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homer scaffolding protein 1

Summary

Gene Symbol

Homer1

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

26556

PubChem

26556

Alliance of Genome Resources

MGI:1347345

Annotation

Keyword

Acetylation
Alternative splicing
Cell projection
Coiled coil
Cytoplasm
Phosphoprotein
Proteomics identification
Reference proteome
Synapse

Proteins

Displaying **all 3** entries
UniProt	Protein Name
Q9Z2Y3	VASP/Ena-related gene up-regulated during seizure and LTP 1
Q3UVL6
Q5D052

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 26 in total

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GO Term	Evidence Code	PMID
skeletal muscle contraction	IMP	18268005
G protein-coupled glutamate receptor signaling pathway	ISO
G protein-coupled glutamate receptor signaling pathway	TAS	9808458
G protein-coupled glutamate receptor signaling pathway	IBA
circadian rhythm	IEA

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

glutamate receptor signaling pathway [inference]

G protein-coupled glutamate receptor signaling pathway

G protein-coupled receptor signaling pathway [inference]

G protein-coupled glutamate receptor signaling pathway

cellular developmental process [inference]

cell development [inference]

muscle cell development [inference]

myotube cell development [inference]

skeletal muscle fiber development

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to cell junction [inference]

protein localization to synapse

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

protein-containing complex assembly [inference]

protein complex oligomerization [inference]

protein tetramerization

protein-containing complex organization [inference]

protein-containing complex assembly [inference]

protein complex oligomerization [inference]

protein tetramerization

postsynapse organization

multicellular organismal process [inference]

system process [inference]

muscle system process [inference]

muscle contraction [inference]

striated muscle contraction [inference]

skeletal muscle contraction

behavior [inference]

adult behavior [inference]

behavioral response to cocaine

developmental process [inference]

anatomical structure development [inference]

cell development [inference]

muscle cell development [inference]

myotube cell development [inference]

skeletal muscle fiber development

cellular developmental process [inference]

cell development [inference]

muscle cell development [inference]

myotube cell development [inference]

skeletal muscle fiber development

rhythmic process [inference]

circadian rhythm

response to stimulus [inference]

response to chemical [inference]

response to organic substance [inference]

response to calcium ion

response to inorganic substance [inference]

response to metal ion [inference]

response to calcium ion

response to nicotine

response to oxygen-containing compound [inference]

response to calcium ion

response to salt [inference]

response to calcium ion

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to cell junction [inference]

protein localization to synapse

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to cell junction [inference]

protein localization to synapse

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

regulation of signaling receptor activity [inference]

regulation of neurotransmitter receptor activity [inference]

regulation of postsynaptic neurotransmitter receptor activity

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

regulation of localization [inference]

regulation of transport [inference]

regulation of transmembrane transport [inference]

regulation of transmembrane transporter activity [inference]

regulation of monoatomic ion transmembrane transporter activity [inference]

regulation of cation channel activity

regulation of monoatomic ion transmembrane transport [inference]

regulation of monoatomic cation transmembrane transport [inference]

regulation of cation channel activity

regulation of monoatomic ion transport [inference]

regulation of metal ion transport [inference]

regulation of calcium ion transport [inference]

regulation of monoatomic ion transmembrane transport [inference]

regulation of monoatomic cation transmembrane transport [inference]

regulation of cation channel activity

positive regulation of monoatomic ion transport [inference]

positive regulation of calcium ion transport

positive regulation of transport [inference]

positive regulation of monoatomic ion transport [inference]

positive regulation of calcium ion transport

positive regulation of biological process [inference]

positive regulation of transport [inference]

positive regulation of monoatomic ion transport [inference]

positive regulation of calcium ion transport

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

regulation of signaling receptor activity [inference]

regulation of neurotransmitter receptor activity [inference]

regulation of postsynaptic neurotransmitter receptor activity

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

glutamate receptor signaling pathway [inference]

G protein-coupled glutamate receptor signaling pathway

G protein-coupled receptor signaling pathway [inference]

G protein-coupled glutamate receptor signaling pathway

regulation of cell communication [inference]

regulation of signal transduction [inference]

regulation of signaling receptor activity [inference]

regulation of neurotransmitter receptor activity [inference]

regulation of postsynaptic neurotransmitter receptor activity

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

regulation of transmembrane transport [inference]

regulation of transmembrane transporter activity [inference]

regulation of monoatomic ion transmembrane transporter activity [inference]

regulation of cation channel activity

regulation of monoatomic ion transmembrane transport [inference]

regulation of monoatomic cation transmembrane transport [inference]

regulation of cation channel activity

regulation of cellular component organization [inference]

regulation of cell projection organization [inference]

regulation of plasma membrane bounded cell projection organization [inference]

regulation of dendritic spine maintenance

regulation of synapse organization [inference]

regulation of postsynapse organization [inference]

regulation of dendritic spine maintenance

regulation of multicellular organismal process [inference]

regulation of system process [inference]

regulation of nervous system process [inference]

regulation of postsynaptic neurotransmitter receptor activity

regulation of molecular function [inference]

regulation of signaling receptor activity [inference]

regulation of neurotransmitter receptor activity [inference]

regulation of postsynaptic neurotransmitter receptor activity

regulation of transporter activity [inference]

regulation of transmembrane transporter activity [inference]

regulation of monoatomic ion transmembrane transporter activity [inference]

regulation of cation channel activity

Displaying entries **1 - 5** of 32 in total

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GO Term	Evidence Code	PMID
cytoplasm	IDA	12176012
cytoplasm	IBA
plasma membrane	IDA	12176012
plasma membrane	IBA
postsynaptic density	ISO

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytoplasm

cytosol [inference]

cytosolic region [inference]

postsynaptic cytosol

membrane

plasma membrane

Z disc

cell junction [inference]

synapse [inference]

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection

neuron spine

dendritic spine

organelle [inference]

postsynaptic specialization [inference]

postsynaptic density

cell body [inference]

neuronal cell body

apical part of cell

postsynapse

dendritic spine

Displaying entries **1 - 5** of 17 in total

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GO Term	Evidence Code	PMID
signaling receptor binding	ISO
protein binding	IPI	12176012 15579147 18268005 28469556 28671696 28701918 29111324
type 5 metabotropic glutamate receptor binding	ISO
type 5 metabotropic glutamate receptor binding	IEA
G protein-coupled glutamate receptor binding	ISO

GO Hierarchy

molecular function

structural molecule activity [inference]

structural constituent of synapse [inference]

structural constituent of postsynapse

binding [inference]

protein binding

signaling receptor binding

G protein-coupled receptor binding [inference]

G protein-coupled glutamate receptor binding

type 5 metabotropic glutamate receptor binding

glutamate receptor binding [inference]

G protein-coupled glutamate receptor binding

type 5 metabotropic glutamate receptor binding

protein-containing complex binding

molecular adaptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

homer

Functional Category

E: Amino acid transport and metabolism
J: Translation, ribosomal structure and biogenesis
T: Signal transduction mechanisms

Displaying **all 3** entries
Gene Ontology
G protein-coupled glutamate receptor binding
G protein-coupled glutamate receptor signaling pathway
regulation of store-operated calcium entry

Displaying **all 4** entries
InterPro
Homer family
Homer, EVH1 domain
PH-like domain superfamily
WH1/EVH1 domain

Ortholog

Displaying entries **1 - 10** of 92 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Drosophila melanogaster	9455	FB:FBgn0025777
Homo sapiens	9456		HUMAN79835
Xenopus tropicalis	26556	Xenbase:XB-GENE-5807410
Rattus norvegicus	29546		RATNO23229
Xenopus tropicalis	33944	Xenbase:XB-GENE-5807410
Ovis aries	443063		SHEEP17730
Pan troglodytes	471504		PANTR35218
Canis lupus familiaris	488933		CANLF11923
Bos taurus	535311		BOVIN00427
Macaca mulatta	709774		MACMU39083