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heat shock protein family B (small) member 8

Summary

Gene Symbol

HSPB8

Organism

Homo sapiens (human)

External Links

NCBI Gene

26353

PubChem

26353

Alliance of Genome Resources

HGNC:30171

Annotation

Keyword

Chaperone
Charcot-Marie-Tooth disease
Cytoplasm
Disease variant
Methylation
Neurodegeneration
Nucleus
Phosphoprotein
Reference proteome
Stress response

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9UJY1	Alpha-crystallin C chain E2-induced gene 1 protein Heat shock protein family B member 8 Protein kinase H11 Small stress protein-like protein HSP22

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 2** entries
GO Term	Evidence Code	PMID
cellular response to unfolded protein	IBA IMP	18006506
positive regulation of aggrephagy	IMP	18006506

GO Hierarchy

biological process

cellular process [inference]

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to topologically incorrect protein [inference]

cellular response to unfolded protein

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to topologically incorrect protein [inference]

cellular response to unfolded protein

response to stimulus [inference]

response to stress [inference]

cellular response to stress [inference]

cellular response to topologically incorrect protein [inference]

cellular response to unfolded protein

response to topologically incorrect protein [inference]

response to unfolded protein [inference]

cellular response to unfolded protein

cellular response to topologically incorrect protein [inference]

cellular response to unfolded protein

response to chemical [inference]

response to organic substance [inference]

response to topologically incorrect protein [inference]

response to unfolded protein [inference]

cellular response to unfolded protein

cellular response to topologically incorrect protein [inference]

cellular response to unfolded protein

cellular response to organic substance [inference]

cellular response to topologically incorrect protein [inference]

cellular response to unfolded protein

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to topologically incorrect protein [inference]

cellular response to unfolded protein

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to topologically incorrect protein [inference]

cellular response to unfolded protein

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to topologically incorrect protein [inference]

cellular response to unfolded protein

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

positive regulation of metabolic process [inference]

positive regulation of catabolic process [inference]

positive regulation of cellular catabolic process [inference]

positive regulation of autophagy [inference]

positive regulation of macroautophagy [inference]

positive regulation of aggrephagy

positive regulation of cellular metabolic process [inference]

positive regulation of cellular catabolic process [inference]

positive regulation of autophagy [inference]

positive regulation of macroautophagy [inference]

positive regulation of aggrephagy

regulation of catabolic process [inference]

positive regulation of catabolic process [inference]

positive regulation of cellular catabolic process [inference]

positive regulation of autophagy [inference]

positive regulation of macroautophagy [inference]

positive regulation of aggrephagy

regulation of cellular catabolic process [inference]

regulation of autophagy [inference]

positive regulation of autophagy [inference]

positive regulation of macroautophagy [inference]

positive regulation of aggrephagy

regulation of macroautophagy [inference]

positive regulation of macroautophagy [inference]

positive regulation of aggrephagy

regulation of aggrephagy [inference]

positive regulation of aggrephagy

positive regulation of cellular catabolic process [inference]

positive regulation of autophagy [inference]

positive regulation of macroautophagy [inference]

positive regulation of aggrephagy

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular catabolic process [inference]

positive regulation of autophagy [inference]

positive regulation of macroautophagy [inference]

positive regulation of aggrephagy

regulation of cellular catabolic process [inference]

regulation of autophagy [inference]

positive regulation of autophagy [inference]

positive regulation of macroautophagy [inference]

positive regulation of aggrephagy

regulation of macroautophagy [inference]

positive regulation of macroautophagy [inference]

positive regulation of aggrephagy

regulation of aggrephagy [inference]

positive regulation of aggrephagy

positive regulation of cellular catabolic process [inference]

positive regulation of autophagy [inference]

positive regulation of macroautophagy [inference]

positive regulation of aggrephagy

positive regulation of biological process [inference]

positive regulation of metabolic process [inference]

positive regulation of catabolic process [inference]

positive regulation of cellular catabolic process [inference]

positive regulation of autophagy [inference]

positive regulation of macroautophagy [inference]

positive regulation of aggrephagy

positive regulation of cellular metabolic process [inference]

positive regulation of cellular catabolic process [inference]

positive regulation of autophagy [inference]

positive regulation of macroautophagy [inference]

positive regulation of aggrephagy

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular catabolic process [inference]

positive regulation of autophagy [inference]

positive regulation of macroautophagy [inference]

positive regulation of aggrephagy

regulation of cellular process [inference]

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular catabolic process [inference]

positive regulation of autophagy [inference]

positive regulation of macroautophagy [inference]

positive regulation of aggrephagy

regulation of cellular catabolic process [inference]

regulation of autophagy [inference]

positive regulation of autophagy [inference]

positive regulation of macroautophagy [inference]

positive regulation of aggrephagy

regulation of macroautophagy [inference]

positive regulation of macroautophagy [inference]

positive regulation of aggrephagy

regulation of aggrephagy [inference]

positive regulation of aggrephagy

positive regulation of cellular catabolic process [inference]

positive regulation of autophagy [inference]

positive regulation of macroautophagy [inference]

positive regulation of aggrephagy

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular catabolic process [inference]

positive regulation of autophagy [inference]

positive regulation of macroautophagy [inference]

positive regulation of aggrephagy

Displaying **all 5** entries
GO Term	Evidence Code	PMID
nucleoplasm	IDA TAS
protein folding chaperone complex	IBA IDA	18006506
nucleus	IBA IDA	19464326
cytosol	IDA
cytoplasm	IBA IDA	19464326 28144995

GO Hierarchy

cellular component

protein-containing complex [inference]

intracellular protein-containing complex [inference]

protein folding chaperone complex

cellular anatomical entity [inference]

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

Displaying **all 4** entries
GO Term	Evidence Code	PMID
protein binding	IPI	14594798 16189514 18006506 21516116 22366786 23414517 25036637 25416956 26496610 28144995 28514442 31273097 32296183 32707033 33961781
identical protein binding	IPI	14594798
protein kinase activity	IDA	14985082
protein homodimerization activity	IPI	18006506

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring phosphorus-containing groups [inference]

kinase activity [inference]

protein kinase activity

phosphotransferase activity, alcohol group as acceptor [inference]

protein kinase activity

catalytic activity, acting on a protein [inference]

protein kinase activity

binding [inference]

protein binding

identical protein binding

protein homodimerization activity

protein dimerization activity [inference]

protein homodimerization activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Heat shock protein beta-1

Functional Category

O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
protein refolding
unfolded protein binding

Displaying **all 3** entries
InterPro
Alpha crystallin/Hsp20 domain
Alpha crystallin/Small heat shock protein, animal type
HSP20-like chaperone

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:0110174	Charcot-Marie-Tooth disease axonal type 2L	Alliance of Genome Resources
DOID:0111206	autosomal dominant distal hereditary motor neuronopathy 2	Alliance of Genome Resources

Ortholog

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Species	Gene ID	OrthoDB	Orthologous MAtrix
Pongo abelii	100174469	9601_0:003624	PONAB05774
Pongo abelii	100189671		PONAB05774
Taeniopygia guttata	100223755		TAEGU05681
Callithrix jacchus	100409042		CALJA45536
Ailuropoda melanoleuca	100463910		AILME12332
Anolis carolinensis	100559087		ANOCA14942
Nomascus leucogenys	100603286		NOMLE00760
Loxodonta africana	100676830		LOXAF04730
Cavia porcellus	100734199		CAVPO02723
Cricetulus griseus	100754642		CRIGR01304