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sorting nexin 5

Summary

Gene Symbol

SNX5

Organism

Homo sapiens (human)

External Links

NCBI Gene

27131

PubChem

27131

Alliance of Genome Resources

HGNC:14969

JoGo

SNX5

TogoVar

SNX5

Annotation

Keyword

3D-structure
Acetylation
Alternative splicing
Cell membrane
Cell projection
Cytoplasm
Cytoplasmic vesicle
Endocytosis
Endosome
Host-virus interaction
Lipid-binding
Phosphoprotein
Protein transport
Proteomics identification
Reference proteome

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q9Y5X3
Q6P5V6

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	PMID
intracellular protein transport	IEA
pinocytosis	IDA	18854019
pinocytosis	IBA
epidermal growth factor catabolic process	IEA
regulation of macroautophagy	NAS	26172538

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein catabolic process [inference]

epidermal growth factor catabolic process

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

epidermal growth factor catabolic process

catabolic process [inference]

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

epidermal growth factor catabolic process

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

epidermal growth factor catabolic process

primary metabolic process [inference]

protein metabolic process [inference]

protein catabolic process [inference]

epidermal growth factor catabolic process

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

epidermal growth factor catabolic process

protein metabolic process [inference]

protein catabolic process [inference]

epidermal growth factor catabolic process

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein catabolic process [inference]

epidermal growth factor catabolic process

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

epidermal growth factor catabolic process

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

epidermal growth factor catabolic process

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

epidermal growth factor catabolic process

cellular process [inference]

vesicle-mediated transport [inference]

endocytosis [inference]

pinocytosis

endosomal transport [inference]

retrograde transport, endosome to Golgi

cellular localization [inference]

intracellular transport [inference]

intracellular protein transport

endosomal transport [inference]

retrograde transport, endosome to Golgi

cytosolic transport [inference]

retrograde transport, endosome to Golgi

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport

establishment of localization [inference]

transport [inference]

vesicle-mediated transport [inference]

endocytosis [inference]

pinocytosis

endosomal transport [inference]

retrograde transport, endosome to Golgi

intracellular transport [inference]

intracellular protein transport

endosomal transport [inference]

retrograde transport, endosome to Golgi

cytosolic transport [inference]

retrograde transport, endosome to Golgi

organic substance transport [inference]

protein transport [inference]

intracellular protein transport

nitrogen compound transport [inference]

protein transport [inference]

intracellular protein transport

import into cell [inference]

endocytosis [inference]

pinocytosis

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport

establishment of localization in cell [inference]

intracellular transport [inference]

intracellular protein transport

endosomal transport [inference]

retrograde transport, endosome to Golgi

cytosolic transport [inference]

retrograde transport, endosome to Golgi

cellular localization [inference]

intracellular transport [inference]

intracellular protein transport

endosomal transport [inference]

retrograde transport, endosome to Golgi

cytosolic transport [inference]

retrograde transport, endosome to Golgi

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of DNA-templated transcription [inference]

positive regulation of transcription, DNA-templated

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

positive regulation of transcription, DNA-templated

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

regulation of catabolic process [inference]

regulation of cellular catabolic process [inference]

regulation of autophagy [inference]

regulation of macroautophagy

regulation of cellular metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

regulation of RNA metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

positive regulation of transcription, DNA-templated

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of DNA-templated transcription [inference]

positive regulation of transcription, DNA-templated

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

positive regulation of transcription, DNA-templated

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

regulation of cellular catabolic process [inference]

regulation of autophagy [inference]

regulation of macroautophagy

regulation of nitrogen compound metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

regulation of RNA metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

positive regulation of transcription, DNA-templated

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of DNA-templated transcription [inference]

positive regulation of transcription, DNA-templated

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

positive regulation of transcription, DNA-templated

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

regulation of RNA metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

positive regulation of transcription, DNA-templated

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

regulation of primary metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

regulation of RNA metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

positive regulation of transcription, DNA-templated

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of insulin receptor signaling pathway

negative regulation of signal transduction [inference]

negative regulation of ERBB signaling pathway [inference]

negative regulation of epidermal growth factor receptor signaling pathway [inference]

epidermal growth factor catabolic process

regulation of insulin receptor signaling pathway [inference]

positive regulation of insulin receptor signaling pathway

regulation of ERBB signaling pathway [inference]

regulation of epidermal growth factor receptor signaling pathway [inference]

negative regulation of epidermal growth factor receptor signaling pathway [inference]

epidermal growth factor catabolic process

negative regulation of ERBB signaling pathway [inference]

negative regulation of epidermal growth factor receptor signaling pathway [inference]

epidermal growth factor catabolic process

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of insulin receptor signaling pathway

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of ERBB signaling pathway [inference]

negative regulation of epidermal growth factor receptor signaling pathway [inference]

epidermal growth factor catabolic process

positive regulation of biological process [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of insulin receptor signaling pathway

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of insulin receptor signaling pathway

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of cellular response to insulin stimulus [inference]

positive regulation of insulin receptor signaling pathway

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of insulin receptor signaling pathway

positive regulation of cellular response to insulin stimulus [inference]

positive regulation of insulin receptor signaling pathway

negative regulation of biological process [inference]

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of ERBB signaling pathway [inference]

negative regulation of epidermal growth factor receptor signaling pathway [inference]

epidermal growth factor catabolic process

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of ERBB signaling pathway [inference]

negative regulation of epidermal growth factor receptor signaling pathway [inference]

epidermal growth factor catabolic process

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of ERBB signaling pathway [inference]

negative regulation of epidermal growth factor receptor signaling pathway [inference]

epidermal growth factor catabolic process

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of insulin receptor signaling pathway

negative regulation of signal transduction [inference]

negative regulation of ERBB signaling pathway [inference]

negative regulation of epidermal growth factor receptor signaling pathway [inference]

epidermal growth factor catabolic process

regulation of insulin receptor signaling pathway [inference]

positive regulation of insulin receptor signaling pathway

regulation of ERBB signaling pathway [inference]

regulation of epidermal growth factor receptor signaling pathway [inference]

negative regulation of epidermal growth factor receptor signaling pathway [inference]

epidermal growth factor catabolic process

negative regulation of ERBB signaling pathway [inference]

negative regulation of epidermal growth factor receptor signaling pathway [inference]

epidermal growth factor catabolic process

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of insulin receptor signaling pathway

positive regulation of cellular response to insulin stimulus [inference]

positive regulation of insulin receptor signaling pathway

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of ERBB signaling pathway [inference]

negative regulation of epidermal growth factor receptor signaling pathway [inference]

epidermal growth factor catabolic process

regulation of cellular response to insulin stimulus [inference]

positive regulation of cellular response to insulin stimulus [inference]

positive regulation of insulin receptor signaling pathway

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of insulin receptor signaling pathway

negative regulation of signal transduction [inference]

negative regulation of ERBB signaling pathway [inference]

negative regulation of epidermal growth factor receptor signaling pathway [inference]

epidermal growth factor catabolic process

regulation of insulin receptor signaling pathway [inference]

positive regulation of insulin receptor signaling pathway

regulation of ERBB signaling pathway [inference]

regulation of epidermal growth factor receptor signaling pathway [inference]

negative regulation of epidermal growth factor receptor signaling pathway [inference]

epidermal growth factor catabolic process

negative regulation of ERBB signaling pathway [inference]

negative regulation of epidermal growth factor receptor signaling pathway [inference]

epidermal growth factor catabolic process

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of insulin receptor signaling pathway

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of ERBB signaling pathway [inference]

negative regulation of epidermal growth factor receptor signaling pathway [inference]

epidermal growth factor catabolic process

regulation of cellular metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

regulation of RNA metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

positive regulation of transcription, DNA-templated

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of DNA-templated transcription [inference]

positive regulation of transcription, DNA-templated

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

positive regulation of transcription, DNA-templated

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

regulation of cellular catabolic process [inference]

regulation of autophagy [inference]

regulation of macroautophagy

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of insulin receptor signaling pathway

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of cellular response to insulin stimulus [inference]

positive regulation of insulin receptor signaling pathway

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of ERBB signaling pathway [inference]

negative regulation of epidermal growth factor receptor signaling pathway [inference]

epidermal growth factor catabolic process

regulation of cellular response to insulin stimulus [inference]

positive regulation of cellular response to insulin stimulus [inference]

positive regulation of insulin receptor signaling pathway

regulation of biological quality [inference]

regulation of blood pressure [inference]

negative regulation of blood pressure

Displaying entries **6 - 10** of 13 in total

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GO Term	Evidence Code	PMID
cytoplasmic side of plasma membrane	IDA	15561769 18854019
retromer complex	IDA	19619496
retromer, tubulation complex	NAS	26220253
intracellular membrane-bounded organelle	IDA
perinuclear region of cytoplasm	IDA	25825816

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

cellular anatomical entity [inference]

cell projection [inference]

plasma membrane bounded cell projection [inference]

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

intracellular membrane-bounded organelle

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

intracellular organelle [inference]

intracellular membrane-bounded organelle

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

side of membrane [inference]

cytoplasmic side of membrane [inference]

cytoplasmic side of plasma membrane

cytoplasmic side of endosome membrane [inference]

cytoplasmic side of early endosome membrane

cluster of actin-based cell projections [inference]

brush border

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
protein binding	IPI	19619496 21988832 23085988 25416956 25588945 28514442 32296183 33961781 35271311
phosphatidylinositol-5-phosphate binding	IEA
D1 dopamine receptor binding	IEA
dynactin binding	IDA	19619496
dynactin binding	IBA