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ATP binding cassette subfamily G member 2 (Junior blood group)

Summary

Gene Symbol

Abcg2

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

26357

PubChem

26357

Alliance of Genome Resources

MGI:1347061

Annotation

Keyword

ATP-binding
Cell membrane
Disulfide bond
Glycoprotein
Lipid transport
Mitochondrion
Phosphoprotein
Proteomics identification
Reference proteome
Translocase
Transmembrane helix
Transport

Proteins

Displaying **all 2** entries
UniProt	Protein Name
A0A0R4J0B6	ATP-binding cassette sub-family G member 2 Urate exporter
Q7TMS5	ATP-binding cassette sub-family G member 2 Breast cancer resistance protein 1 homolog Urate exporter

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 21 in total

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GO Term	Evidence Code	PMID
lipid transport	IEA
organic anion transport	ISO
urate transport	ISO
urate transport	IEA
biotin transport	IMP	17145775

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

purine-containing compound metabolic process [inference]

urate metabolic process

organonitrogen compound metabolic process [inference]

purine-containing compound metabolic process [inference]

urate metabolic process

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

purine-containing compound metabolic process [inference]

urate metabolic process

cellular nitrogen compound metabolic process [inference]

purine-containing compound metabolic process [inference]

urate metabolic process

heterocycle metabolic process [inference]

purine-containing compound metabolic process [inference]

urate metabolic process

small molecule metabolic process [inference]

urate metabolic process

organic substance metabolic process [inference]

organic cyclic compound metabolic process [inference]

purine-containing compound metabolic process [inference]

urate metabolic process

organonitrogen compound metabolic process [inference]

purine-containing compound metabolic process [inference]

urate metabolic process

cellular process [inference]

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

purine-containing compound metabolic process [inference]

urate metabolic process

cellular nitrogen compound metabolic process [inference]

purine-containing compound metabolic process [inference]

urate metabolic process

heterocycle metabolic process [inference]

purine-containing compound metabolic process [inference]

urate metabolic process

transmembrane transport

xenobiotic export from cell [inference]

xenobiotic detoxification by transmembrane export across the plasma membrane

export across plasma membrane

xenobiotic detoxification by transmembrane export across the plasma membrane

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

protein-containing complex assembly

protein-containing complex organization [inference]

protein-containing complex assembly

export from cell [inference]

xenobiotic export from cell [inference]

xenobiotic detoxification by transmembrane export across the plasma membrane

export across plasma membrane

xenobiotic detoxification by transmembrane export across the plasma membrane

reproductive process [inference]

multicellular organismal reproductive process [inference]

embryonic process involved in female pregnancy

multicellular organismal process [inference]

system process [inference]

circulatory system process [inference]

vascular process in circulatory system [inference]

vascular transport [inference]

transport across blood-brain barrier [inference]

xenobiotic transport across blood-brain barrier

renal system process [inference]

renal tubular secretion [inference]

renal urate salt excretion

excretion [inference]

renal tubular secretion [inference]

renal urate salt excretion

localization [inference]

establishment of localization [inference]

transport [inference]

vascular transport [inference]

transport across blood-brain barrier [inference]

xenobiotic transport across blood-brain barrier

xenobiotic transport

xenobiotic export from cell [inference]

xenobiotic detoxification by transmembrane export across the plasma membrane

xenobiotic transport across blood-brain barrier

vitamin transport [inference]

transmembrane transport

xenobiotic export from cell [inference]

xenobiotic detoxification by transmembrane export across the plasma membrane

export across plasma membrane

xenobiotic detoxification by transmembrane export across the plasma membrane

transepithelial transport

organic substance transport [inference]

lipid transport

organic anion transport

carboxylic acid transport [inference]

monocarboxylic acid transport [inference]

biotin transport

organic acid transport [inference]

carboxylic acid transport [inference]

monocarboxylic acid transport [inference]

biotin transport

nitrogen compound transport [inference]

amide transport [inference]

biotin transport

sulfur compound transport [inference]

biotin transport

export from cell [inference]

xenobiotic export from cell [inference]

xenobiotic detoxification by transmembrane export across the plasma membrane

export across plasma membrane

xenobiotic detoxification by transmembrane export across the plasma membrane

biological regulation [inference]

regulation of biological process [inference]

regulation of localization [inference]

regulation of transport [inference]

negative regulation of transport [inference]

negative regulation of intestinal absorption

regulation of intestinal absorption [inference]

negative regulation of intestinal absorption

negative regulation of biological process [inference]

negative regulation of transport [inference]

negative regulation of intestinal absorption

negative regulation of multicellular organismal process [inference]

negative regulation of digestive system process [inference]

negative regulation of intestinal absorption

regulation of multicellular organismal process [inference]

regulation of system process [inference]

regulation of digestive system process [inference]

negative regulation of digestive system process [inference]

negative regulation of intestinal absorption

regulation of intestinal absorption [inference]

negative regulation of intestinal absorption

negative regulation of multicellular organismal process [inference]

negative regulation of digestive system process [inference]

negative regulation of intestinal absorption

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	PMID
nucleoplasm	ISO
plasma membrane	ISO
plasma membrane	TAS
plasma membrane	IBA
apical plasma membrane	ISO

GO Hierarchy

cellular component

cellular anatomical entity [inference]

nucleoplasm

membrane [inference]

plasma membrane

organelle membrane [inference]

mitochondrial membrane

plasma membrane region [inference]

apical plasma membrane

cell projection membrane [inference]

brush border membrane

membrane microdomain [inference]

membrane raft

side of membrane [inference]

external side of plasma membrane [inference]

external side of apical plasma membrane

Displaying entries **1 - 5** of 21 in total

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GO Term	Evidence Code	PMID
ATP binding	IEA
cytoskeletal protein binding	ISO
organic anion transmembrane transporter activity	ISO
ABC-type xenobiotic transporter activity	IEA
urate transmembrane transporter activity	ISS

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on acid anhydrides [inference]

hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [inference]

pyrophosphatase activity [inference]

ribonucleoside triphosphate phosphatase activity [inference]

ATP hydrolysis activity

transporter activity [inference]

transmembrane transporter activity [inference]

organic acid transmembrane transporter activity [inference]

carboxylic acid transmembrane transporter activity [inference]

monocarboxylic acid transmembrane transporter activity [inference]

biotin transmembrane transporter activity

organic anion transmembrane transporter activity

riboflavin transmembrane transporter activity

carboxylic acid transmembrane transporter activity [inference]

monocarboxylic acid transmembrane transporter activity [inference]

biotin transmembrane transporter activity

efflux transmembrane transporter activity

active transmembrane transporter activity [inference]

primary active transmembrane transporter activity [inference]

ATPase-coupled transmembrane transporter activity

ABC-type transporter activity [inference]

ABC-type xenobiotic transporter activity

amide transmembrane transporter activity

biotin transmembrane transporter activity

xenobiotic transmembrane transporter activity

ABC-type xenobiotic transporter activity

vitamin transmembrane transporter activity [inference]

sulfur compound transmembrane transporter activity [inference]

biotin transmembrane transporter activity

salt transmembrane transporter activity [inference]

binding [inference]

protein binding [inference]

cytoskeletal protein binding

identical protein binding

protein homodimerization activity

protein dimerization activity [inference]

protein homodimerization activity

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ATP-dependent activity [inference]

ATPase-coupled transmembrane transporter activity

ABC-type transporter activity [inference]

ABC-type xenobiotic transporter activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

ATP-binding cassette sub-family G member

Functional Category

C: Energy production and conversion
Q: Secondary metabolites biosynthesis, transport and catabolism
T: Signal transduction mechanisms

Displaying **all 3** entries
Gene Ontology
ABC-type transporter activity
ATP binding
nucleotide binding

Displaying **all 5** entries
InterPro
AAA+ ATPase domain
ABC transporter family G domain
ABC transporter-like, ATP-binding domain
ABC-2 type transporter, transmembrane domain
P-loop containing nucleoside triphosphate hydrolase

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:13270	erythropoietic protoporphyria	Alliance of Genome Resources
DOID:1920	hyperuricemia	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 65 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	9429	Xenbase:XB-GENE-991895	HUMAN76514
Caenorhabditis elegans	9619	WB:WBGene00017179
Xenopus tropicalis	26357	Xenbase:XB-GENE-991895
Danio rerio	31271	ZFIN:ZDB-GENE-050517-38
Xenopus tropicalis	39836	Xenbase:XB-GENE-991895
Caenorhabditis elegans	64137	WB:WBGene00017179
Rattus norvegicus	312382	Xenbase:XB-GENE-991895	RATNO29675
Sus scrofa	397073		PIGXX34445
Pan troglodytes	471251		PANTR34094
Canis lupus familiaris	478472		CANLF13058