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phosphoglycerate dehydrogenase

Summary

Gene Symbol

PHGDH

Organism

Homo sapiens (human)

External Links

NCBI Gene

26227

PubChem

26227

Alliance of Genome Resources

HGNC:8923

Annotation

Keyword

3D-structure
Acetylation
Direct protein sequencing
Disease variant
Isopeptide bond
NAD
Oxidoreductase
Phosphoprotein
Reference proteome
Serine biosynthesis
Ubl conjugation

Proteins

Displaying 1 entry
UniProt	Protein Name
O43175	2-oxoglutarate reductase Malate dehydrogenase

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 13 in total

1

2

3

Next ›

Last »
GO Term	Evidence Code	PMID
spinal cord development	IEA
L-serine biosynthetic process	IEA
G1 to G0 transition	IEA
brain development	TAS	8758134
threonine metabolic process	IEA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

amino acid metabolic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

serine family amino acid biosynthetic process [inference]

L-serine biosynthetic process

gamma-aminobutyric acid metabolic process

alpha-amino acid metabolic process [inference]

glutamine family amino acid metabolic process [inference]

glutamine metabolic process

aspartate family amino acid metabolic process [inference]

threonine metabolic process

serine family amino acid metabolic process [inference]

glycine metabolic process

L-serine metabolic process [inference]

L-serine biosynthetic process

serine family amino acid biosynthetic process [inference]

L-serine biosynthetic process

alpha-amino acid biosynthetic process [inference]

serine family amino acid biosynthetic process [inference]

L-serine biosynthetic process

taurine metabolic process

organonitrogen compound biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

serine family amino acid biosynthetic process [inference]

L-serine biosynthetic process

biosynthetic process [inference]

cellular biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

serine family amino acid biosynthetic process [inference]

L-serine biosynthetic process

small molecule biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

serine family amino acid biosynthetic process [inference]

L-serine biosynthetic process

organic substance biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

serine family amino acid biosynthetic process [inference]

L-serine biosynthetic process

organonitrogen compound biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

serine family amino acid biosynthetic process [inference]

L-serine biosynthetic process

cellular metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

serine family amino acid biosynthetic process [inference]

L-serine biosynthetic process

alkanesulfonate metabolic process [inference]

taurine metabolic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

serine family amino acid biosynthetic process [inference]

L-serine biosynthetic process

gamma-aminobutyric acid metabolic process

alpha-amino acid metabolic process [inference]

glutamine family amino acid metabolic process [inference]

glutamine metabolic process

aspartate family amino acid metabolic process [inference]

threonine metabolic process

serine family amino acid metabolic process [inference]

glycine metabolic process

L-serine metabolic process [inference]

L-serine biosynthetic process

serine family amino acid biosynthetic process [inference]

L-serine biosynthetic process

alpha-amino acid biosynthetic process [inference]

serine family amino acid biosynthetic process [inference]

L-serine biosynthetic process

monocarboxylic acid metabolic process [inference]

gamma-aminobutyric acid metabolic process

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

serine family amino acid biosynthetic process [inference]

L-serine biosynthetic process

sulfur compound metabolic process [inference]

alkanesulfonate metabolic process [inference]

taurine metabolic process

cellular biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

serine family amino acid biosynthetic process [inference]

L-serine biosynthetic process

primary metabolic process [inference]

amino acid metabolic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

serine family amino acid biosynthetic process [inference]

L-serine biosynthetic process

gamma-aminobutyric acid metabolic process

alpha-amino acid metabolic process [inference]

glutamine family amino acid metabolic process [inference]

glutamine metabolic process

aspartate family amino acid metabolic process [inference]

threonine metabolic process

serine family amino acid metabolic process [inference]

glycine metabolic process

L-serine metabolic process [inference]

L-serine biosynthetic process

serine family amino acid biosynthetic process [inference]

L-serine biosynthetic process

alpha-amino acid biosynthetic process [inference]

serine family amino acid biosynthetic process [inference]

L-serine biosynthetic process

small molecule metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

serine family amino acid biosynthetic process [inference]

L-serine biosynthetic process

alkanesulfonate metabolic process [inference]

taurine metabolic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

serine family amino acid biosynthetic process [inference]

L-serine biosynthetic process

gamma-aminobutyric acid metabolic process

alpha-amino acid metabolic process [inference]

glutamine family amino acid metabolic process [inference]

glutamine metabolic process

aspartate family amino acid metabolic process [inference]

threonine metabolic process

serine family amino acid metabolic process [inference]

glycine metabolic process

L-serine metabolic process [inference]

L-serine biosynthetic process

serine family amino acid biosynthetic process [inference]

L-serine biosynthetic process

alpha-amino acid biosynthetic process [inference]

serine family amino acid biosynthetic process [inference]

L-serine biosynthetic process

monocarboxylic acid metabolic process [inference]

gamma-aminobutyric acid metabolic process

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

serine family amino acid biosynthetic process [inference]

L-serine biosynthetic process

small molecule biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

serine family amino acid biosynthetic process [inference]

L-serine biosynthetic process

organic substance metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

serine family amino acid biosynthetic process [inference]

L-serine biosynthetic process

alkanesulfonate metabolic process [inference]

taurine metabolic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

serine family amino acid biosynthetic process [inference]

L-serine biosynthetic process

gamma-aminobutyric acid metabolic process

alpha-amino acid metabolic process [inference]

glutamine family amino acid metabolic process [inference]

glutamine metabolic process

aspartate family amino acid metabolic process [inference]

threonine metabolic process

serine family amino acid metabolic process [inference]

glycine metabolic process

L-serine metabolic process [inference]

L-serine biosynthetic process

serine family amino acid biosynthetic process [inference]

L-serine biosynthetic process

alpha-amino acid biosynthetic process [inference]

serine family amino acid biosynthetic process [inference]

L-serine biosynthetic process

monocarboxylic acid metabolic process [inference]

gamma-aminobutyric acid metabolic process

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

serine family amino acid biosynthetic process [inference]

L-serine biosynthetic process

organonitrogen compound metabolic process [inference]

amino acid metabolic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

serine family amino acid biosynthetic process [inference]

L-serine biosynthetic process

gamma-aminobutyric acid metabolic process

alpha-amino acid metabolic process [inference]

glutamine family amino acid metabolic process [inference]

glutamine metabolic process

aspartate family amino acid metabolic process [inference]

threonine metabolic process

serine family amino acid metabolic process [inference]

glycine metabolic process

L-serine metabolic process [inference]

L-serine biosynthetic process

serine family amino acid biosynthetic process [inference]

L-serine biosynthetic process

alpha-amino acid biosynthetic process [inference]

serine family amino acid biosynthetic process [inference]

L-serine biosynthetic process

taurine metabolic process

organonitrogen compound biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

serine family amino acid biosynthetic process [inference]

L-serine biosynthetic process

organic substance biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

serine family amino acid biosynthetic process [inference]

L-serine biosynthetic process

organonitrogen compound biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

serine family amino acid biosynthetic process [inference]

L-serine biosynthetic process

cellular process [inference]

cell cycle process [inference]

G1 to G0 transition

cellular metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

serine family amino acid biosynthetic process [inference]

L-serine biosynthetic process

alkanesulfonate metabolic process [inference]

taurine metabolic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

serine family amino acid biosynthetic process [inference]

L-serine biosynthetic process

gamma-aminobutyric acid metabolic process

alpha-amino acid metabolic process [inference]

glutamine family amino acid metabolic process [inference]

glutamine metabolic process

aspartate family amino acid metabolic process [inference]

threonine metabolic process

serine family amino acid metabolic process [inference]

glycine metabolic process

L-serine metabolic process [inference]

L-serine biosynthetic process

serine family amino acid biosynthetic process [inference]

L-serine biosynthetic process

alpha-amino acid biosynthetic process [inference]

serine family amino acid biosynthetic process [inference]

L-serine biosynthetic process

monocarboxylic acid metabolic process [inference]

gamma-aminobutyric acid metabolic process

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

serine family amino acid biosynthetic process [inference]

L-serine biosynthetic process

sulfur compound metabolic process [inference]

alkanesulfonate metabolic process [inference]

taurine metabolic process

cellular biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

serine family amino acid biosynthetic process [inference]

L-serine biosynthetic process

cellular developmental process [inference]

cell development [inference]

glial cell development

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cell projection organization [inference]

plasma membrane bounded cell projection organization [inference]

neuron projection development

developmental process [inference]

anatomical structure development [inference]

tissue development [inference]

epithelium development [inference]

neural tube development

spinal cord development

tube development [inference]

neural tube development

cell development [inference]

glial cell development

animal organ development [inference]

brain development

cellular developmental process [inference]

cell development [inference]

glial cell development

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression

regulation of cellular metabolic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression

regulation of cellular process [inference]

regulation of cellular metabolic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression

Displaying **all 2** entries
GO Term	Evidence Code	PMID
cytosol	TAS
extracellular exosome	HDA	19056867 19199708 20458337 23533145

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytosol

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying **all 5** entries
GO Term	Evidence Code	PMID
protein binding	IPI	25036637 33961781 35271311
NAD binding	IEA
phosphoglycerate dehydrogenase activity	IBA
L-malate dehydrogenase activity	IEA
electron transfer activity	TAS	8758134

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

electron transfer activity

oxidoreductase activity, acting on CH-OH group of donors [inference]

malate dehydrogenase activity [inference]

L-malate dehydrogenase activity

oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [inference]

binding [inference]

protein binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

NAD binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

NAD binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

D-3-phosphoglycerate dehydrogenase

Functional Category

C: Energy production and conversion
E: Amino acid transport and metabolism
T: Signal transduction mechanisms

Displaying **all 3** entries
Gene Ontology
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
oxidoreductase activity
phosphoglycerate dehydrogenase activity

Displaying **all 5** entries
InterPro
D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain conserved site 1
D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain conserved site
D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain
D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain
NAD(P)-binding domain superfamily

Disease

Disease Ontology

Displaying **all 3** entries
DO ID	Disease Name	Source
DOID:0050722	PHGDH deficiency	Alliance of Genome Resources
DOID:0080076	Neu-Laxova syndrome 1	Alliance of Genome Resources
DOID:9252	amino acid metabolic disorder	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 85 in total

1

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Drosophila melanogaster	34554		FB:FBgn0032350
Rattus norvegicus	58835		RGD:61987	RATNO24260
Caenorhabditis elegans	175012		WB:WBGene00007836
Mus musculus	236539		MGI:1355330	MOUSE37749
Danio rerio	321928		ZFIN:ZDB-GENE-030131-647	DANRE43998
Bos taurus	505103			BOVIN26136
Xenopus tropicalis	548683		Xenbase:XB-GENE-5854283
Canis lupus familiaris	607890			CANLF05318
Macaca mulatta	713480			MACMU21683
Pan troglodytes	739534	9598_0:000210		PANTR21869

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GlyCosmos Portal v4.1.0

Last updated: December 9, 2024