GlyCosmos Portal

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GO Term	Evidence Code	PMID
protein binding	IPI	32296183
ATP binding	IEA
5-oxoprolinase (ATP-hydrolyzing) activity	ISS
5-oxoprolinase (ATP-hydrolyzing) activity	TAS
5-oxoprolinase (ATP-hydrolyzing) activity	IBA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds [inference]

hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides [inference]

5-oxoprolinase (ATP-hydrolyzing) activity

binding [inference]

protein binding

identical protein binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

oxoprolinase

Functional Category

E: Amino acid transport and metabolism
I: Lipid transport and metabolism
K: Transcription
Q: Secondary metabolites biosynthesis, transport and catabolism

Displaying **all 4** entries
Gene Ontology
5-oxoprolinase (ATP-hydrolyzing) activity
catalytic activity
glutathione metabolic process
hydrolase activity

Displaying **all 5** entries
InterPro
Acetophenone carboxylase-like, C-terminal domain
Hydantoinase A/oxoprolinase
Hydantoinase B/oxoprolinase
Hydantoinase/oxoprolinase, N-terminal
Oxoprolinase family

Rhea

RHEA:10348

H₂O + ATP + 5-oxo-L-proline

H⁺ + L-glutamate + phosphate + ADP

Enzyme

3.5.2.9

PMID

Disease

The Human Phenotype Ontology

Displaying **all 8** entries
HPO ID	HPO Term
HP:0000006	Autosomal dominant inheritance
HP:0000007	Autosomal recessive inheritance
HP:0002013	Vomiting
HP:0002014	Diarrhea
HP:0002027	Abdominal pain
HP:0003137	Prolinuria
HP:0004387	Enterocolitis
HP:0008672	Calcium oxalate nephrolithiasis