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abhydrolase domain containing 12, lysophospholipase

Summary

Gene Symbol

ABHD12

Aliases

ABHD12A
BEM46L2
DKFZP434P106
dJ965G21.2

Organism

Homo sapiens (human)

External Links

NCBI Gene

26090

HGNC

15868

PubChem

26090

Alliance of Genome Resources

HGNC:15868

Annotation

Keyword

Alternative splicing
Cataract
Deafness
Disease variant
Endoplasmic reticulum
Glycoprotein
Hydrolase
Lipid metabolism
Neuropathy
Reference proteome
Retinitis pigmentosa
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q8N2K0	2-arachidonoylglycerol hydrolase ABHD12 Abhydrolase domain-containing protein 12 Monoacylglycerol lipase ABHD12 Oxidized phosphatidylserine lipase ABHD12

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 10 in total

1

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GO Term	Evidence Code	PMID
monoacylglycerol catabolic process	IBA IDA	25290914 30237167
protein depalmitoylation	IEA
phospholipid catabolic process	IDA	30237167
glycerophospholipid catabolic process	IDA	25290914
arachidonic acid metabolic process	TAS

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

cellular modified amino acid metabolic process [inference]

phosphatidylserine metabolic process [inference]

phosphatidylserine catabolic process

cellular modified amino acid catabolic process [inference]

phosphatidylserine catabolic process

protein metabolic process [inference]

protein catabolic process [inference]

lipoprotein catabolic process [inference]

protein depalmitoylation

protein modification process [inference]

protein deacylation [inference]

protein depalmitoylation

lipoprotein metabolic process [inference]

lipoprotein catabolic process [inference]

protein depalmitoylation

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

lipoprotein catabolic process [inference]

protein depalmitoylation

cellular modified amino acid catabolic process [inference]

phosphatidylserine catabolic process

catabolic process [inference]

cellular catabolic process [inference]

cellular lipid catabolic process [inference]

phospholipid catabolic process

glycerophospholipid catabolic process

phosphatidylserine catabolic process

neutral lipid catabolic process [inference]

acylglycerol catabolic process

monoacylglycerol catabolic process

glycerolipid catabolic process [inference]

acylglycerol catabolic process

monoacylglycerol catabolic process

glycerophospholipid catabolic process

phosphatidylserine catabolic process

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

lipoprotein catabolic process [inference]

protein depalmitoylation

lipid catabolic process [inference]

cellular lipid catabolic process [inference]

phospholipid catabolic process

glycerophospholipid catabolic process

phosphatidylserine catabolic process

neutral lipid catabolic process [inference]

acylglycerol catabolic process

monoacylglycerol catabolic process

glycerolipid catabolic process [inference]

acylglycerol catabolic process

monoacylglycerol catabolic process

glycerophospholipid catabolic process

phosphatidylserine catabolic process

organophosphate catabolic process [inference]

phospholipid catabolic process

glycerophospholipid catabolic process

phosphatidylserine catabolic process

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

lipoprotein catabolic process [inference]

protein depalmitoylation

cellular modified amino acid catabolic process [inference]

phosphatidylserine catabolic process

cellular metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

icosanoid metabolic process [inference]

arachidonic acid metabolic process

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

arachidonic acid metabolic process

unsaturated fatty acid metabolic process [inference]

arachidonic acid metabolic process

cellular modified amino acid metabolic process [inference]

phosphatidylserine metabolic process [inference]

phosphatidylserine catabolic process

cellular modified amino acid catabolic process [inference]

phosphatidylserine catabolic process

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylserine metabolic process [inference]

phosphatidylserine catabolic process

glycerophospholipid catabolic process

phosphatidylserine catabolic process

phospholipid catabolic process

glycerophospholipid catabolic process

phosphatidylserine catabolic process

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylserine metabolic process [inference]

phosphatidylserine catabolic process

glycerophospholipid catabolic process

phosphatidylserine catabolic process

phospholipid catabolic process

glycerophospholipid catabolic process

phosphatidylserine catabolic process

organophosphate catabolic process [inference]

phospholipid catabolic process

glycerophospholipid catabolic process

phosphatidylserine catabolic process

cellular catabolic process [inference]

cellular lipid catabolic process [inference]

phospholipid catabolic process

glycerophospholipid catabolic process

phosphatidylserine catabolic process

neutral lipid catabolic process [inference]

acylglycerol catabolic process

monoacylglycerol catabolic process

glycerolipid catabolic process [inference]

acylglycerol catabolic process

monoacylglycerol catabolic process

glycerophospholipid catabolic process

phosphatidylserine catabolic process

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

arachidonic acid metabolic process

unsaturated fatty acid metabolic process [inference]

arachidonic acid metabolic process

neutral lipid metabolic process [inference]

acylglycerol metabolic process [inference]

monoacylglycerol metabolic process [inference]

monoacylglycerol catabolic process

acylglycerol catabolic process

monoacylglycerol catabolic process

neutral lipid catabolic process [inference]

acylglycerol catabolic process

monoacylglycerol catabolic process

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylserine metabolic process [inference]

phosphatidylserine catabolic process

glycerophospholipid catabolic process

phosphatidylserine catabolic process

phospholipid catabolic process

glycerophospholipid catabolic process

phosphatidylserine catabolic process

cellular lipid catabolic process [inference]

phospholipid catabolic process

glycerophospholipid catabolic process

phosphatidylserine catabolic process

neutral lipid catabolic process [inference]

acylglycerol catabolic process

monoacylglycerol catabolic process

glycerolipid catabolic process [inference]

acylglycerol catabolic process

monoacylglycerol catabolic process

glycerophospholipid catabolic process

phosphatidylserine catabolic process

glycerolipid metabolic process [inference]

acylglycerol metabolic process [inference]

monoacylglycerol metabolic process [inference]

monoacylglycerol catabolic process

acylglycerol catabolic process

monoacylglycerol catabolic process

glycerophospholipid metabolic process [inference]

phosphatidylserine metabolic process [inference]

phosphatidylserine catabolic process

glycerophospholipid catabolic process

phosphatidylserine catabolic process

glycerolipid catabolic process [inference]

acylglycerol catabolic process

monoacylglycerol catabolic process

glycerophospholipid catabolic process

phosphatidylserine catabolic process

primary metabolic process [inference]

lipid metabolic process [inference]

lipid catabolic process [inference]

cellular lipid catabolic process [inference]

phospholipid catabolic process

glycerophospholipid catabolic process

phosphatidylserine catabolic process

neutral lipid catabolic process [inference]

acylglycerol catabolic process

monoacylglycerol catabolic process

glycerolipid catabolic process [inference]

acylglycerol catabolic process

monoacylglycerol catabolic process

glycerophospholipid catabolic process

phosphatidylserine catabolic process

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

arachidonic acid metabolic process

unsaturated fatty acid metabolic process [inference]

arachidonic acid metabolic process

neutral lipid metabolic process [inference]

acylglycerol metabolic process [inference]

monoacylglycerol metabolic process [inference]

monoacylglycerol catabolic process

acylglycerol catabolic process

monoacylglycerol catabolic process

neutral lipid catabolic process [inference]

acylglycerol catabolic process

monoacylglycerol catabolic process

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylserine metabolic process [inference]

phosphatidylserine catabolic process

glycerophospholipid catabolic process

phosphatidylserine catabolic process

phospholipid catabolic process

glycerophospholipid catabolic process

phosphatidylserine catabolic process

cellular lipid catabolic process [inference]

phospholipid catabolic process

glycerophospholipid catabolic process

phosphatidylserine catabolic process

neutral lipid catabolic process [inference]

acylglycerol catabolic process

monoacylglycerol catabolic process

glycerolipid catabolic process [inference]

acylglycerol catabolic process

monoacylglycerol catabolic process

glycerophospholipid catabolic process

phosphatidylserine catabolic process

glycerolipid metabolic process [inference]

acylglycerol metabolic process [inference]

monoacylglycerol metabolic process [inference]

monoacylglycerol catabolic process

acylglycerol catabolic process

monoacylglycerol catabolic process

glycerophospholipid metabolic process [inference]

phosphatidylserine metabolic process [inference]

phosphatidylserine catabolic process

glycerophospholipid catabolic process

phosphatidylserine catabolic process

glycerolipid catabolic process [inference]

acylglycerol catabolic process

monoacylglycerol catabolic process

glycerophospholipid catabolic process

phosphatidylserine catabolic process

protein metabolic process [inference]

protein catabolic process [inference]

lipoprotein catabolic process [inference]

protein depalmitoylation

protein modification process [inference]

protein deacylation [inference]

protein depalmitoylation

lipoprotein metabolic process [inference]

lipoprotein catabolic process [inference]

protein depalmitoylation

small molecule metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

icosanoid metabolic process [inference]

arachidonic acid metabolic process

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

arachidonic acid metabolic process

unsaturated fatty acid metabolic process [inference]

arachidonic acid metabolic process

organic substance metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

icosanoid metabolic process [inference]

arachidonic acid metabolic process

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

arachidonic acid metabolic process

unsaturated fatty acid metabolic process [inference]

arachidonic acid metabolic process

lipid metabolic process [inference]

lipid catabolic process [inference]

cellular lipid catabolic process [inference]

phospholipid catabolic process

glycerophospholipid catabolic process

phosphatidylserine catabolic process

neutral lipid catabolic process [inference]

acylglycerol catabolic process

monoacylglycerol catabolic process

glycerolipid catabolic process [inference]

acylglycerol catabolic process

monoacylglycerol catabolic process

glycerophospholipid catabolic process

phosphatidylserine catabolic process

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

arachidonic acid metabolic process

unsaturated fatty acid metabolic process [inference]

arachidonic acid metabolic process

neutral lipid metabolic process [inference]

acylglycerol metabolic process [inference]

monoacylglycerol metabolic process [inference]

monoacylglycerol catabolic process

acylglycerol catabolic process

monoacylglycerol catabolic process

neutral lipid catabolic process [inference]

acylglycerol catabolic process

monoacylglycerol catabolic process

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylserine metabolic process [inference]

phosphatidylserine catabolic process

glycerophospholipid catabolic process

phosphatidylserine catabolic process

phospholipid catabolic process

glycerophospholipid catabolic process

phosphatidylserine catabolic process

cellular lipid catabolic process [inference]

phospholipid catabolic process

glycerophospholipid catabolic process

phosphatidylserine catabolic process

neutral lipid catabolic process [inference]

acylglycerol catabolic process

monoacylglycerol catabolic process

glycerolipid catabolic process [inference]

acylglycerol catabolic process

monoacylglycerol catabolic process

glycerophospholipid catabolic process

phosphatidylserine catabolic process

glycerolipid metabolic process [inference]

acylglycerol metabolic process [inference]

monoacylglycerol metabolic process [inference]

monoacylglycerol catabolic process

acylglycerol catabolic process

monoacylglycerol catabolic process

glycerophospholipid metabolic process [inference]

phosphatidylserine metabolic process [inference]

phosphatidylserine catabolic process

glycerophospholipid catabolic process

phosphatidylserine catabolic process

glycerolipid catabolic process [inference]

acylglycerol catabolic process

monoacylglycerol catabolic process

glycerophospholipid catabolic process

phosphatidylserine catabolic process

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylserine metabolic process [inference]

phosphatidylserine catabolic process

glycerophospholipid catabolic process

phosphatidylserine catabolic process

phospholipid catabolic process

glycerophospholipid catabolic process

phosphatidylserine catabolic process

organophosphate catabolic process [inference]

phospholipid catabolic process

glycerophospholipid catabolic process

phosphatidylserine catabolic process

macromolecule metabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

lipoprotein catabolic process [inference]

protein depalmitoylation

protein metabolic process [inference]

protein catabolic process [inference]

lipoprotein catabolic process [inference]

protein depalmitoylation

protein modification process [inference]

protein deacylation [inference]

protein depalmitoylation

lipoprotein metabolic process [inference]

lipoprotein catabolic process [inference]

protein depalmitoylation

macromolecule modification [inference]

protein modification process [inference]

protein deacylation [inference]

protein depalmitoylation

macromolecule deacylation [inference]

protein deacylation [inference]

protein depalmitoylation

macromolecule depalmitoylation [inference]

protein depalmitoylation

olefinic compound metabolic process [inference]

arachidonic acid metabolic process

organonitrogen compound metabolic process [inference]

cellular modified amino acid metabolic process [inference]

phosphatidylserine metabolic process [inference]

phosphatidylserine catabolic process

cellular modified amino acid catabolic process [inference]

phosphatidylserine catabolic process

protein metabolic process [inference]

protein catabolic process [inference]

lipoprotein catabolic process [inference]

protein depalmitoylation

protein modification process [inference]

protein deacylation [inference]

protein depalmitoylation

lipoprotein metabolic process [inference]

lipoprotein catabolic process [inference]

protein depalmitoylation

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

lipoprotein catabolic process [inference]

protein depalmitoylation

cellular modified amino acid catabolic process [inference]

phosphatidylserine catabolic process

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

lipoprotein catabolic process [inference]

protein depalmitoylation

lipid catabolic process [inference]

cellular lipid catabolic process [inference]

phospholipid catabolic process

glycerophospholipid catabolic process

phosphatidylserine catabolic process

neutral lipid catabolic process [inference]

acylglycerol catabolic process

monoacylglycerol catabolic process

glycerolipid catabolic process [inference]

acylglycerol catabolic process

monoacylglycerol catabolic process

glycerophospholipid catabolic process

phosphatidylserine catabolic process

organophosphate catabolic process [inference]

phospholipid catabolic process

glycerophospholipid catabolic process

phosphatidylserine catabolic process

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

lipoprotein catabolic process [inference]

protein depalmitoylation

cellular modified amino acid catabolic process [inference]

phosphatidylserine catabolic process

cellular process [inference]

cellular metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

icosanoid metabolic process [inference]

arachidonic acid metabolic process

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

arachidonic acid metabolic process

unsaturated fatty acid metabolic process [inference]

arachidonic acid metabolic process

cellular modified amino acid metabolic process [inference]

phosphatidylserine metabolic process [inference]

phosphatidylserine catabolic process

cellular modified amino acid catabolic process [inference]

phosphatidylserine catabolic process

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylserine metabolic process [inference]

phosphatidylserine catabolic process

glycerophospholipid catabolic process

phosphatidylserine catabolic process

phospholipid catabolic process

glycerophospholipid catabolic process

phosphatidylserine catabolic process

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylserine metabolic process [inference]

phosphatidylserine catabolic process

glycerophospholipid catabolic process

phosphatidylserine catabolic process

phospholipid catabolic process

glycerophospholipid catabolic process

phosphatidylserine catabolic process

organophosphate catabolic process [inference]

phospholipid catabolic process

glycerophospholipid catabolic process

phosphatidylserine catabolic process

cellular catabolic process [inference]

cellular lipid catabolic process [inference]

phospholipid catabolic process

glycerophospholipid catabolic process

phosphatidylserine catabolic process

neutral lipid catabolic process [inference]

acylglycerol catabolic process

monoacylglycerol catabolic process

glycerolipid catabolic process [inference]

acylglycerol catabolic process

monoacylglycerol catabolic process

glycerophospholipid catabolic process

phosphatidylserine catabolic process

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

arachidonic acid metabolic process

unsaturated fatty acid metabolic process [inference]

arachidonic acid metabolic process

neutral lipid metabolic process [inference]

acylglycerol metabolic process [inference]

monoacylglycerol metabolic process [inference]

monoacylglycerol catabolic process

acylglycerol catabolic process

monoacylglycerol catabolic process

neutral lipid catabolic process [inference]

acylglycerol catabolic process

monoacylglycerol catabolic process

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylserine metabolic process [inference]

phosphatidylserine catabolic process

glycerophospholipid catabolic process

phosphatidylserine catabolic process

phospholipid catabolic process

glycerophospholipid catabolic process

phosphatidylserine catabolic process

cellular lipid catabolic process [inference]

phospholipid catabolic process

glycerophospholipid catabolic process

phosphatidylserine catabolic process

neutral lipid catabolic process [inference]

acylglycerol catabolic process

monoacylglycerol catabolic process

glycerolipid catabolic process [inference]

acylglycerol catabolic process

monoacylglycerol catabolic process

glycerophospholipid catabolic process

phosphatidylserine catabolic process

glycerolipid metabolic process [inference]

acylglycerol metabolic process [inference]

monoacylglycerol metabolic process [inference]

monoacylglycerol catabolic process

acylglycerol catabolic process

monoacylglycerol catabolic process

glycerophospholipid metabolic process [inference]

phosphatidylserine metabolic process [inference]

phosphatidylserine catabolic process

glycerophospholipid catabolic process

phosphatidylserine catabolic process

glycerolipid catabolic process [inference]

acylglycerol catabolic process

monoacylglycerol catabolic process

glycerophospholipid catabolic process

phosphatidylserine catabolic process

multicellular organismal process [inference]

behavior [inference]

locomotory behavior [inference]

adult locomotory behavior [inference]

adult walking behavior

walking behavior [inference]

adult walking behavior

adult behavior [inference]

adult locomotory behavior [inference]

adult walking behavior

response to stimulus [inference]

response to external stimulus [inference]

response to mechanical stimulus [inference]

response to auditory stimulus

response to abiotic stimulus [inference]

response to mechanical stimulus [inference]

response to auditory stimulus

biological regulation [inference]

regulation of biological process [inference]

regulation of response to stimulus [inference]

regulation of response to external stimulus [inference]

regulation of inflammatory response

regulation of response to stress [inference]

regulation of defense response [inference]

regulation of inflammatory response

Displaying **all 5** entries
GO Term	Evidence Code	PMID
dendrite cytoplasm	IEA
AMPA glutamate receptor complex	IEA
plasma membrane	TAS
membrane	ISS
endoplasmic reticulum membrane	IBA IDA	30237167

GO Hierarchy

cellular component

protein-containing complex [inference]

receptor complex [inference]

plasma membrane signaling receptor complex [inference]

neurotransmitter receptor complex [inference]

ionotropic glutamate receptor complex [inference]

AMPA glutamate receptor complex

membrane protein complex [inference]

plasma membrane protein complex [inference]

plasma membrane signaling receptor complex [inference]

neurotransmitter receptor complex [inference]

ionotropic glutamate receptor complex [inference]

AMPA glutamate receptor complex

transmembrane transporter complex [inference]

monoatomic ion channel complex [inference]

ionotropic glutamate receptor complex [inference]

AMPA glutamate receptor complex

transporter complex [inference]

transmembrane transporter complex [inference]

monoatomic ion channel complex [inference]

ionotropic glutamate receptor complex [inference]

AMPA glutamate receptor complex

cellular anatomical entity [inference]

cytoplasm [inference]

cytoplasmic region [inference]

plasma membrane bounded cell projection cytoplasm [inference]

neuron projection cytoplasm [inference]

dendrite cytoplasm

membrane

plasma membrane

organelle membrane [inference]

endoplasmic reticulum membrane

Displaying **all 4** entries
GO Term	Evidence Code	PMID
lysophospholipase activity	IBA IDA	25290914 30237167
phospholipase activity	IDA	30643283
acylglycerol lipase activity	IBA IDA TAS	22969151 25290914 30237167
palmitoyl-(protein) hydrolase activity	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on ester bonds [inference]

lipase activity [inference]

phospholipase activity

lysophospholipase activity

acylglycerol lipase activity

thiolester hydrolase activity [inference]

palmitoyl-(protein) hydrolase activity

carboxylic ester hydrolase activity [inference]

palmitoyl hydrolase activity [inference]

palmitoyl-(protein) hydrolase activity

catalytic activity, acting on a protein [inference]

palmitoyl-(protein) hydrolase activity

Gene Ontology information from NCBI Gene and UniProt.

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0080181	PHARC syndrome	Alliance of Genome Resources

The Human Phenotype Ontology

Displaying entries **1 - 10** of 27 in total

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HPO ID	HPO Term
HP:0000007	Autosomal recessive inheritance
HP:0000407	Sensorineural hearing impairment
HP:0000510	Rod-cone dystrophy
HP:0000518	Cataract
HP:0000523	Subcapsular cataract
HP:0000639	Nystagmus
HP:0000648	Optic atrophy
HP:0000762	Decreased nerve conduction velocity
HP:0001251	Ataxia
HP:0001257	Spasticity