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growth differentiation factor 10

Summary

Gene Symbol

GDF10

Organism

Homo sapiens (human)

External Links

NCBI Gene

2662

PubChem

2662

Alliance of Genome Resources

HGNC:4215

JoGo

GDF10

TogoVar

GDF10

Annotation

Keyword

Cleavage on pair of basic residues
Cytokine
Disulfide bond
Glycoprotein
Growth factor
Osteogenesis
Proteomics identification
Reference proteome
Secreted
Signal

Proteins

Displaying 1 entry
UniProt	Protein Name
P55107	Bone morphogenetic protein 3B Bone-inducing protein

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 10 in total

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2

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GO Term	Evidence Code	PMID
skeletal system development	TAS	8670277
osteoblast differentiation	IEA
transforming growth factor beta receptor signaling pathway	TAS	8679252
cerebellum development	IEA
regulation of ossification

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

transforming growth factor beta receptor superfamily signaling pathway [inference]

transforming growth factor beta receptor signaling pathway

cellular developmental process [inference]

cell differentiation [inference]

reproductive process [inference]

multicellular organismal reproductive process [inference]

ovulation cycle

developmental process [inference]

anatomical structure development [inference]

cerebellum development

system development [inference]

skeletal system development

cellular developmental process [inference]

cell differentiation [inference]

rhythmic process [inference]

ovulation cycle

response to stimulus [inference]

response to chemical [inference]

response to acid chemical [inference]

response to amino acid [inference]

response to kainic acid

response to organic substance [inference]

response to organonitrogen compound [inference]

response to amino acid [inference]

response to kainic acid

response to organic cyclic compound [inference]

response to kainic acid

response to nitrogen compound [inference]

response to organonitrogen compound [inference]

response to amino acid [inference]

response to kainic acid

response to oxygen-containing compound [inference]

response to amino acid [inference]

response to kainic acid

biological regulation [inference]

regulation of biological process [inference]

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cell differentiation [inference]

positive regulation of osteoblast differentiation

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of osteoblast differentiation

negative regulation of biological process [inference]

negative regulation of multicellular organismal process [inference]

negative regulation of ossification

regulation of developmental process [inference]

regulation of cell differentiation [inference]

positive regulation of cell differentiation [inference]

positive regulation of osteoblast differentiation

regulation of osteoblast differentiation [inference]

positive regulation of osteoblast differentiation

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of osteoblast differentiation

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

transforming growth factor beta receptor superfamily signaling pathway [inference]

transforming growth factor beta receptor signaling pathway

regulation of cell differentiation [inference]

positive regulation of cell differentiation [inference]

positive regulation of osteoblast differentiation

regulation of osteoblast differentiation [inference]

positive regulation of osteoblast differentiation

positive regulation of cellular process [inference]

positive regulation of cell differentiation [inference]

positive regulation of osteoblast differentiation

regulation of multicellular organismal process [inference]

regulation of ossification

negative regulation of ossification

negative regulation of multicellular organismal process [inference]

negative regulation of ossification

Displaying **all 2** entries
GO Term	Evidence Code	PMID
extracellular space	IBA
collagen-containing extracellular matrix	HDA	27068509

GO Hierarchy

cellular component

cellular anatomical entity [inference]

extracellular space

external encapsulating structure [inference]

extracellular matrix [inference]

collagen-containing extracellular matrix

Displaying **all 4** entries
GO Term	Evidence Code	PMID
cytokine activity	IC	22155034
cytokine activity	IBA
growth factor activity	IEA
protein serine/threonine kinase activator activity	IC	22155034

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

signaling receptor binding [inference]

receptor ligand activity [inference]

molecular function regulator activity [inference]

enzyme regulator activity [inference]

enzyme activator activity [inference]

kinase activator activity [inference]

protein kinase activator activity [inference]

protein serine/threonine kinase activator activity

kinase regulator activity [inference]

kinase activator activity [inference]

protein kinase activator activity [inference]

protein serine/threonine kinase activator activity

protein kinase regulator activity [inference]

protein kinase activator activity [inference]

protein serine/threonine kinase activator activity

signaling receptor regulator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity [inference]

molecular function activator activity [inference]

enzyme activator activity [inference]

kinase activator activity [inference]

protein kinase activator activity [inference]

protein serine/threonine kinase activator activity

signaling receptor activator activity [inference]

receptor ligand activity [inference]

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

bone morphogenetic protein 3

Functional Category

J: Translation, ribosomal structure and biogenesis
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 4** entries
Gene Ontology
cytokine activity
growth factor activity
osteoblast differentiation
positive regulation of osteoblast differentiation

Displaying **all 4** entries
InterPro
Cystine-knot cytokine
Transforming growth factor beta, conserved site
Transforming growth factor-beta, C-terminal
Transforming growth factor-beta-related