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MIRAGE

Rac GTPase-activating protein 1

Summary

Gene Symbol

Racgap1

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

26934

PubChem

26934

Alliance of Genome Resources

MGI:1349423

Annotation

Keyword

Acetylation
Cell division
Cell membrane
Coiled coil
Cytoplasmic vesicle
Cytoskeleton
Developmental protein
GTPase activation
Ion transport
Isopeptide bond
Lipid-binding
Nucleus
Phosphoprotein
Reference proteome
Spermatogenesis
Ubl conjugation
Zinc-finger

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9WVM1	Male germ cell RacGap

Annotation information from UniProt.

Gene Ontology (GO)

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GO Term	Evidence Code	PMID
mitotic cytokinesis	ISS
mitotic cytokinesis	ISO
mitotic cytokinesis	IBA
actomyosin contractile ring assembly	ISS
actomyosin contractile ring assembly	ISO

GO Hierarchy

biological process

cellular process [inference]

microtubule-based process [inference]

spindle midzone assembly [inference]

mitotic spindle midzone assembly

signal transduction

intracellular signal transduction [inference]

small GTPase mediated signal transduction [inference]

Ras protein signal transduction [inference]

Rho protein signal transduction

cell population proliferation [inference]

neural precursor cell proliferation [inference]

neuroblast proliferation

cell cycle process [inference]

cytokinesis [inference]

cytoskeleton-dependent cytokinesis [inference]

mitotic cytokinesis

cytokinetic process [inference]

assembly of actomyosin apparatus involved in cytokinesis [inference]

actomyosin contractile ring assembly

actomyosin contractile ring organization [inference]

actomyosin contractile ring assembly

spindle midzone assembly [inference]

mitotic spindle midzone assembly

mitotic cell cycle process [inference]

actin filament-based process [inference]

actin cytoskeleton organization [inference]

cortical actin cytoskeleton organization [inference]

actomyosin contractile ring organization [inference]

actomyosin contractile ring assembly

actomyosin structure organization [inference]

actomyosin contractile ring organization [inference]

actomyosin contractile ring assembly

cellular developmental process [inference]

cell differentiation [inference]

myeloid cell differentiation [inference]

erythrocyte differentiation

transmembrane transport [inference]

inorganic ion transmembrane transport [inference]

inorganic anion transmembrane transport [inference]

sulfate transmembrane transport

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

cytoskeleton organization [inference]

actin cytoskeleton organization [inference]

cortical actin cytoskeleton organization [inference]

actomyosin contractile ring organization [inference]

actomyosin contractile ring assembly

actomyosin structure organization [inference]

actomyosin contractile ring organization [inference]

actomyosin contractile ring assembly

cortical cytoskeleton organization [inference]

cortical actin cytoskeleton organization [inference]

actomyosin contractile ring organization [inference]

actomyosin contractile ring assembly

cellular component assembly [inference]

assembly of actomyosin apparatus involved in cytokinesis [inference]

actomyosin contractile ring assembly

spindle midzone assembly [inference]

mitotic spindle midzone assembly

reproductive process [inference]

developmental process involved in reproduction [inference]

spermatogenesis

multicellular organismal reproductive process [inference]

gamete generation [inference]

male gamete generation [inference]

spermatogenesis

developmental process [inference]

developmental process involved in reproduction [inference]

spermatogenesis

cellular developmental process [inference]

cell differentiation [inference]

myeloid cell differentiation [inference]

erythrocyte differentiation

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport

inorganic anion transport [inference]

sulfate transport

sulfate transmembrane transport

inorganic anion transmembrane transport [inference]

sulfate transmembrane transport

transmembrane transport [inference]

inorganic ion transmembrane transport [inference]

inorganic anion transmembrane transport [inference]

sulfate transmembrane transport

nitrogen compound transport [inference]

sulfate transport

sulfate transmembrane transport

sulfur compound transport [inference]

sulfate transport

sulfate transmembrane transport

biological regulation [inference]

regulation of biological process [inference]

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cell cycle [inference]

positive regulation of cell cycle process [inference]

positive regulation of cytokinesis

positive regulation of cell division [inference]

positive regulation of cytokinesis

regulation of developmental process [inference]

regulation of multicellular organismal development [inference]

regulation of embryonic development

regulation of cellular process [inference]

signal transduction

intracellular signal transduction [inference]

small GTPase mediated signal transduction [inference]

Ras protein signal transduction [inference]

Rho protein signal transduction

positive regulation of cellular process [inference]

positive regulation of cell cycle [inference]

positive regulation of cell cycle process [inference]

positive regulation of cytokinesis

positive regulation of cell division [inference]

positive regulation of cytokinesis

regulation of cell division [inference]

regulation of cytokinesis [inference]

positive regulation of cytokinesis

positive regulation of cell division [inference]

positive regulation of cytokinesis

regulation of cell cycle [inference]

regulation of cell cycle process [inference]

regulation of cytokinesis [inference]

positive regulation of cytokinesis

regulation of attachment of spindle microtubules to kinetochore

positive regulation of cell cycle process [inference]

positive regulation of cytokinesis

positive regulation of cell cycle [inference]

positive regulation of cell cycle process [inference]

positive regulation of cytokinesis

regulation of multicellular organismal process [inference]

regulation of multicellular organismal development [inference]

regulation of embryonic development

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GO Term	Evidence Code	PMID
acrosomal vesicle	IEA
nucleus	ISS
nucleus	ISO
nucleus	IBA
nucleoplasm	ISO

GO Hierarchy

cellular component

protein-containing complex [inference]

intracellular protein-containing complex [inference]

centralspindlin complex

cellular anatomical entity [inference]

nucleoplasm

membrane [inference]

plasma membrane region [inference]

cleavage furrow

midbody

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

secretory vesicle [inference]

secretory granule [inference]

acrosomal vesicle

intracellular membrane-bounded organelle [inference]

nucleus

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

secretory vesicle [inference]

secretory granule [inference]

acrosomal vesicle

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

mitotic spindle

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

secretory vesicle [inference]

secretory granule [inference]

acrosomal vesicle

intracellular non-membrane-bounded organelle [inference]

mitotic spindle

side of membrane [inference]

cytoplasmic side of membrane [inference]

cytoplasmic side of plasma membrane

Displaying entries **1 - 5** of 19 in total

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GO Term	Evidence Code	PMID
GTPase activator activity	ISS
GTPase activator activity	ISO
GTPase activator activity	IBA
phosphatidylinositol-3,4,5-trisphosphate binding	ISS
phosphatidylinositol-3,4,5-trisphosphate binding	ISO

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

cytoskeletal protein binding [inference]

tubulin binding [inference]

enzyme binding [inference]

kinase binding [inference]

protein kinase binding

lipid binding [inference]

phospholipid binding [inference]

phosphatidylinositol binding [inference]

phosphatidylinositol phosphate binding [inference]

phosphatidylinositol-3,4,5-trisphosphate binding

ion binding [inference]

anion binding [inference]

phosphatidylinositol-3,4,5-trisphosphate binding

cation binding [inference]

metal ion binding

transition metal ion binding [inference]

zinc ion binding

molecular adaptor activity [inference]

protein-macromolecule adaptor activity

molecular function regulator activity [inference]

enzyme regulator activity [inference]

enzyme activator activity [inference]

GTPase activator activity

nucleoside-triphosphatase regulator activity [inference]

GTPase regulator activity [inference]

GTPase activator activity

molecular function activator activity [inference]

enzyme activator activity [inference]

GTPase activator activity

Gene Ontology information from NCBI Gene and UniProt.

Ortholog

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Rhinopithecus roxellana	104679698		RHIRO14939
Pteropus vampyrus	105297555		PTEVA11910
Macaca nemestrina	105492857		MACNE43342
Mandrillus leucophaeus	105528069		MANLE15685
Cercocebus atys	105580363		CERAT25148
Propithecus coquereli	105818197		PROCO09241
Equus asinus asinus	106845053		EQUAS16771
Sinocyclocheilus grahami	107594001		SINGR22923
Sinocyclocheilus grahami	107599350		SINGR17102
Ictalurus punctatus	108275661		ICTPU07074

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: February 17, 2025