gamma-glutamyltransferase 1

Summary
Gene Symbol
  • GGT1
Organism
Homo sapiens (human)
External Links
NCBI Gene
2678
KEGG Gene ID
hsa:2678
PubChem
2678
Alliance of Genome Resources
Annotation
Keyword
  • 3D-structure
  • Acyltransferase
  • Alternative promoter usage
  • Alternative splicing
  • Cell membrane
  • Direct protein sequencing
  • Disease variant
  • Disulfide bond
  • Glutathione biosynthesis
  • Hydrolase
  • Intellectual disability
  • Lipid metabolism
  • Protease
  • Reference proteome
  • Sialic acid
  • Signal-anchor
  • Transmembrane helix
  • Zymogen
Proteins
Displaying all 2 entries
UniProt Protein Name
P19440
  • Gamma-glutamyltransferase 1
  • Gamma-glutamyltranspeptidase 1
  • Leukotriene-C4 hydrolase
A0A140VJJ9
  • Gamma-glutamyltransferase
  • Gamma-glutamyltranspeptidase
Gene Ontology (GO)
GO Hierarchy
Human Protein Atlas
ENSG00000100031

soft tissue soft tissue blood blood blood blood blood blood blood blood blood blood blood blood blood blood lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node kidney kidney adrenal gland adrenal gland breast breast duodenum stomach small intestine colon rectum appendix esophagus eye eye salivary gland nasopharynx nasopharynx tongue tonsil tonsil tonsil hair skin adipose tissue adipose tissue adipose tissue spinal cord oral mucosa lung lung heart bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus liver pancreas thyroid gland parathyroid gland parathyroid gland parathyroid gland parathyroid gland parathyroid gland spleen gallbladder ductus deferens ductus deferens seminal vesicle seminal vesicle seminal vesicle seminal vesicle testis testis epididymis epididymis brain smooth muscle urinary bladder prostate bone marrow skeletal muscle skeletal muscle skeletal muscle skeletal muscle skeletal muscle thymus thymus cartilage sole of foot sole of foot soft tissue blood blood blood blood blood blood blood blood blood blood blood blood lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lactating breast lactating breast kidney kidney adrenal gland adrenal gland duodenum stomach small intestine colon rectum appendix esophagus eye eye salivary gland salivary gland salivary gland salivary gland salivary gland salivary gland nasopharynx tongue tonsil tonsil hair skin adipose tissue adipose tissue adipose tissue adipose tissue adipose tissue adipose tissue adipose tissue spinal cord oral mucosa lung lung heart bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus liver pancreas thyroid gland parathyroid gland parathyroid gland parathyroid gland parathyroid gland parathyroid gland spleen gallbladder brain skeletal muscle skeletal muscle skeletal muscle skeletal muscle skeletal muscle thymus thymus smooth muscle urinary bladder vagina ovary ovary fallopian tube fallopian tube endometrium placenta cervix cervix bone marrow cartilage sole of foot sole of foot olfactory region cerebral cortex cerebellum medulla pons midbrain pituitary gland hypothalamus amygdala thalamus choroid plexus choroid plexus corpus callosum basal ganglia substantia nigra dorsal raphe dorsal raphe dorsal raphe dorsal raphe dorsal raphe dorsal raphe caudate hippocampus retina retina

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

KEGG BRITE Database
Orthology
K18592
Name
gamma-glutamyltranspeptidase / glutathione hydrolase / leukotriene-C4 hydrolase [EC:2.3.2.2 3.4.19.13 3.4.19.14]
References
Disease
Disease Ontology
Displaying entries 31 - 40 of 202 in total
DO ID Disease Name Source
DOID:0110044 Alzheimer's disease 11
DOID:0110045 Alzheimer's disease 12
DOID:0110046 Alzheimer's disease 13
DOID:0110047 Alzheimer's disease 14
DOID:0110048 Alzheimer's disease 15
DOID:0111257 gamma-glutamyl transpeptidase deficiency
DOID:0111353 arthrogryposis, renal dysfunction, and cholestasis 1
DOID:10283 prostate cancer
DOID:10286 prostate carcinoma
DOID:10320 asbestosis
The Human Phenotype Ontology
Displaying entries 11 - 16 of 16 in total
HPO ID HPO Term
HP:0002019 Constipation
HP:0002075 Dysdiadochokinesis
HP:0002099 Asthma
HP:0002282 Gray matter heterotopia
HP:0002345 Action tremor
HP:0003593 Infantile onset
Displaying 1 entry
Disease ID Disease Name
OMIM:231950
  • gamma-glutamyl transpeptidase deficiency
LIPID MAPS Gene / Proteome Database
LMPD ID
LMP001635
Gene Name
gamma-glutamyltransferase 1

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01


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Last updated: August 19, 2024