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SUMO specific peptidase 6

Summary

Gene Symbol

SENP6

Organism

Homo sapiens (human)

External Links

NCBI Gene

26054

PubChem

26054

Alliance of Genome Resources

HGNC:20944

JoGo

SENP6

TogoVar

SENP6

Annotation

Keyword

Alternative splicing
Isopeptide bond
Nucleus
Phosphoprotein
Protease
Proteomics identification
Reference proteome
Thiol protease
Ubl conjugation
Ubl conjugation pathway

Proteins

Displaying **all 3** entries
UniProt	Protein Name
B3KMM0
Q9GZR1	SUMO-1-specific protease 1 Sentrin/SUMO-specific protease SENP6
F8W6D9

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 9 in total

1

2

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GO Term	Evidence Code	PMID
proteolysis	IEA
protein sumoylation	IEA
protein desumoylation	IMP	20212317
protein desumoylation	IBA
protein modification by small protein removal	IDA	20212317

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis

protein modification process [inference]

peptidyl-amino acid modification [inference]

peptidyl-lysine modification [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein sumoylation

protein modification by small protein removal

protein desumoylation

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis

protein modification process [inference]

peptidyl-amino acid modification [inference]

peptidyl-lysine modification [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein sumoylation

protein modification by small protein removal

protein desumoylation

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

proteolysis

protein modification process [inference]

peptidyl-amino acid modification [inference]

peptidyl-lysine modification [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein sumoylation

protein modification by small protein removal

protein desumoylation

macromolecule modification [inference]

protein modification process [inference]

peptidyl-amino acid modification [inference]

peptidyl-lysine modification [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein sumoylation

protein modification by small protein removal

protein desumoylation

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis

protein modification process [inference]

peptidyl-amino acid modification [inference]

peptidyl-lysine modification [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein sumoylation

protein modification by small protein removal

protein desumoylation

biological regulation [inference]

regulation of biological process [inference]

regulation of cellular process [inference]

regulation of microtubule-based process [inference]

regulation of microtubule cytoskeleton organization [inference]

regulation of spindle organization [inference]

regulation of spindle assembly

regulation of cellular component biogenesis [inference]

regulation of protein-containing complex assembly [inference]

regulation of centromere complex assembly [inference]

regulation of kinetochore assembly

regulation of organelle assembly [inference]

regulation of cellular component organization [inference]

regulation of organelle organization [inference]

regulation of chromosome organization [inference]

regulation of centromere complex assembly [inference]

regulation of kinetochore assembly

regulation of cytoskeleton organization [inference]

regulation of microtubule cytoskeleton organization [inference]

regulation of spindle organization [inference]

regulation of spindle assembly

regulation of organelle assembly [inference]

regulation of protein-containing complex assembly [inference]

regulation of centromere complex assembly [inference]

regulation of kinetochore assembly

regulation of cell cycle [inference]

regulation of cell cycle process [inference]

regulation of spindle organization [inference]

regulation of spindle assembly

Displaying **all 4** entries
GO Term	Evidence Code	PMID
nucleus	IBA
nucleoplasm	IDA
cytoplasm	IBA
cytosol	IDA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

Displaying **all 3** entries
GO Term	Evidence Code	PMID
protein binding	IPI	20212317
SUMO-specific endopeptidase activity	IMP	20212317
SUMO-specific endopeptidase activity	IBA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity [inference]

endopeptidase activity [inference]

cysteine-type endopeptidase activity [inference]

ubiquitin-like protein-specific endopeptidase activity [inference]

SUMO-specific endopeptidase activity

cysteine-type peptidase activity [inference]

cysteine-type endopeptidase activity [inference]

ubiquitin-like protein-specific endopeptidase activity [inference]

SUMO-specific endopeptidase activity

ubiquitin-like protein peptidase activity [inference]

ubiquitin-like protein-specific endopeptidase activity [inference]

SUMO-specific endopeptidase activity

catalytic activity, acting on a protein [inference]

peptidase activity [inference]

endopeptidase activity [inference]

cysteine-type endopeptidase activity [inference]

ubiquitin-like protein-specific endopeptidase activity [inference]

SUMO-specific endopeptidase activity

cysteine-type peptidase activity [inference]

cysteine-type endopeptidase activity [inference]

ubiquitin-like protein-specific endopeptidase activity [inference]

SUMO-specific endopeptidase activity

ubiquitin-like protein peptidase activity [inference]

ubiquitin-like protein-specific endopeptidase activity [inference]

SUMO-specific endopeptidase activity

binding [inference]

protein binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Protease

Functional Category

L: Replication, recombination and repair
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
proteolysis

Displaying **all 2** entries
InterPro
Papain-like cysteine peptidase superfamily
Ulp1 protease family, C-terminal catalytic domain

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Last updated: April 6, 2026

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