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Poly [ADP-ribose] polymerase;Poly [ADP-ribose] polymerase 1

Summary

Gene Symbol

parp-1

Organism

Caenorhabditis elegans

External Links

NCBI Gene

266823

PubChem

266823

Alliance of Genome Resources

WB:WBGene00004049

Annotation

Keyword

ADP-ribosylation
DNA repair
DNA-binding
Glycosyltransferase
NAD
Nucleotidyltransferase
Nucleus
Proteomics identification
Reference proteome
Repeat
Zinc-finger

Proteins

Displaying **all 4** entries
UniProt	Protein Name
A0A0K3AWQ2
A0A0K3AUD3
Q9N4H4	Poly ADP-ribose metabolism enzyme 1 Protein poly-ADP-ribosyltransferase parp-1
A0A0K3ARD5

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 4** entries
GO Term	Evidence Code	PMID
DNA repair	IEA
protein poly-ADP-ribosylation	IBA
determination of adult lifespan	IMP	23870130
double-strand break repair	IBA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

double-strand break repair

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

post-translational protein modification [inference]

protein poly-ADP-ribosylation

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

double-strand break repair

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

double-strand break repair

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

double-strand break repair

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

double-strand break repair

protein metabolic process [inference]

protein modification process [inference]

post-translational protein modification [inference]

protein poly-ADP-ribosylation

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

post-translational protein modification [inference]

protein poly-ADP-ribosylation

macromolecule modification [inference]

protein modification process [inference]

post-translational protein modification [inference]

protein poly-ADP-ribosylation

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

double-strand break repair

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

double-strand break repair

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

post-translational protein modification [inference]

protein poly-ADP-ribosylation

cellular process [inference]

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

double-strand break repair

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

double-strand break repair

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

double-strand break repair

cellular response to stimulus [inference]

cellular response to stress [inference]

DNA damage response [inference]

double-strand break repair

multicellular organismal process [inference]

determination of adult lifespan

response to stimulus [inference]

response to stress [inference]

cellular response to stress [inference]

DNA damage response [inference]

double-strand break repair

cellular response to stimulus [inference]

cellular response to stress [inference]

DNA damage response [inference]

double-strand break repair

Displaying **all 2** entries
GO Term	Evidence Code	PMID
nucleus	IEA
nucleolus	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

nucleolus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular non-membrane-bounded organelle [inference]

nucleolus

Displaying entries **1 - 5** of 8 in total

1

2

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GO Term	Evidence Code	PMID
zinc ion binding	IEA
NAD binding	IEA
DNA binding	IEA
NAD+-protein ADP-ribosyltransferase activity	IBA
NAD+ ADP-ribosyltransferase activity	IBA IDA IEA IMP	12145714 15923155 23870130

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

glycosyltransferase activity

pentosyltransferase activity [inference]

transferase activity, transferring phosphorus-containing groups [inference]

nucleotidyltransferase activity

catalytic activity, acting on a protein [inference]

NAD+-protein ADP-ribosyltransferase activity

binding [inference]

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

NAD binding

ion binding [inference]

cation binding [inference]

metal ion binding

transition metal ion binding [inference]

zinc ion binding

organic cyclic compound binding [inference]

nucleic acid binding [inference]

DNA binding

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

NAD binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

poly

Functional Category

K: Transcription
L: Replication, recombination and repair
T: Signal transduction mechanisms

Displaying **all 3** entries
Gene Ontology
NAD+ ADP-ribosyltransferase activity
metal ion binding
zinc ion binding

Displaying **all 2** entries
InterPro
Zinc finger, PARP-type superfamily
Zinc finger, PARP-type

Disease

Disease Ontology

Displaying entries **1 - 10** of 21 in total

1

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3

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DO ID	Disease Name	Source
DOID:0050156	idiopathic pulmonary fibrosis	Alliance of Genome Resources
DOID:10534	stomach cancer	Alliance of Genome Resources
DOID:10652	Alzheimer's disease	Alliance of Genome Resources
DOID:1074	kidney failure	Alliance of Genome Resources
DOID:10952	nephritis	Alliance of Genome Resources
DOID:127	leiomyoma	Alliance of Genome Resources
DOID:12858	Huntington's disease	Alliance of Genome Resources
DOID:14330	Parkinson's disease	Alliance of Genome Resources
DOID:224	transient cerebral ischemia	Alliance of Genome Resources
DOID:2841	asthma	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 12 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	142		HGNC:270
Mus musculus	11545		MGI:1340806
Rattus norvegicus	25591		RGD:2053
Danio rerio	560788		ZFIN:ZDB-GENE-030131-3955
Drosophila melanogaster	3355109		FB:FBgn0010247
Brugia malayi	6105066	6279_0:001aed
Caenorhabditis remanei	9824349	31234_0:002587
Loa loa	9940767	7209_0:000f9e
Necator americanus	25352003	51031_0:002bf4
Necator americanus	25352004	51031_0:002bfb

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Last updated: December 9, 2024