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cytoplasmic FMR1 interacting protein 2

Summary

Gene Symbol

CYFIP2

Organism

Homo sapiens (human)

External Links

NCBI Gene

26999

PubChem

26999

Alliance of Genome Resources

HGNC:13760

Annotation

Keyword

Acetylation
Alternative splicing
Apoptosis
Cell adhesion
Cytoplasm
Disease variant
Epilepsy
Nucleus
Proteomics identification
RNA editing
Reference proteome
Synaptosome

Proteins

Displaying **all 3** entries
UniProt	Protein Name
E7EVJ5
B7Z8N7
Q96F07	p53-inducible protein 121

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
cell-cell adhesion	IDA	15048733
cell morphogenesis	IBA
dendrite extension	IEA
positive regulation of proteolysis	IDA	18387192
apoptotic process	IBA IDA	10449408

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

protein processing [inference]

zymogen activation [inference]

activation of cysteine-type endopeptidase activity

protein maturation [inference]

protein processing [inference]

zymogen activation [inference]

activation of cysteine-type endopeptidase activity

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

protein processing [inference]

zymogen activation [inference]

activation of cysteine-type endopeptidase activity

protein maturation [inference]

protein processing [inference]

zymogen activation [inference]

activation of cysteine-type endopeptidase activity

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

protein processing [inference]

zymogen activation [inference]

activation of cysteine-type endopeptidase activity

protein maturation [inference]

protein processing [inference]

zymogen activation [inference]

activation of cysteine-type endopeptidase activity

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

protein processing [inference]

zymogen activation [inference]

activation of cysteine-type endopeptidase activity

protein maturation [inference]

protein processing [inference]

zymogen activation [inference]

activation of cysteine-type endopeptidase activity

cellular process [inference]

cell adhesion [inference]

cell-cell adhesion

cell death [inference]

programmed cell death [inference]

apoptotic process

cell growth [inference]

developmental cell growth [inference]

neuron projection extension [inference]

dendrite extension

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

cell projection assembly

cell projection organization [inference]

cell projection assembly

plasma membrane bounded cell projection organization [inference]

neuron projection development [inference]

neuron projection guidance [inference]

axon guidance

regulation of cellular component size [inference]

regulation of actin filament length [inference]

regulation of actin polymerization or depolymerization [inference]

regulation of actin filament polymerization

developmental process [inference]

anatomical structure morphogenesis [inference]

cell morphogenesis

growth [inference]

cell growth [inference]

developmental cell growth [inference]

neuron projection extension [inference]

dendrite extension

developmental growth [inference]

developmental cell growth [inference]

neuron projection extension [inference]

dendrite extension

developmental growth involved in morphogenesis [inference]

neuron projection extension [inference]

dendrite extension

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

positive regulation of metabolic process [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of proteolysis

positive regulation of peptidase activity [inference]

positive regulation of endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity [inference]

activation of cysteine-type endopeptidase activity

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of proteolysis

positive regulation of peptidase activity [inference]

positive regulation of endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity [inference]

activation of cysteine-type endopeptidase activity

regulation of nitrogen compound metabolic process [inference]

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of proteolysis

positive regulation of peptidase activity [inference]

positive regulation of endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity [inference]

activation of cysteine-type endopeptidase activity

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

positive regulation of proteolysis

positive regulation of peptidase activity [inference]

positive regulation of endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity [inference]

activation of cysteine-type endopeptidase activity

regulation of peptidase activity [inference]

positive regulation of peptidase activity [inference]

positive regulation of endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity [inference]

activation of cysteine-type endopeptidase activity

regulation of endopeptidase activity [inference]

positive regulation of endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity [inference]

activation of cysteine-type endopeptidase activity

regulation of cysteine-type endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity [inference]

activation of cysteine-type endopeptidase activity

positive regulation of protein metabolic process [inference]

positive regulation of proteolysis

positive regulation of peptidase activity [inference]

positive regulation of endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity [inference]

activation of cysteine-type endopeptidase activity

regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of proteolysis

positive regulation of peptidase activity [inference]

positive regulation of endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity [inference]

activation of cysteine-type endopeptidase activity

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

positive regulation of proteolysis

positive regulation of peptidase activity [inference]

positive regulation of endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity [inference]

activation of cysteine-type endopeptidase activity

regulation of peptidase activity [inference]

positive regulation of peptidase activity [inference]

positive regulation of endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity [inference]

activation of cysteine-type endopeptidase activity

regulation of endopeptidase activity [inference]

positive regulation of endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity [inference]

activation of cysteine-type endopeptidase activity

regulation of cysteine-type endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity [inference]

activation of cysteine-type endopeptidase activity

positive regulation of protein metabolic process [inference]

positive regulation of proteolysis

positive regulation of peptidase activity [inference]

positive regulation of endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity [inference]

activation of cysteine-type endopeptidase activity

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

positive regulation of proteolysis

positive regulation of peptidase activity [inference]

positive regulation of endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity [inference]

activation of cysteine-type endopeptidase activity

regulation of peptidase activity [inference]

positive regulation of peptidase activity [inference]

positive regulation of endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity [inference]

activation of cysteine-type endopeptidase activity

regulation of endopeptidase activity [inference]

positive regulation of endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity [inference]

activation of cysteine-type endopeptidase activity

regulation of cysteine-type endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity [inference]

activation of cysteine-type endopeptidase activity

positive regulation of protein metabolic process [inference]

positive regulation of proteolysis

positive regulation of peptidase activity [inference]

positive regulation of endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity [inference]

activation of cysteine-type endopeptidase activity

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of neurotrophin TRK receptor signaling pathway

regulation of neurotrophin TRK receptor signaling pathway [inference]

positive regulation of neurotrophin TRK receptor signaling pathway

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of neurotrophin TRK receptor signaling pathway

positive regulation of biological process [inference]

positive regulation of metabolic process [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of proteolysis

positive regulation of peptidase activity [inference]

positive regulation of endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity [inference]

activation of cysteine-type endopeptidase activity

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of proteolysis

positive regulation of peptidase activity [inference]

positive regulation of endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity [inference]

activation of cysteine-type endopeptidase activity

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of neurotrophin TRK receptor signaling pathway

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of neurotrophin TRK receptor signaling pathway

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of neurotrophin TRK receptor signaling pathway

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of neurotrophin TRK receptor signaling pathway

regulation of neurotrophin TRK receptor signaling pathway [inference]

positive regulation of neurotrophin TRK receptor signaling pathway

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of neurotrophin TRK receptor signaling pathway

regulation of cellular response to growth factor stimulus [inference]

regulation of neurotrophin TRK receptor signaling pathway [inference]

positive regulation of neurotrophin TRK receptor signaling pathway

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of neurotrophin TRK receptor signaling pathway

regulation of neurotrophin TRK receptor signaling pathway [inference]

positive regulation of neurotrophin TRK receptor signaling pathway

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of neurotrophin TRK receptor signaling pathway

regulation of actin filament-based process [inference]

regulation of actin cytoskeleton organization [inference]

regulation of actin filament length [inference]

regulation of actin polymerization or depolymerization [inference]

regulation of actin filament polymerization

regulation of actin filament organization [inference]

regulation of actin polymerization or depolymerization [inference]

regulation of actin filament polymerization

regulation of cellular component biogenesis [inference]

regulation of protein-containing complex assembly [inference]

regulation of protein polymerization [inference]

regulation of actin filament polymerization

regulation of cell junction assembly [inference]

regulation of synapse assembly [inference]

regulation of postsynapse assembly

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of neurotrophin TRK receptor signaling pathway

regulation of cellular component organization [inference]

regulation of organelle organization [inference]

regulation of cytoskeleton organization [inference]

regulation of actin cytoskeleton organization [inference]

regulation of actin filament length [inference]

regulation of actin polymerization or depolymerization [inference]

regulation of actin filament polymerization

regulation of actin filament organization [inference]

regulation of actin polymerization or depolymerization [inference]

regulation of actin filament polymerization

regulation of protein-containing complex assembly [inference]

regulation of protein polymerization [inference]

regulation of actin filament polymerization

regulation of synapse organization [inference]

regulation of synapse assembly [inference]

regulation of postsynapse assembly

regulation of postsynapse organization [inference]

regulation of postsynapse assembly

regulation of cell junction assembly [inference]

regulation of synapse assembly [inference]

regulation of postsynapse assembly

regulation of supramolecular fiber organization [inference]

regulation of actin filament organization [inference]

regulation of actin polymerization or depolymerization [inference]

regulation of actin filament polymerization

regulation of biological quality [inference]

regulation of anatomical structure size [inference]

regulation of cellular component size [inference]

regulation of actin filament length [inference]

regulation of actin polymerization or depolymerization [inference]

regulation of actin filament polymerization

regulation of molecular function [inference]

positive regulation of molecular function [inference]

positive regulation of catalytic activity [inference]

positive regulation of hydrolase activity [inference]

positive regulation of peptidase activity [inference]

positive regulation of endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity [inference]

activation of cysteine-type endopeptidase activity

regulation of catalytic activity [inference]

positive regulation of catalytic activity [inference]

positive regulation of hydrolase activity [inference]

positive regulation of peptidase activity [inference]

positive regulation of endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity [inference]

activation of cysteine-type endopeptidase activity

regulation of hydrolase activity [inference]

positive regulation of hydrolase activity [inference]

positive regulation of peptidase activity [inference]

positive regulation of endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity [inference]

activation of cysteine-type endopeptidase activity

regulation of peptidase activity [inference]

positive regulation of peptidase activity [inference]

positive regulation of endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity [inference]

activation of cysteine-type endopeptidase activity

regulation of endopeptidase activity [inference]

positive regulation of endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity [inference]

activation of cysteine-type endopeptidase activity

regulation of cysteine-type endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity [inference]

activation of cysteine-type endopeptidase activity

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
membrane	HDA	19946888
neuron projection	IBA
nucleus	IEA
synapse	IBA IDA	11438699
SCAR complex	IDA	17101133 26428302

GO Hierarchy

cellular component

protein-containing complex [inference]

SCAR complex

cellular anatomical entity [inference]

cell junction [inference]

synapse

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

nucleus

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

perinuclear region of cytoplasm

Displaying **all 3** entries
GO Term	Evidence Code	PMID
protein binding	IPI	11438699 15048733 24658146
small GTPase binding	IEA
RNA 7-methylguanosine cap binding	IBA

GO Hierarchy

molecular function

binding [inference]

protein binding

enzyme binding [inference]

GTPase binding [inference]

small GTPase binding

organic cyclic compound binding [inference]

nucleic acid binding [inference]

RNA binding [inference]

RNA cap binding [inference]

RNA 7-methylguanosine cap binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

cytoplasmic fmr1-interacting protein

Functional Category

E: Amino acid transport and metabolism
G: Carbohydrate transport and metabolism
T: Signal transduction mechanisms

Displaying **all 3** entries
Gene Ontology
RNA 7-methylguanosine cap binding
cell projection assembly
regulation of actin filament polymerization

Displaying **all 2** entries
InterPro
CYRIA/CYRIB, Rac1 binding domain
Cytoplasmic FMR1-interacting

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:0060393	chromosome 15q11.2 deletion syndrome	Alliance of Genome Resources
DOID:0080430	developmental and epileptic encephalopathy 65	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 77 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Drosophila melanogaster	41861		FB:FBgn0038320
Mus musculus	76884		MGI:1924134	MOUSE04270
Caenorhabditis elegans	176885		WB:WBGene00001579
Rattus norvegicus	303073		RGD:1305048	RATNO02411
Xenopus laevis	443897		Xenbase:XB-GENE-922706
Pan troglodytes	462221	9598_0:0016f0		PANTR36691
Canis lupus familiaris	479317			CANLF14871
Bos taurus	518833			BOVIN33829
Macaca mulatta	714984			MACMU39680
Danio rerio	100002872		ZFIN:ZDB-GENE-080724-2	DANRE07872

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Last updated: December 9, 2024