polyol metabolic process [inference]

alditol metabolic process [inference]

glycerol metabolic process [inference]

glycerol catabolic process

alditol catabolic process [inference]

glycerol catabolic process

polyol catabolic process [inference]

alditol catabolic process [inference]

glycerol catabolic process

alcohol catabolic process [inference]

polyol catabolic process [inference]

alditol catabolic process [inference]

glycerol catabolic process

organic hydroxy compound catabolic process [inference]

alcohol catabolic process [inference]

polyol catabolic process [inference]

alditol catabolic process [inference]

glycerol catabolic process

cellular process [inference]

cellular metabolic process [inference]

cellular aldehyde metabolic process [inference]

glyceraldehyde-3-phosphate metabolic process [inference]

fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phosphorylation [inference]

carbohydrate phosphorylation

glyceraldehyde-3-phosphate metabolic process [inference]

fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate

organophosphate metabolic process [inference]

glyceraldehyde-3-phosphate metabolic process [inference]

fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

negative regulation of immune system process [inference]

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of MDA-5 signaling pathway

regulation of immune response [inference]

regulation of innate immune response

regulation of pattern recognition receptor signaling pathway [inference]

regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of MDA-5 signaling pathway

regulation of MDA-5 signaling pathway [inference]

negative regulation of MDA-5 signaling pathway

regulation of signaling [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of MDA-5 signaling pathway

regulation of pattern recognition receptor signaling pathway [inference]

regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of MDA-5 signaling pathway

regulation of MDA-5 signaling pathway [inference]

negative regulation of MDA-5 signaling pathway

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of MDA-5 signaling pathway

negative regulation of biological process [inference]

negative regulation of immune system process [inference]

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of MDA-5 signaling pathway

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of MDA-5 signaling pathway

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of MDA-5 signaling pathway

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of MDA-5 signaling pathway

regulation of response to stimulus [inference]

regulation of response to biotic stimulus [inference]

regulation of innate immune response

regulation of pattern recognition receptor signaling pathway [inference]

regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of MDA-5 signaling pathway

regulation of MDA-5 signaling pathway [inference]

negative regulation of MDA-5 signaling pathway

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of MDA-5 signaling pathway

regulation of pattern recognition receptor signaling pathway [inference]

regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of MDA-5 signaling pathway

regulation of MDA-5 signaling pathway [inference]

negative regulation of MDA-5 signaling pathway

regulation of response to external stimulus [inference]

regulation of innate immune response

regulation of pattern recognition receptor signaling pathway [inference]

regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of MDA-5 signaling pathway

regulation of MDA-5 signaling pathway [inference]

negative regulation of MDA-5 signaling pathway

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of MDA-5 signaling pathway

regulation of immune response [inference]

regulation of innate immune response

regulation of pattern recognition receptor signaling pathway [inference]

regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of MDA-5 signaling pathway

regulation of MDA-5 signaling pathway [inference]

negative regulation of MDA-5 signaling pathway

regulation of response to stress [inference]

regulation of defense response [inference]

regulation of innate immune response

regulation of pattern recognition receptor signaling pathway [inference]

regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of MDA-5 signaling pathway

regulation of MDA-5 signaling pathway [inference]

negative regulation of MDA-5 signaling pathway

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of MDA-5 signaling pathway

regulation of pattern recognition receptor signaling pathway [inference]

regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of MDA-5 signaling pathway

regulation of MDA-5 signaling pathway [inference]

negative regulation of MDA-5 signaling pathway

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of MDA-5 signaling pathway

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of MDA-5 signaling pathway

Displaying **all 4** entries
GO Term	Evidence Code	PMID
nucleus	HDA	21630459
cytosol	TAS
cytosol	IBA
extracellular exosome	HDA	19056867 23533145

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytosol

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

nucleus

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
glycerone kinase activity	IDA	16289032 32004446 4688871
glycerone kinase activity	IBA
protein binding	IPI	17600090 25416956
ATP binding	IEA
FAD-AMP lyase (cyclizing) activity	IDA	16289032

GO Hierarchy

molecular function

catalytic activity [inference]

cyclase activity [inference]

FAD-AMP lyase (cyclizing) activity

transferase activity [inference]

transferase activity, transferring phosphorus-containing groups [inference]

kinase activity [inference]

phosphotransferase activity, alcohol group as acceptor [inference]

lyase activity [inference]

phosphorus-oxygen lyase activity [inference]

FAD-AMP lyase (cyclizing) activity

binding [inference]

protein binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

cation binding [inference]

metal ion binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

Gene Ontology information from NCBI Gene and UniProt.

KEGG BRITE Database

Orthology

K00863

Name

triose/dihydroxyacetone kinase / FAD-AMP lyase (cyclizing) [EC:2.7.1.28 2.7.1.29 4.6.1.15]

References

Rhea

RHEA:15773

dihydroxyacetone + ATP

H⁺ + ADP + dihydroxyacetone phosphate

Enzyme

2.7.1.29

PMID

RHEA:13729

FAD

H⁺ + AMP + riboflavin cyclic-4',5'-phosphate

Enzyme

4.6.1.15

PMID

RHEA:13941

D-glyceraldehyde + ATP

H⁺ + ADP + D-glyceraldehyde 3-phosphate

Enzyme

2.7.1.28

PMID

Disease

The Human Phenotype Ontology

Displaying entries **1 - 10** of 27 in total

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HPO ID	HPO Term
HP:0000007	Autosomal recessive inheritance
HP:0000486	Strabismus
HP:0000501	Glaucoma
HP:0000512	Abnormal electroretinogram
HP:0000518	Cataract
HP:0000545	Myopia
HP:0000568	Microphthalmia
HP:0000639	Nystagmus
HP:0000750	Delayed speech and language development
HP:0001131	Corneal dystrophy

Displaying **all 2** entries
Disease ID	Disease Name
ORPHA:1369	Sengers syndrome
OMIM:618805	triokinase and FMN cyclase deficiency syndrome

PubChem Disease

MedGen Diseases

Triokinase and FMN cyclase deficiency syndrome

OMIM Phenotypes

TRIOKINASE AND FMN CYCLASE DEFICIENCY SYNDROME; TKFCD

Gene-Disease-Co-Occurrences-in-Literature (PubChem)

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP006684
Gene Name: dihydroxyacetone kinase 2 homolog (S. cerevisiae)

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Guidelines

Summary

External Links

Annotation

KEGG BRITE Database

PubChem Disease

LIPID MAPS Gene / Proteome Database

International Collaboration

Acknowledgements