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receptor tyrosine kinase-like orphan receptor 1

Summary

Gene Symbol

Ror1

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

26563

PubChem

26563

Alliance of Genome Resources

MGI:1347520

Annotation

Keyword

ATP-binding
Cell projection
Disulfide bond
Glycoprotein
Immunoglobulin domain
Kringle
Phosphoprotein
Receptor
Reference proteome
Signal
Transmembrane helix
Wnt signaling pathway

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q501P6
Q9Z139	Neurotrophic tyrosine kinase, receptor-related 1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 15 in total

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GO Term	Evidence Code	PMID
protein phosphorylation
transmembrane receptor protein tyrosine kinase signaling pathway	IBA
transmembrane receptor protein tyrosine kinase signaling pathway	IEA
sensory perception of sound	ISS
sensory perception of sound	ISO

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phosphorylation [inference]

protein phosphorylation

primary metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation

macromolecule modification [inference]

protein modification process [inference]

protein phosphorylation

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

transmembrane receptor protein tyrosine kinase signaling pathway

Wnt signaling pathway

cell population proliferation

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phosphorylation [inference]

protein phosphorylation

cellular developmental process [inference]

cell development [inference]

glial cell development [inference]

astrocyte development

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

sensory perception [inference]

sensory perception of mechanical stimulus [inference]

sensory perception of sound

developmental process [inference]

anatomical structure development [inference]

cell development [inference]

glial cell development [inference]

astrocyte development

inner ear development

cellular developmental process [inference]

cell development [inference]

glial cell development [inference]

astrocyte development

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of DNA-templated transcription [inference]

regulation of DNA-binding transcription factor activity [inference]

positive regulation of DNA-binding transcription factor activity [inference]

positive regulation of NF-kappaB transcription factor activity

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of DNA-binding transcription factor activity [inference]

positive regulation of DNA-binding transcription factor activity [inference]

positive regulation of NF-kappaB transcription factor activity

regulation of cellular metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of RNA metabolic process [inference]

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of DNA-binding transcription factor activity [inference]

positive regulation of DNA-binding transcription factor activity [inference]

positive regulation of NF-kappaB transcription factor activity

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of DNA-templated transcription [inference]

regulation of DNA-binding transcription factor activity [inference]

positive regulation of DNA-binding transcription factor activity [inference]

positive regulation of NF-kappaB transcription factor activity

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of DNA-binding transcription factor activity [inference]

positive regulation of DNA-binding transcription factor activity [inference]

positive regulation of NF-kappaB transcription factor activity

regulation of nitrogen compound metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of RNA metabolic process [inference]

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of DNA-binding transcription factor activity [inference]

positive regulation of DNA-binding transcription factor activity [inference]

positive regulation of NF-kappaB transcription factor activity

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of DNA-templated transcription [inference]

regulation of DNA-binding transcription factor activity [inference]

positive regulation of DNA-binding transcription factor activity [inference]

positive regulation of NF-kappaB transcription factor activity

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of DNA-binding transcription factor activity [inference]

positive regulation of DNA-binding transcription factor activity [inference]

positive regulation of NF-kappaB transcription factor activity

regulation of RNA metabolic process [inference]

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of DNA-binding transcription factor activity [inference]

positive regulation of DNA-binding transcription factor activity [inference]

positive regulation of NF-kappaB transcription factor activity

regulation of primary metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of RNA metabolic process [inference]

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of DNA-binding transcription factor activity [inference]

positive regulation of DNA-binding transcription factor activity [inference]

positive regulation of NF-kappaB transcription factor activity

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

regulation of intracellular signal transduction [inference]

regulation of canonical NF-kappaB signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

positive regulation of intracellular signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

regulation of intracellular signal transduction [inference]

regulation of canonical NF-kappaB signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

positive regulation of intracellular signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

transmembrane receptor protein tyrosine kinase signaling pathway

Wnt signaling pathway

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

regulation of intracellular signal transduction [inference]

regulation of canonical NF-kappaB signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

positive regulation of intracellular signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

regulation of cellular metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of RNA metabolic process [inference]

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of DNA-binding transcription factor activity [inference]

positive regulation of DNA-binding transcription factor activity [inference]

positive regulation of NF-kappaB transcription factor activity

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of DNA-templated transcription [inference]

regulation of DNA-binding transcription factor activity [inference]

positive regulation of DNA-binding transcription factor activity [inference]

positive regulation of NF-kappaB transcription factor activity

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of DNA-binding transcription factor activity [inference]

positive regulation of DNA-binding transcription factor activity [inference]

positive regulation of NF-kappaB transcription factor activity

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

regulation of molecular function [inference]

positive regulation of molecular function [inference]

positive regulation of DNA-binding transcription factor activity [inference]

positive regulation of NF-kappaB transcription factor activity

regulation of DNA-binding transcription factor activity [inference]

positive regulation of DNA-binding transcription factor activity [inference]

positive regulation of NF-kappaB transcription factor activity

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
stress fiber	ISO
stress fiber	IEA
plasma membrane	ISS	10231392
plasma membrane	ISO
plasma membrane	IBA

GO Hierarchy

cellular component

protein-containing complex [inference]

receptor complex

cellular anatomical entity [inference]

cell surface

membrane [inference]

plasma membrane

actin filament bundle [inference]

contractile actin filament bundle [inference]

stress fiber

actomyosin [inference]

stress fiber

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

axon

neuron projection terminus [inference]

axon terminus

presynapse [inference]

axon terminus

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
transmembrane receptor protein tyrosine kinase activity	TAS	10231392
transmembrane receptor protein tyrosine kinase activity	IBA
ATP binding	IEA
Wnt-protein binding	ISO
Wnt-protein binding	IBA

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring phosphorus-containing groups [inference]

kinase activity [inference]

protein kinase activity [inference]

protein tyrosine kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity

transmembrane receptor protein kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity

phosphotransferase activity, alcohol group as acceptor [inference]

protein kinase activity [inference]

protein tyrosine kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity

transmembrane receptor protein kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity

catalytic activity, acting on a protein [inference]

protein kinase activity [inference]

protein tyrosine kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity

transmembrane receptor protein kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity

binding [inference]

protein binding [inference]

Wnt-protein binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

transmembrane receptor protein kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity

Wnt receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

tyrosine-protein kinase

Functional Category

G: Carbohydrate transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 8** entries
Gene Ontology
ATP binding
Wnt-protein binding
kinase activity
nucleotide binding
phosphorylation
positive regulation of neuron projection development
transmembrane receptor protein tyrosine kinase activity
transmembrane receptor protein tyrosine kinase signaling pathway

Displaying entries **1 - 10** of 17 in total

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InterPro
Frizzled cysteine-rich domain superfamily
Frizzled domain
Immunoglobulin I-set
Immunoglobulin subtype 2
Immunoglobulin subtype
Immunoglobulin-like domain superfamily
Immunoglobulin-like domain
Immunoglobulin-like fold
Kringle superfamily
Kringle, conserved site

Ortholog

Displaying entries **1 - 10** of 90 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	4919	Xenbase:XB-GENE-490892	HUMAN50228
Drosophila melanogaster	4920	FB:FBgn0010407
Xenopus tropicalis	26563	Xenbase:XB-GENE-490892
Drosophila melanogaster	26564	FB:FBgn0010407
Xenopus tropicalis	34367	Xenbase:XB-GENE-490892
Xenopus tropicalis	174473	Xenbase:XB-GENE-490892
Rattus norvegicus	362550		RATNO33267
Pan troglodytes	456910		PANTR21281
Canis lupus familiaris	489557		CANLF15637
Danio rerio	568282		DANRE38660

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OrthoDB (Group)

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