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gulonolactone (L-) oxidase

Summary

Gene Symbol

Gulo

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

268756

PubChem

268756

Alliance of Genome Resources

MGI:1353434

Annotation

Keyword

Ascorbate biosynthesis
Direct protein sequencing
FAD
Microsome
Oxidoreductase
Reference proteome
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
P58710	L-gulono-gamma-lactone oxidase

Annotation information from UniProt.

Gene Ontology (GO)

Displaying 1 entry
GO Term	Evidence Code	PMID
L-ascorbic acid biosynthetic process	IDA IMP	10606751 10639167 14962674

GO Hierarchy

biological process

metabolic process [inference]

biosynthetic process [inference]

cellular biosynthetic process [inference]

vitamin biosynthetic process [inference]

water-soluble vitamin biosynthetic process [inference]

L-ascorbic acid biosynthetic process

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

L-ascorbic acid biosynthetic process

heterocycle biosynthetic process [inference]

lactone biosynthetic process [inference]

L-ascorbic acid biosynthetic process

small molecule biosynthetic process [inference]

vitamin biosynthetic process [inference]

water-soluble vitamin biosynthetic process [inference]

L-ascorbic acid biosynthetic process

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

L-ascorbic acid biosynthetic process

monosaccharide biosynthetic process [inference]

L-ascorbic acid biosynthetic process

organic substance biosynthetic process [inference]

carbohydrate biosynthetic process [inference]

monosaccharide biosynthetic process [inference]

L-ascorbic acid biosynthetic process

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

L-ascorbic acid biosynthetic process

organic cyclic compound biosynthetic process [inference]

lactone biosynthetic process [inference]

L-ascorbic acid biosynthetic process

cellular metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

L-ascorbic acid biosynthetic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

L-ascorbic acid metabolic process [inference]

L-ascorbic acid biosynthetic process

carboxylic acid biosynthetic process [inference]

L-ascorbic acid biosynthetic process

cellular biosynthetic process [inference]

vitamin biosynthetic process [inference]

water-soluble vitamin biosynthetic process [inference]

L-ascorbic acid biosynthetic process

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

L-ascorbic acid biosynthetic process

heterocycle biosynthetic process [inference]

lactone biosynthetic process [inference]

L-ascorbic acid biosynthetic process

heterocycle metabolic process [inference]

heterocycle biosynthetic process [inference]

lactone biosynthetic process [inference]

L-ascorbic acid biosynthetic process

lactone metabolic process [inference]

L-ascorbic acid metabolic process [inference]

L-ascorbic acid biosynthetic process

lactone biosynthetic process [inference]

L-ascorbic acid biosynthetic process

primary metabolic process [inference]

carbohydrate metabolic process [inference]

monosaccharide metabolic process [inference]

L-ascorbic acid metabolic process [inference]

L-ascorbic acid biosynthetic process

monosaccharide biosynthetic process [inference]

L-ascorbic acid biosynthetic process

carbohydrate biosynthetic process [inference]

monosaccharide biosynthetic process [inference]

L-ascorbic acid biosynthetic process

small molecule metabolic process [inference]

monosaccharide metabolic process [inference]

L-ascorbic acid metabolic process [inference]

L-ascorbic acid biosynthetic process

monosaccharide biosynthetic process [inference]

L-ascorbic acid biosynthetic process

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

L-ascorbic acid biosynthetic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

L-ascorbic acid metabolic process [inference]

L-ascorbic acid biosynthetic process

carboxylic acid biosynthetic process [inference]

L-ascorbic acid biosynthetic process

vitamin metabolic process [inference]

water-soluble vitamin metabolic process [inference]

L-ascorbic acid metabolic process [inference]

L-ascorbic acid biosynthetic process

water-soluble vitamin biosynthetic process [inference]

L-ascorbic acid biosynthetic process

vitamin biosynthetic process [inference]

water-soluble vitamin biosynthetic process [inference]

L-ascorbic acid biosynthetic process

small molecule biosynthetic process [inference]

vitamin biosynthetic process [inference]

water-soluble vitamin biosynthetic process [inference]

L-ascorbic acid biosynthetic process

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

L-ascorbic acid biosynthetic process

monosaccharide biosynthetic process [inference]

L-ascorbic acid biosynthetic process

organic substance metabolic process [inference]

carbohydrate metabolic process [inference]

monosaccharide metabolic process [inference]

L-ascorbic acid metabolic process [inference]

L-ascorbic acid biosynthetic process

monosaccharide biosynthetic process [inference]

L-ascorbic acid biosynthetic process

carbohydrate biosynthetic process [inference]

monosaccharide biosynthetic process [inference]

L-ascorbic acid biosynthetic process

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

L-ascorbic acid biosynthetic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

L-ascorbic acid metabolic process [inference]

L-ascorbic acid biosynthetic process

carboxylic acid biosynthetic process [inference]

L-ascorbic acid biosynthetic process

organic cyclic compound metabolic process [inference]

lactone metabolic process [inference]

L-ascorbic acid metabolic process [inference]

L-ascorbic acid biosynthetic process

lactone biosynthetic process [inference]

L-ascorbic acid biosynthetic process

organic cyclic compound biosynthetic process [inference]

lactone biosynthetic process [inference]

L-ascorbic acid biosynthetic process

organic substance biosynthetic process [inference]

carbohydrate biosynthetic process [inference]

monosaccharide biosynthetic process [inference]

L-ascorbic acid biosynthetic process

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

L-ascorbic acid biosynthetic process

organic cyclic compound biosynthetic process [inference]

lactone biosynthetic process [inference]

L-ascorbic acid biosynthetic process

cellular process [inference]

cellular metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

L-ascorbic acid biosynthetic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

L-ascorbic acid metabolic process [inference]

L-ascorbic acid biosynthetic process

carboxylic acid biosynthetic process [inference]

L-ascorbic acid biosynthetic process

cellular biosynthetic process [inference]

vitamin biosynthetic process [inference]

water-soluble vitamin biosynthetic process [inference]

L-ascorbic acid biosynthetic process

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

L-ascorbic acid biosynthetic process

heterocycle biosynthetic process [inference]

lactone biosynthetic process [inference]

L-ascorbic acid biosynthetic process

heterocycle metabolic process [inference]

heterocycle biosynthetic process [inference]

lactone biosynthetic process [inference]

L-ascorbic acid biosynthetic process

lactone metabolic process [inference]

L-ascorbic acid metabolic process [inference]

L-ascorbic acid biosynthetic process

lactone biosynthetic process [inference]

L-ascorbic acid biosynthetic process

Displaying **all 5** entries
GO Term	Evidence Code	PMID
intracellular membrane-bounded organelle	IEA
endoplasmic reticulum	IEA
endoplasmic reticulum membrane
membrane	IEA
mitochondrion

GO Hierarchy

cellular component

cellular anatomical entity [inference]

organelle membrane [inference]

endoplasmic reticulum membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle

intracellular organelle [inference]

intracellular membrane-bounded organelle

Displaying entries **1 - 5** of 7 in total

1

2

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GO Term	Evidence Code	PMID
L-gulono-1,4-lactone dehydrogenase activity
oxidoreductase activity	IBA
D-arabinono-1,4-lactone oxidase activity	IEA
flavin adenine dinucleotide binding	IDA	14962674
L-gulonolactone oxidase activity	IDA IMP ISO	10606751 14962674 20410296

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity

oxidoreductase activity, acting on CH-OH group of donors [inference]

oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor

oxidoreductase activity, acting on the CH-CH group of donors [inference]

oxidoreductase activity, acting on the CH-CH group of donors, cytochrome as acceptor [inference]

L-gulono-1,4-lactone dehydrogenase activity

binding [inference]

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

flavin adenine dinucleotide binding

FAD binding

ion binding [inference]

anion binding [inference]

flavin adenine dinucleotide binding

FAD binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

flavin adenine dinucleotide binding

FAD binding

Gene Ontology information from NCBI Gene and UniProt.

Ortholog

Displaying entries **1 - 10** of 28 in total

1

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3

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Last »
Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Crocodylus porosus	109311561		CROPO09411
Sarcophilus harrisii	100931979		SARHA06052
Homo sapiens	2989	HGNC:4695
Canis lupus familiaris	486100		CANLF09966
Vulpes vulpes	112926784		VULVU21129
Ailuropoda melanoleuca	100478547		AILME17649
Mustela putorius furo	101690348		MUSPF03719
Felis catus	101092602		FELCA08535
Balaenoptera musculus	118896333		BALMU12914
Loxodonta africana	100658302		LOXAF12111

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: August 19, 2024