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cytoplasmic FMR1 interacting protein 2

Summary

Gene Symbol

CYFIP2

Organism

Homo sapiens (human)

External Links

NCBI Gene

26999

PubChem

26999

Alliance of Genome Resources

HGNC:13760

Annotation

Keyword

Acetylation
Alternative splicing
Apoptosis
Cell adhesion
Cytoplasm
Disease variant
Epilepsy
Nucleus
Proteomics identification
RNA editing
Reference proteome
Synaptosome

Proteins

Displaying **all 3** entries
UniProt	Protein Name
E7EVJ5
B7Z8N7
Q96F07	p53-inducible protein 121

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 11 in total

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2

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GO Term	Evidence Code	PMID
cell-cell adhesion	IDA	15048733
cell morphogenesis	IBA
dendrite extension	IEA
positive regulation of proteolysis	IDA	18387192
apoptotic process	IBA IDA	10449408

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

protein processing [inference]

zymogen activation [inference]

activation of cysteine-type endopeptidase activity

protein maturation [inference]

protein processing [inference]

zymogen activation [inference]

activation of cysteine-type endopeptidase activity

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

protein processing [inference]

zymogen activation [inference]

activation of cysteine-type endopeptidase activity

protein maturation [inference]

protein processing [inference]

zymogen activation [inference]

activation of cysteine-type endopeptidase activity

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

protein processing [inference]

zymogen activation [inference]

activation of cysteine-type endopeptidase activity

protein maturation [inference]

protein processing [inference]

zymogen activation [inference]

activation of cysteine-type endopeptidase activity

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

protein processing [inference]

zymogen activation [inference]

activation of cysteine-type endopeptidase activity

protein maturation [inference]

protein processing [inference]

zymogen activation [inference]

activation of cysteine-type endopeptidase activity

cellular process [inference]

cell adhesion [inference]

cell-cell adhesion

cell death [inference]

programmed cell death [inference]

apoptotic process

cell growth [inference]

developmental cell growth [inference]

neuron projection extension [inference]

dendrite extension

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

cell projection assembly

cell projection organization [inference]

cell projection assembly

plasma membrane bounded cell projection organization [inference]

neuron projection development [inference]

neuron projection guidance [inference]

axon guidance

regulation of cellular component size [inference]

regulation of actin filament length [inference]

regulation of actin polymerization or depolymerization [inference]

regulation of actin filament polymerization

developmental process [inference]

anatomical structure morphogenesis [inference]

cell morphogenesis

growth [inference]

cell growth [inference]

developmental cell growth [inference]

neuron projection extension [inference]

dendrite extension

developmental growth [inference]

developmental cell growth [inference]

neuron projection extension [inference]

dendrite extension

developmental growth involved in morphogenesis [inference]

neuron projection extension [inference]

dendrite extension

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

positive regulation of metabolic process [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of proteolysis

positive regulation of peptidase activity [inference]

positive regulation of endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity [inference]

activation of cysteine-type endopeptidase activity

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of proteolysis

positive regulation of peptidase activity [inference]

positive regulation of endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity [inference]

activation of cysteine-type endopeptidase activity

regulation of nitrogen compound metabolic process [inference]

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of proteolysis

positive regulation of peptidase activity [inference]

positive regulation of endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity [inference]

activation of cysteine-type endopeptidase activity

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

positive regulation of proteolysis

positive regulation of peptidase activity [inference]

positive regulation of endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity [inference]

activation of cysteine-type endopeptidase activity

regulation of peptidase activity [inference]

positive regulation of peptidase activity [inference]

positive regulation of endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity [inference]

activation of cysteine-type endopeptidase activity

regulation of endopeptidase activity [inference]

positive regulation of endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity [inference]

activation of cysteine-type endopeptidase activity

regulation of cysteine-type endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity [inference]

activation of cysteine-type endopeptidase activity

positive regulation of protein metabolic process [inference]

positive regulation of proteolysis

positive regulation of peptidase activity [inference]

positive regulation of endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity [inference]

activation of cysteine-type endopeptidase activity

regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of proteolysis

positive regulation of peptidase activity [inference]

positive regulation of endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity [inference]

activation of cysteine-type endopeptidase activity

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

positive regulation of proteolysis

positive regulation of peptidase activity [inference]

positive regulation of endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity [inference]

activation of cysteine-type endopeptidase activity

regulation of peptidase activity [inference]

positive regulation of peptidase activity [inference]

positive regulation of endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity [inference]

activation of cysteine-type endopeptidase activity

regulation of endopeptidase activity [inference]

positive regulation of endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity [inference]

activation of cysteine-type endopeptidase activity

regulation of cysteine-type endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity [inference]

activation of cysteine-type endopeptidase activity

positive regulation of protein metabolic process [inference]

positive regulation of proteolysis

positive regulation of peptidase activity [inference]

positive regulation of endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity [inference]

activation of cysteine-type endopeptidase activity

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

positive regulation of proteolysis

positive regulation of peptidase activity [inference]

positive regulation of endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity [inference]

activation of cysteine-type endopeptidase activity

regulation of peptidase activity [inference]

positive regulation of peptidase activity [inference]

positive regulation of endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity [inference]

activation of cysteine-type endopeptidase activity

regulation of endopeptidase activity [inference]

positive regulation of endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity [inference]

activation of cysteine-type endopeptidase activity

regulation of cysteine-type endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity [inference]

activation of cysteine-type endopeptidase activity

positive regulation of protein metabolic process [inference]

positive regulation of proteolysis

positive regulation of peptidase activity [inference]

positive regulation of endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity [inference]

activation of cysteine-type endopeptidase activity

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of neurotrophin TRK receptor signaling pathway

regulation of neurotrophin TRK receptor signaling pathway [inference]

positive regulation of neurotrophin TRK receptor signaling pathway

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of neurotrophin TRK receptor signaling pathway

positive regulation of biological process [inference]

positive regulation of metabolic process [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of proteolysis

positive regulation of peptidase activity [inference]

positive regulation of endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity [inference]

activation of cysteine-type endopeptidase activity

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of proteolysis

positive regulation of peptidase activity [inference]

positive regulation of endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity [inference]

activation of cysteine-type endopeptidase activity

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of neurotrophin TRK receptor signaling pathway

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of neurotrophin TRK receptor signaling pathway

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of neurotrophin TRK receptor signaling pathway

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of neurotrophin TRK receptor signaling pathway

regulation of neurotrophin TRK receptor signaling pathway [inference]

positive regulation of neurotrophin TRK receptor signaling pathway

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of neurotrophin TRK receptor signaling pathway

regulation of cellular response to growth factor stimulus [inference]

regulation of neurotrophin TRK receptor signaling pathway [inference]

positive regulation of neurotrophin TRK receptor signaling pathway

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of neurotrophin TRK receptor signaling pathway

regulation of neurotrophin TRK receptor signaling pathway [inference]

positive regulation of neurotrophin TRK receptor signaling pathway

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of neurotrophin TRK receptor signaling pathway

regulation of actin filament-based process [inference]

regulation of actin cytoskeleton organization [inference]

regulation of actin filament length [inference]

regulation of actin polymerization or depolymerization [inference]

regulation of actin filament polymerization

regulation of actin filament organization [inference]

regulation of actin polymerization or depolymerization [inference]

regulation of actin filament polymerization

regulation of cellular component biogenesis [inference]

regulation of protein-containing complex assembly [inference]

regulation of protein polymerization [inference]

regulation of actin filament polymerization

regulation of cell junction assembly [inference]

regulation of synapse assembly [inference]

regulation of postsynapse assembly

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of neurotrophin TRK receptor signaling pathway

regulation of cellular component organization [inference]

regulation of organelle organization [inference]

regulation of cytoskeleton organization [inference]

regulation of actin cytoskeleton organization [inference]

regulation of actin filament length [inference]

regulation of actin polymerization or depolymerization [inference]

regulation of actin filament polymerization

regulation of actin filament organization [inference]

regulation of actin polymerization or depolymerization [inference]

regulation of actin filament polymerization

regulation of protein-containing complex assembly [inference]

regulation of protein polymerization [inference]

regulation of actin filament polymerization

regulation of synapse organization [inference]

regulation of synapse assembly [inference]

regulation of postsynapse assembly

regulation of postsynapse organization [inference]

regulation of postsynapse assembly

regulation of cell junction assembly [inference]

regulation of synapse assembly [inference]

regulation of postsynapse assembly

regulation of supramolecular fiber organization [inference]

regulation of actin filament organization [inference]

regulation of actin polymerization or depolymerization [inference]

regulation of actin filament polymerization

regulation of biological quality [inference]

regulation of anatomical structure size [inference]

regulation of cellular component size [inference]

regulation of actin filament length [inference]

regulation of actin polymerization or depolymerization [inference]

regulation of actin filament polymerization

regulation of molecular function [inference]

positive regulation of molecular function [inference]

positive regulation of catalytic activity [inference]

positive regulation of hydrolase activity [inference]

positive regulation of peptidase activity [inference]

positive regulation of endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity [inference]

activation of cysteine-type endopeptidase activity

regulation of catalytic activity [inference]

positive regulation of catalytic activity [inference]

positive regulation of hydrolase activity [inference]

positive regulation of peptidase activity [inference]

positive regulation of endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity [inference]

activation of cysteine-type endopeptidase activity

regulation of hydrolase activity [inference]

positive regulation of hydrolase activity [inference]

positive regulation of peptidase activity [inference]

positive regulation of endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity [inference]

activation of cysteine-type endopeptidase activity

regulation of peptidase activity [inference]

positive regulation of peptidase activity [inference]

positive regulation of endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity [inference]

activation of cysteine-type endopeptidase activity

regulation of endopeptidase activity [inference]

positive regulation of endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity [inference]

activation of cysteine-type endopeptidase activity

regulation of cysteine-type endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity [inference]

activation of cysteine-type endopeptidase activity

Displaying entries **6 - 9** of 9 in total

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GO Term	Evidence Code	PMID
cytosol	TAS
perinuclear region of cytoplasm	IDA	10449408
cytoplasm	IDA	11438699
extracellular exosome	HDA	19056867 20458337 23533145

GO Hierarchy

cellular component

protein-containing complex [inference]

SCAR complex

cellular anatomical entity [inference]

cell junction [inference]

synapse

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

nucleus

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

perinuclear region of cytoplasm

Displaying **all 3** entries
GO Term	Evidence Code	PMID
protein binding	IPI	11438699 15048733 24658146
small GTPase binding	IEA
RNA 7-methylguanosine cap binding	IBA

GO Hierarchy

molecular function

binding [inference]

protein binding

enzyme binding [inference]

GTPase binding [inference]

small GTPase binding

organic cyclic compound binding [inference]

nucleic acid binding [inference]

RNA binding [inference]

RNA cap binding [inference]

RNA 7-methylguanosine cap binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

cytoplasmic fmr1-interacting protein

Functional Category

E: Amino acid transport and metabolism
G: Carbohydrate transport and metabolism
T: Signal transduction mechanisms

Displaying **all 3** entries
Gene Ontology
RNA 7-methylguanosine cap binding
cell projection assembly
regulation of actin filament polymerization

Displaying **all 2** entries
InterPro
CYRIA/CYRIB, Rac1 binding domain
Cytoplasmic FMR1-interacting

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:0060393	chromosome 15q11.2 deletion syndrome	Alliance of Genome Resources
DOID:0080430	developmental and epileptic encephalopathy 65	Alliance of Genome Resources

Ortholog

Displaying entries **31 - 40** of 77 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Ovis aries	101113147			SHEEP16980
Gorilla gorilla gorilla	101130377	9595_0:001b62		GORGO34724
Oryzias latipes	101164818			ORYLA01348
Tursiops truncatus	101333892			TURTR08833
Octodon degus	101578615			OCTDE07204
Jaculus jaculus	101602600			JACJA08744
Mustela putorius furo	101681456			MUSPF19729
Anas platyrhynchos platyrhynchos	101800906			ANAPP25411
Ficedula albicollis	101821876			FICAL05943
Melopsittacus undulatus	101868877			MELUD09896

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Last updated: December 9, 2024