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integrator complex subunit 1

Summary

Gene Symbol

INTS1

Organism

Homo sapiens (human)

External Links

NCBI Gene

26173

PubChem

26173

Alliance of Genome Resources

HGNC:24555

JoGo

INTS1

TogoVar

INTS1

Annotation

Keyword

3D-structure
Acetylation
Disease variant
Intellectual disability
Nucleus
Phosphoprotein
Proteomics identification
Reference proteome
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q8N201

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 7 in total

1

2

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GO Term	Evidence Code	PMID
inner cell mass cell proliferation	IEA
embryo implantation	IEA
snRNA processing	NAS	16239144
snRNA processing	IDA	16239144
regulation of transcription elongation by RNA polymerase II	NAS	32697989

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

RNA 3'-end processing [inference]

snRNA 3'-end processing [inference]

U2 snRNA 3'-end processing

ncRNA processing [inference]

snRNA processing

snRNA 3'-end processing [inference]

U2 snRNA 3'-end processing

ncRNA metabolic process [inference]

snRNA metabolic process [inference]

snRNA processing

snRNA 3'-end processing [inference]

U2 snRNA 3'-end processing

ncRNA processing [inference]

snRNA processing

snRNA 3'-end processing [inference]

U2 snRNA 3'-end processing

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

RNA 3'-end processing [inference]

snRNA 3'-end processing [inference]

U2 snRNA 3'-end processing

ncRNA processing [inference]

snRNA processing

snRNA 3'-end processing [inference]

U2 snRNA 3'-end processing

ncRNA metabolic process [inference]

snRNA metabolic process [inference]

snRNA processing

snRNA 3'-end processing [inference]

U2 snRNA 3'-end processing

ncRNA processing [inference]

snRNA processing

snRNA 3'-end processing [inference]

U2 snRNA 3'-end processing

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

RNA 3'-end processing [inference]

snRNA 3'-end processing [inference]

U2 snRNA 3'-end processing

ncRNA processing [inference]

snRNA processing

snRNA 3'-end processing [inference]

U2 snRNA 3'-end processing

ncRNA metabolic process [inference]

snRNA metabolic process [inference]

snRNA processing

snRNA 3'-end processing [inference]

U2 snRNA 3'-end processing

ncRNA processing [inference]

snRNA processing

snRNA 3'-end processing [inference]

U2 snRNA 3'-end processing

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

RNA 3'-end processing [inference]

snRNA 3'-end processing [inference]

U2 snRNA 3'-end processing

ncRNA processing [inference]

snRNA processing

snRNA 3'-end processing [inference]

U2 snRNA 3'-end processing

ncRNA metabolic process [inference]

snRNA metabolic process [inference]

snRNA processing

snRNA 3'-end processing [inference]

U2 snRNA 3'-end processing

ncRNA processing [inference]

snRNA processing

snRNA 3'-end processing [inference]

U2 snRNA 3'-end processing

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

RNA 3'-end processing [inference]

snRNA 3'-end processing [inference]

U2 snRNA 3'-end processing

ncRNA processing [inference]

snRNA processing

snRNA 3'-end processing [inference]

U2 snRNA 3'-end processing

ncRNA metabolic process [inference]

snRNA metabolic process [inference]

snRNA processing

snRNA 3'-end processing [inference]

U2 snRNA 3'-end processing

ncRNA processing [inference]

snRNA processing

snRNA 3'-end processing [inference]

U2 snRNA 3'-end processing

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

RNA 3'-end processing [inference]

snRNA 3'-end processing [inference]

U2 snRNA 3'-end processing

ncRNA processing [inference]

snRNA processing

snRNA 3'-end processing [inference]

U2 snRNA 3'-end processing

ncRNA metabolic process [inference]

snRNA metabolic process [inference]

snRNA processing

snRNA 3'-end processing [inference]

U2 snRNA 3'-end processing

ncRNA processing [inference]

snRNA processing

snRNA 3'-end processing [inference]

U2 snRNA 3'-end processing

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

RNA 3'-end processing [inference]

snRNA 3'-end processing [inference]

U2 snRNA 3'-end processing

ncRNA processing [inference]

snRNA processing

snRNA 3'-end processing [inference]

U2 snRNA 3'-end processing

ncRNA metabolic process [inference]

snRNA metabolic process [inference]

snRNA processing

snRNA 3'-end processing [inference]

U2 snRNA 3'-end processing

ncRNA processing [inference]

snRNA processing

snRNA 3'-end processing [inference]

U2 snRNA 3'-end processing

cellular process [inference]

cell population proliferation [inference]

inner cell mass cell proliferation

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

RNA 3'-end processing [inference]

snRNA 3'-end processing [inference]

U2 snRNA 3'-end processing

ncRNA processing [inference]

snRNA processing

snRNA 3'-end processing [inference]

U2 snRNA 3'-end processing

ncRNA metabolic process [inference]

snRNA metabolic process [inference]

snRNA processing

snRNA 3'-end processing [inference]

U2 snRNA 3'-end processing

ncRNA processing [inference]

snRNA processing

snRNA 3'-end processing [inference]

U2 snRNA 3'-end processing

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

RNA 3'-end processing [inference]

snRNA 3'-end processing [inference]

U2 snRNA 3'-end processing

ncRNA processing [inference]

snRNA processing

snRNA 3'-end processing [inference]

U2 snRNA 3'-end processing

ncRNA metabolic process [inference]

snRNA metabolic process [inference]

snRNA processing

snRNA 3'-end processing [inference]

U2 snRNA 3'-end processing

ncRNA processing [inference]

snRNA processing

snRNA 3'-end processing [inference]

U2 snRNA 3'-end processing

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

RNA 3'-end processing [inference]

snRNA 3'-end processing [inference]

U2 snRNA 3'-end processing

ncRNA processing [inference]

snRNA processing

snRNA 3'-end processing [inference]

U2 snRNA 3'-end processing

ncRNA metabolic process [inference]

snRNA metabolic process [inference]

snRNA processing

snRNA 3'-end processing [inference]

U2 snRNA 3'-end processing

ncRNA processing [inference]

snRNA processing

snRNA 3'-end processing [inference]

U2 snRNA 3'-end processing

reproductive process [inference]

embryo implantation

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of DNA-templated transcription [inference]

regulation of DNA-templated transcription elongation [inference]

regulation of transcription elongation by RNA polymerase II

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of DNA-templated transcription elongation [inference]

regulation of transcription elongation by RNA polymerase II

regulation of cellular metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of RNA metabolic process [inference]

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of DNA-templated transcription elongation [inference]

regulation of transcription elongation by RNA polymerase II

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of DNA-templated transcription [inference]

regulation of DNA-templated transcription elongation [inference]

regulation of transcription elongation by RNA polymerase II

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of DNA-templated transcription elongation [inference]

regulation of transcription elongation by RNA polymerase II

regulation of nitrogen compound metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of RNA metabolic process [inference]

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of DNA-templated transcription elongation [inference]

regulation of transcription elongation by RNA polymerase II

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of DNA-templated transcription [inference]

regulation of DNA-templated transcription elongation [inference]

regulation of transcription elongation by RNA polymerase II

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of DNA-templated transcription elongation [inference]

regulation of transcription elongation by RNA polymerase II

regulation of RNA metabolic process [inference]

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of DNA-templated transcription elongation [inference]

regulation of transcription elongation by RNA polymerase II

regulation of primary metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of RNA metabolic process [inference]

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of DNA-templated transcription elongation [inference]

regulation of transcription elongation by RNA polymerase II

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

regulation of cellular process [inference]

regulation of cellular metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of RNA metabolic process [inference]

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of DNA-templated transcription elongation [inference]

regulation of transcription elongation by RNA polymerase II

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of DNA-templated transcription [inference]

regulation of DNA-templated transcription elongation [inference]

regulation of transcription elongation by RNA polymerase II

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of DNA-templated transcription elongation [inference]

regulation of transcription elongation by RNA polymerase II

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

negative regulation of apoptotic process

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

negative regulation of cellular process [inference]

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
nucleus	NAS	32647223
nucleus	IDA	39032490
nucleoplasm	TAS
membrane	HDA	19946888
nuclear membrane	IEA

GO Hierarchy

cellular component

protein-containing complex [inference]

nuclear protein-containing complex [inference]

integrator complex

cellular anatomical entity [inference]

nucleoplasm

membrane

organelle membrane [inference]

nuclear membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

Displaying 1 entry
GO Term	Evidence Code	PMID
protein binding	IPI	28514442 33961781

GO Hierarchy

molecular function

binding [inference]

protein binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Integrator complex subunit

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
P: Inorganic ion transport and metabolism

Displaying 1 entry
Gene Ontology
U2 snRNA 3'-end processing

Displaying **all 3** entries
InterPro
Armadillo-type fold
Integrator complex subunit 1, RPB2-binding domain
Integrator complex subunit 1

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0070346	neurodevelopmental disorder with cataracts, poor growth, and dysmorphic facies	Alliance of Genome Resources

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

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Guidelines

Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements