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N-acylethanolamine acid amidase

Summary

Gene Symbol

NAAA

Organism

Homo sapiens (human)

External Links

NCBI Gene

27163

HGNC

736

KEGG Gene ID

hsa:27163

PubChem

27163

Alliance of Genome Resources

HGNC:736

Annotation

Keyword

3D-structure
Alternative splicing
Autocatalytic cleavage
Direct protein sequencing
Disulfide bond
Fatty acid metabolism
Glycoprotein
Hydrolase
Lipid degradation
Lysosome
Membrane
Reference proteome
Signal
Zymogen

Proteins

Displaying 1 entry
UniProt	Protein Name
Q02083	Acid ceramidase-like protein Acylsphingosine deacylase NAAA N-acylsphingosine amidohydrolase-like

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 5** entries
GO Term	Evidence Code	PMID
fatty acid metabolic process	IDA IEA	15655246 30301806
sphingosine metabolic process	IDA	15655246
N-acylphosphatidylethanolamine metabolic process	IDA	22825852
N-acylethanolamine metabolic process	IDA	15655246 30301806
lipid catabolic process	IEA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

amide metabolic process [inference]

N-acylphosphatidylethanolamine metabolic process

organonitrogen compound metabolic process [inference]

sphingolipid metabolic process [inference]

sphingoid metabolic process [inference]

sphingosine metabolic process

amine metabolic process [inference]

biogenic amine metabolic process [inference]

ethanolamine-containing compound metabolic process [inference]

N-acylethanolamine metabolic process

N-acylphosphatidylethanolamine metabolic process

catabolic process [inference]

organic substance catabolic process [inference]

lipid catabolic process

cellular metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylethanolamine metabolic process [inference]

N-acylphosphatidylethanolamine metabolic process

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylethanolamine metabolic process [inference]

N-acylphosphatidylethanolamine metabolic process

cellular lipid metabolic process [inference]

fatty acid metabolic process

membrane lipid metabolic process [inference]

sphingolipid metabolic process [inference]

sphingoid metabolic process [inference]

sphingosine metabolic process

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylethanolamine metabolic process [inference]

N-acylphosphatidylethanolamine metabolic process

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylethanolamine metabolic process [inference]

N-acylphosphatidylethanolamine metabolic process

primary metabolic process [inference]

lipid metabolic process [inference]

lipid catabolic process

cellular lipid metabolic process [inference]

fatty acid metabolic process

membrane lipid metabolic process [inference]

sphingolipid metabolic process [inference]

sphingoid metabolic process [inference]

sphingosine metabolic process

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylethanolamine metabolic process [inference]

N-acylphosphatidylethanolamine metabolic process

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylethanolamine metabolic process [inference]

N-acylphosphatidylethanolamine metabolic process

small molecule metabolic process [inference]

alcohol metabolic process [inference]

polyol metabolic process [inference]

diol metabolic process [inference]

sphingosine metabolic process

primary alcohol metabolic process [inference]

N-acylethanolamine metabolic process

ethanolamine-containing compound metabolic process [inference]

N-acylethanolamine metabolic process

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process

organic substance metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process

lipid metabolic process [inference]

lipid catabolic process

cellular lipid metabolic process [inference]

fatty acid metabolic process

membrane lipid metabolic process [inference]

sphingolipid metabolic process [inference]

sphingoid metabolic process [inference]

sphingosine metabolic process

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylethanolamine metabolic process [inference]

N-acylphosphatidylethanolamine metabolic process

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylethanolamine metabolic process [inference]

N-acylphosphatidylethanolamine metabolic process

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylethanolamine metabolic process [inference]

N-acylphosphatidylethanolamine metabolic process

organonitrogen compound metabolic process [inference]

sphingolipid metabolic process [inference]

sphingoid metabolic process [inference]

sphingosine metabolic process

amine metabolic process [inference]

biogenic amine metabolic process [inference]

ethanolamine-containing compound metabolic process [inference]

N-acylethanolamine metabolic process

N-acylphosphatidylethanolamine metabolic process

organic substance catabolic process [inference]

lipid catabolic process

organic hydroxy compound metabolic process [inference]

alcohol metabolic process [inference]

polyol metabolic process [inference]

diol metabolic process [inference]

sphingosine metabolic process

primary alcohol metabolic process [inference]

N-acylethanolamine metabolic process

ethanolamine-containing compound metabolic process [inference]

N-acylethanolamine metabolic process

cellular process [inference]

cellular metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylethanolamine metabolic process [inference]

N-acylphosphatidylethanolamine metabolic process

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylethanolamine metabolic process [inference]

N-acylphosphatidylethanolamine metabolic process

cellular lipid metabolic process [inference]

fatty acid metabolic process

membrane lipid metabolic process [inference]

sphingolipid metabolic process [inference]

sphingoid metabolic process [inference]

sphingosine metabolic process

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylethanolamine metabolic process [inference]

N-acylphosphatidylethanolamine metabolic process

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylethanolamine metabolic process [inference]

N-acylphosphatidylethanolamine metabolic process

Displaying **all 5** entries
GO Term	Evidence Code	PMID
cytoplasm	IDA	10610717
membrane	IDA	30301806
lysosomal lumen
extracellular exosome	HDA	23533145
lysosome	IDA	15655246

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

vacuolar lumen [inference]

lysosomal lumen

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
N-acylsphingosine amidohydrolase activity	IDA	15655246
fatty acid amide hydrolase activity	IDA	15655246 30301806
N-(long-chain-acyl)ethanolamine deacylase activity	IDA	15655246 22825852
ceramidase activity	IEA
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	IBA IDA	17980170

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds

hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [inference]

binding [inference]

protein binding [inference]

transcription factor binding [inference]

DNA-binding transcription factor binding

Gene Ontology information from NCBI Gene and UniProt.

Human Protein Atlas

ENSG00000138744

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

KEGG BRITE Database

Orthology

K13720

Name

N-(long-chain-acyl)ethanolamine deacylase [EC:3.5.1.60]

References

15655246

Rhea

RHEA:17505

H₂O + N-(long-chain fatty acyl)ethanolamine

a long-chain fatty acid + ethanolamine

Enzyme

3.5.1.60

PMID

4055775

RHEA:20856

H₂O + an N-acylsphing-4-enine

a fatty acid + sphing-4-enine

Enzyme

3.5.1.23

PMID

Disease

Disease Ontology

Displaying entries **31 - 40** of **135** in total

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DO ID	Disease Name	Source
DOID:0110750	type 1 diabetes mellitus 11	DisGeNET
DOID:0110751	type 1 diabetes mellitus 12	DisGeNET
DOID:0110752	type 1 diabetes mellitus 13	DisGeNET
DOID:0110753	type 1 diabetes mellitus 15	DisGeNET
DOID:0110754	type 1 diabetes mellitus 17	DisGeNET
DOID:0110755	type 1 diabetes mellitus 18	DisGeNET
DOID:0110756	type 1 diabetes mellitus 19	DisGeNET
DOID:0110757	type 1 diabetes mellitus 20	DisGeNET
DOID:0110758	type 1 diabetes mellitus 21	DisGeNET
DOID:0110759	type 1 diabetes mellitus 22	DisGeNET

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP003387
Gene Name: N-acylethanolamine acid amidase

Ortholog

Displaying entries **1 - 10** of 68 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Caenorhabditis elegans	190304	WB:WBGene00021917
Ciona intestinalis	100185070		CIOIN01042
Petromyzon marinus	116942793		PETMA07709
Latimeria chalumnae	102360954		LATCH05353
Ictalurus punctatus	108255927		ICTPU17362
Electrophorus electricus	113572914		ELEEL12653
Salmo salar	106585736		SALSA87075
Oryzias latipes	101155680		ORYLA14247
Oreochromis niloticus	100691345		ORENI58539
Sparus aurata	115572096		SPAAU41308

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

All Resources

Other Information

Tools

Search Tools

Summary

External Links

Annotation

KEGG BRITE Database

LIPID MAPS Gene / Proteome Database

International Collaboration

Acknowledgements