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mitogen-activated protein kinase kinase kinase 15

Summary

Gene Symbol

Map3k15

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

270672

PubChem

270672

Alliance of Genome Resources

MGI:2448588

Annotation

Keyword

ATP-binding
Coiled coil
Magnesium
Metal-binding
Reference proteome
Serine/threonine-protein kinase

Proteins

Displaying 1 entry
UniProt	Protein Name
A2AQW0	MAPK/ERK kinase kinase 15

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 4** entries
GO Term	Evidence Code	PMID
JNK cascade	IBA
MAPK cascade	IEA
protein phosphorylation	IEA
p38MAPK cascade	IBA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phosphorylation [inference]

protein phosphorylation

primary metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation

macromolecule modification [inference]

protein modification process [inference]

protein phosphorylation

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation

cellular process [inference]

signal transduction [inference]

intracellular signal transduction [inference]

stress-activated MAPK cascade [inference]

stress-activated protein kinase signaling cascade [inference]

stress-activated MAPK cascade [inference]

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phosphorylation [inference]

protein phosphorylation

cellular response to stimulus [inference]

cellular response to stress [inference]

stress-activated protein kinase signaling cascade [inference]

stress-activated MAPK cascade [inference]

response to stimulus [inference]

response to stress [inference]

cellular response to stress [inference]

stress-activated protein kinase signaling cascade [inference]

stress-activated MAPK cascade [inference]

cellular response to stimulus [inference]

cellular response to stress [inference]

stress-activated protein kinase signaling cascade [inference]

stress-activated MAPK cascade [inference]

biological regulation [inference]

regulation of biological process [inference]

regulation of cellular process [inference]

signal transduction [inference]

intracellular signal transduction [inference]

stress-activated MAPK cascade [inference]

stress-activated protein kinase signaling cascade [inference]

stress-activated MAPK cascade [inference]

Displaying **all 4** entries
GO Term	Evidence Code	PMID
protein serine kinase activity	IEA
metal ion binding	IEA
ATP binding	IEA
MAP kinase kinase kinase activity	IBA ISO ISS

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring phosphorus-containing groups [inference]

kinase activity [inference]

protein kinase activity [inference]

protein serine/threonine kinase activity [inference]

MAP kinase kinase kinase activity

protein serine kinase activity

phosphotransferase activity, alcohol group as acceptor [inference]

protein kinase activity [inference]

protein serine/threonine kinase activity [inference]

MAP kinase kinase kinase activity

protein serine kinase activity

catalytic activity, acting on a protein [inference]

protein kinase activity [inference]

protein serine/threonine kinase activity [inference]

MAP kinase kinase kinase activity

protein serine kinase activity

binding [inference]

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

cation binding [inference]

metal ion binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

mitogen-activated protein kinase kinase kinase 15

Functional Category

H: Coenzyme transport and metabolism
T: Signal transduction mechanisms
X: Mobilome: prophages, transposons

Displaying **all 6** entries
Gene Ontology
ATP binding
cellular response to stress
kinase activity
metal ion binding
nucleotide binding
phosphorylation

Displaying **all 4** entries
InterPro
MAP3K, HisK-N-like globin domain
MAP3K, TRAFs-binding domain
Protein kinase domain
Protein kinase-like domain superfamily

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:670	amphetamine abuse	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of **100** in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Drosophila melanogaster	42366		FB:FBgn0014006
Homo sapiens	389840		HGNC:31689	HUMAN99966
Rattus norvegicus	501558	10116_1:00543d	RGD:1560603	RATNO45419
Bos taurus	529335			BOVIN37379
Macaca mulatta	695958			MACMU48621
Caenorhabditis elegans	24104671		WB:WBGene00003822
Equus caballus	100058434			HORSE44197
Ornithorhynchus anatinus	100083521			ORNAN07110
Xenopus tropicalis	100216453		Xenbase:XB-GENE-1002755
Taeniopygia guttata	100219311			TAEGU11824

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: December 9, 2024