GlyCosmos Portal

GlyTouCan

Glycan Structure Repository

GlyComb

Glycoconjugate Repository

GlycoPOST

Glycomics MS raw data Repository

UniCarb-DR

Glycomics MS Repository for glycan annotations from GlycoWorkbench

LM-GlycoRepo

Repository for lectin-assisted multimodality data

All Resources

Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms

Other Information

Release Statistics Download

Tools

Glycan Converters

LM-GlycomeAtlas

Search Tools

Cross Search Glycan Search Publication Search Programmatic Access

phosphoglycerate dehydrogenase

Summary

Gene Symbol

PHGDH

Organism

Homo sapiens (human)

External Links

NCBI Gene

26227

PubChem

26227

Alliance of Genome Resources

HGNC:8923

Annotation

Keyword

3D-structure
Acetylation
Direct protein sequencing
Disease variant
Isopeptide bond
NAD
Oxidoreductase
Phosphoprotein
Reference proteome
Serine biosynthesis
Ubl conjugation

Proteins

Displaying 1 entry
UniProt	Protein Name
O43175	2-oxoglutarate reductase Malate dehydrogenase

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **11 - 13** of 13 in total

« First

‹ Prev

1

2

3
GO Term	Evidence Code	PMID
gamma-aminobutyric acid metabolic process	IEA
glutamine metabolic process	IEA
taurine metabolic process	IEA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

amino acid metabolic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

serine family amino acid biosynthetic process [inference]

L-serine biosynthetic process

gamma-aminobutyric acid metabolic process

alpha-amino acid metabolic process [inference]

glutamine family amino acid metabolic process [inference]

glutamine metabolic process

aspartate family amino acid metabolic process [inference]

threonine metabolic process

serine family amino acid metabolic process [inference]

glycine metabolic process

L-serine metabolic process [inference]

L-serine biosynthetic process

serine family amino acid biosynthetic process [inference]

L-serine biosynthetic process

alpha-amino acid biosynthetic process [inference]

serine family amino acid biosynthetic process [inference]

L-serine biosynthetic process

taurine metabolic process

organonitrogen compound biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

serine family amino acid biosynthetic process [inference]

L-serine biosynthetic process

biosynthetic process [inference]

cellular biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

serine family amino acid biosynthetic process [inference]

L-serine biosynthetic process

small molecule biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

serine family amino acid biosynthetic process [inference]

L-serine biosynthetic process

organic substance biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

serine family amino acid biosynthetic process [inference]

L-serine biosynthetic process

organonitrogen compound biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

serine family amino acid biosynthetic process [inference]

L-serine biosynthetic process

cellular metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

serine family amino acid biosynthetic process [inference]

L-serine biosynthetic process

alkanesulfonate metabolic process [inference]

taurine metabolic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

serine family amino acid biosynthetic process [inference]

L-serine biosynthetic process

gamma-aminobutyric acid metabolic process

alpha-amino acid metabolic process [inference]

glutamine family amino acid metabolic process [inference]

glutamine metabolic process

aspartate family amino acid metabolic process [inference]

threonine metabolic process

serine family amino acid metabolic process [inference]

glycine metabolic process

L-serine metabolic process [inference]

L-serine biosynthetic process

serine family amino acid biosynthetic process [inference]

L-serine biosynthetic process

alpha-amino acid biosynthetic process [inference]

serine family amino acid biosynthetic process [inference]

L-serine biosynthetic process

monocarboxylic acid metabolic process [inference]

gamma-aminobutyric acid metabolic process

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

serine family amino acid biosynthetic process [inference]

L-serine biosynthetic process

sulfur compound metabolic process [inference]

alkanesulfonate metabolic process [inference]

taurine metabolic process

cellular biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

serine family amino acid biosynthetic process [inference]

L-serine biosynthetic process

primary metabolic process [inference]

amino acid metabolic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

serine family amino acid biosynthetic process [inference]

L-serine biosynthetic process

gamma-aminobutyric acid metabolic process

alpha-amino acid metabolic process [inference]

glutamine family amino acid metabolic process [inference]

glutamine metabolic process

aspartate family amino acid metabolic process [inference]

threonine metabolic process

serine family amino acid metabolic process [inference]

glycine metabolic process

L-serine metabolic process [inference]

L-serine biosynthetic process

serine family amino acid biosynthetic process [inference]

L-serine biosynthetic process

alpha-amino acid biosynthetic process [inference]

serine family amino acid biosynthetic process [inference]

L-serine biosynthetic process

small molecule metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

serine family amino acid biosynthetic process [inference]

L-serine biosynthetic process

alkanesulfonate metabolic process [inference]

taurine metabolic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

serine family amino acid biosynthetic process [inference]

L-serine biosynthetic process

gamma-aminobutyric acid metabolic process

alpha-amino acid metabolic process [inference]

glutamine family amino acid metabolic process [inference]

glutamine metabolic process

aspartate family amino acid metabolic process [inference]

threonine metabolic process

serine family amino acid metabolic process [inference]

glycine metabolic process

L-serine metabolic process [inference]

L-serine biosynthetic process

serine family amino acid biosynthetic process [inference]

L-serine biosynthetic process

alpha-amino acid biosynthetic process [inference]

serine family amino acid biosynthetic process [inference]

L-serine biosynthetic process

monocarboxylic acid metabolic process [inference]

gamma-aminobutyric acid metabolic process

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

serine family amino acid biosynthetic process [inference]

L-serine biosynthetic process

small molecule biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

serine family amino acid biosynthetic process [inference]

L-serine biosynthetic process

organic substance metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

serine family amino acid biosynthetic process [inference]

L-serine biosynthetic process

alkanesulfonate metabolic process [inference]

taurine metabolic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

serine family amino acid biosynthetic process [inference]

L-serine biosynthetic process

gamma-aminobutyric acid metabolic process

alpha-amino acid metabolic process [inference]

glutamine family amino acid metabolic process [inference]

glutamine metabolic process

aspartate family amino acid metabolic process [inference]

threonine metabolic process

serine family amino acid metabolic process [inference]

glycine metabolic process

L-serine metabolic process [inference]

L-serine biosynthetic process

serine family amino acid biosynthetic process [inference]

L-serine biosynthetic process

alpha-amino acid biosynthetic process [inference]

serine family amino acid biosynthetic process [inference]

L-serine biosynthetic process

monocarboxylic acid metabolic process [inference]

gamma-aminobutyric acid metabolic process

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

serine family amino acid biosynthetic process [inference]

L-serine biosynthetic process

organonitrogen compound metabolic process [inference]

amino acid metabolic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

serine family amino acid biosynthetic process [inference]

L-serine biosynthetic process

gamma-aminobutyric acid metabolic process

alpha-amino acid metabolic process [inference]

glutamine family amino acid metabolic process [inference]

glutamine metabolic process

aspartate family amino acid metabolic process [inference]

threonine metabolic process

serine family amino acid metabolic process [inference]

glycine metabolic process

L-serine metabolic process [inference]

L-serine biosynthetic process

serine family amino acid biosynthetic process [inference]

L-serine biosynthetic process

alpha-amino acid biosynthetic process [inference]

serine family amino acid biosynthetic process [inference]

L-serine biosynthetic process

taurine metabolic process

organonitrogen compound biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

serine family amino acid biosynthetic process [inference]

L-serine biosynthetic process

organic substance biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

serine family amino acid biosynthetic process [inference]

L-serine biosynthetic process

organonitrogen compound biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

serine family amino acid biosynthetic process [inference]

L-serine biosynthetic process

cellular process [inference]

cell cycle process [inference]

G1 to G0 transition

cellular metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

serine family amino acid biosynthetic process [inference]

L-serine biosynthetic process

alkanesulfonate metabolic process [inference]

taurine metabolic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

serine family amino acid biosynthetic process [inference]

L-serine biosynthetic process

gamma-aminobutyric acid metabolic process

alpha-amino acid metabolic process [inference]

glutamine family amino acid metabolic process [inference]

glutamine metabolic process

aspartate family amino acid metabolic process [inference]

threonine metabolic process

serine family amino acid metabolic process [inference]

glycine metabolic process

L-serine metabolic process [inference]

L-serine biosynthetic process

serine family amino acid biosynthetic process [inference]

L-serine biosynthetic process

alpha-amino acid biosynthetic process [inference]

serine family amino acid biosynthetic process [inference]

L-serine biosynthetic process

monocarboxylic acid metabolic process [inference]

gamma-aminobutyric acid metabolic process

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

serine family amino acid biosynthetic process [inference]

L-serine biosynthetic process

sulfur compound metabolic process [inference]

alkanesulfonate metabolic process [inference]

taurine metabolic process

cellular biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

serine family amino acid biosynthetic process [inference]

L-serine biosynthetic process

cellular developmental process [inference]

cell development [inference]

glial cell development

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cell projection organization [inference]

plasma membrane bounded cell projection organization [inference]

neuron projection development

developmental process [inference]

anatomical structure development [inference]

tissue development [inference]

epithelium development [inference]

neural tube development

spinal cord development

tube development [inference]

neural tube development

cell development [inference]

glial cell development

animal organ development [inference]

brain development

cellular developmental process [inference]

cell development [inference]

glial cell development

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression

regulation of cellular metabolic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression

regulation of cellular process [inference]

regulation of cellular metabolic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression

Displaying **all 2** entries
GO Term	Evidence Code	PMID
cytosol	TAS
extracellular exosome	HDA	19056867 19199708 20458337 23533145

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytosol

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying **all 5** entries
GO Term	Evidence Code	PMID
protein binding	IPI	25036637 33961781 35271311
NAD binding	IEA
phosphoglycerate dehydrogenase activity	IBA
L-malate dehydrogenase activity	IEA
electron transfer activity	TAS	8758134

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

electron transfer activity

oxidoreductase activity, acting on CH-OH group of donors [inference]

malate dehydrogenase activity [inference]

L-malate dehydrogenase activity

oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [inference]

binding [inference]

protein binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

NAD binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

NAD binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

D-3-phosphoglycerate dehydrogenase

Functional Category

C: Energy production and conversion
E: Amino acid transport and metabolism
T: Signal transduction mechanisms

Displaying **all 3** entries
Gene Ontology
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
oxidoreductase activity
phosphoglycerate dehydrogenase activity

Displaying **all 5** entries
InterPro
D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain conserved site 1
D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain conserved site
D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain
D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain
NAD(P)-binding domain superfamily

Disease

Disease Ontology

Displaying **all 3** entries
DO ID	Disease Name	Source
DOID:0050722	PHGDH deficiency	Alliance of Genome Resources
DOID:0080076	Neu-Laxova syndrome 1	Alliance of Genome Resources
DOID:9252	amino acid metabolic disorder	Alliance of Genome Resources

Ortholog

Displaying entries **71 - 80** of 85 in total

« First

‹ Prev

…

4

5

6

7

8

9

Next ›

Last »
Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Echeneis naucrates	115062021			ECHNA12878
Salmo trutta	115156035			SALTR09260
Salmo trutta	115160744			SALTR15418
Salarias fasciatus	115403019			SALFA51944
Taeniopygia guttata	115496299			TAEGU29704
Sparus aurata	115588688			SPAAU29549
Strigops habroptila	115612304			STRHB11960
Corvus moneduloides	116448237			CORMO26662
Balaenoptera musculus	118901349			BALMU23689
Canis lupus familiaris	119863969			CANLF05318

About Release Notes Help Feedback

International Collaboration

GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

Logo License Policies Site Map

Contact: support@glycosmos.org

GlyCosmos Portal v4.1.0

Last updated: December 9, 2024