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MIRAGE
FTO alpha-ketoglutarate dependent dioxygenase

Summary
Gene Symbol
  • Fto
Organism
Mus musculus (house mouse)
NCBI Gene
26383
PubChem
26383
Alliance of Genome Resources
Annotation
Keyword
  • Acetylation
  • Alternative splicing
  • Cytoplasm
  • Dioxygenase
  • Iron
  • Metal-binding
  • Nucleus
  • Reference proteome
Proteins
Displaying 1 entry
UniProt Protein Name
Q8BGW1
  • Fat mass and obesity-associated protein
  • Protein fatso
  • U6 small nuclear RNA (2'-O-methyladenosine-N(6)-)-demethylase FTO
  • U6 small nuclear RNA N(6)-methyladenosine-demethylase FTO
  • mRNA (2'-O-methyladenosine-N(6)-)-demethylase FTO
  • mRNA N(6)-methyladenosine demethylase FTO
  • tRNA N1-methyl adenine demethylase FTO
Annotation information from UniProt.
Gene Ontology (GO)
Displaying entries 1 - 5 of 22 in total
GO Term Evidence Code PMID
osteoblast differentiation
temperature homeostasis
DNA dealkylation involved in DNA repair
DNA dealkylation involved in DNA repair
regulation of lipid storage
GO Hierarchy
Displaying entries 1 - 5 of 14 in total
GO Term Evidence Code PMID
ferrous iron binding
ferrous iron binding
ferrous iron binding
2-oxoglutarate-dependent dioxygenase activity
oxidative RNA demethylase activity
GO Hierarchy
Gene Ontology information from NCBI Gene and UniProt.
OrthoDB (Group)
Group level
Eukaryota
Group Name
Alpha-ketoglutarate-dependent dioxygenase FTO
Functional Category
  • E: Amino acid transport and metabolism
  • O: Posttranslational modification, protein turnover, chaperones
  • T: Signal transduction mechanisms
Displaying entries 1 - 10 of 11 in total
Gene Ontology
DNA dealkylation involved in DNA repair
RNA repair
dioxygenase activity
ferrous iron binding
mRNA N6-methyladenosine dioxygenase activity
metal ion binding
oxidative RNA demethylase activity
oxidative single-stranded DNA demethylation
oxidative single-stranded RNA demethylation
oxidoreductase activity
Displaying all 5 entries
InterPro
Alpha-ketoglutarate-dependent dioxygenase AlkB-like superfamily
Alpha-ketoglutarate-dependent dioxygenase FTO, C-terminal
Alpha-ketoglutarate-dependent dioxygenase FTO, catalytic domain
Alpha-ketoglutarate-dependent dioxygenase FTO
FTO, C-terminal domain superfamily
Ortholog
Displaying entries 1 - 10 of 77 in total
Species Gene ID Alliance of Genome Resources Orthologous MAtrix
26383 Xenbase:XB-GENE-972564
79068 Xenbase:XB-GENE-972564 HUMAN28269
291905 RATNO14421
454090 PANTR12363
478125 CANLF06845
553363 DANRE41082
618622 BOVIN10439
703724 MACMU26210
100019431 MONDO07157
100060565 HORSE30483
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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: April 7, 2025