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coenzyme Q2, polyprenyltransferase

Summary

Gene Symbol

COQ2

Organism

Homo sapiens (human)

External Links

NCBI Gene

27235

PubChem

27235

Alliance of Genome Resources

HGNC:25223

Annotation

Keyword

Alternative initiation
Alternative splicing
Disease variant
Isoprene biosynthesis
Mitochondrion inner membrane
Neurodegeneration
Parkinsonism
Primary mitochondrial disease
Reference proteome
Transferase
Transit peptide
Transmembrane helix
Ubiquinone biosynthesis

Proteins

Displaying 1 entry
UniProt	Protein Name
Q96H96	4-hydroxybenzoate decaprenyltransferase COQ2 homolog Para-hydroxybenzoate--polyprenyltransferase

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 3** entries
GO Term	Evidence Code	PMID
ubiquinone biosynthetic process	IBA IDA IEA IGI IMP TAS	15153069 16400613 17374725 27493029
glycerol metabolic process	IGI	15153069
isoprenoid biosynthetic process	IEA

GO Hierarchy

biological process

metabolic process [inference]

biosynthetic process [inference]

cellular biosynthetic process [inference]

isoprenoid biosynthetic process

ketone biosynthetic process [inference]

quinone biosynthetic process [inference]

ubiquinone biosynthetic process

small molecule biosynthetic process [inference]

ketone biosynthetic process [inference]

quinone biosynthetic process [inference]

ubiquinone biosynthetic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

isoprenoid biosynthetic process

ketone biosynthetic process [inference]

quinone biosynthetic process [inference]

ubiquinone biosynthetic process

cellular metabolic process [inference]

cellular ketone metabolic process [inference]

ketone biosynthetic process [inference]

quinone biosynthetic process [inference]

ubiquinone biosynthetic process

quinone metabolic process [inference]

ubiquinone metabolic process [inference]

ubiquinone biosynthetic process

quinone biosynthetic process [inference]

ubiquinone biosynthetic process

cellular biosynthetic process [inference]

isoprenoid biosynthetic process

ketone biosynthetic process [inference]

quinone biosynthetic process [inference]

ubiquinone biosynthetic process

cellular lipid metabolic process [inference]

isoprenoid metabolic process [inference]

isoprenoid biosynthetic process

primary metabolic process [inference]

carbohydrate metabolic process [inference]

alditol metabolic process [inference]

glycerol metabolic process

lipid metabolic process [inference]

lipid biosynthetic process [inference]

isoprenoid biosynthetic process

cellular lipid metabolic process [inference]

isoprenoid metabolic process [inference]

isoprenoid biosynthetic process

small molecule metabolic process [inference]

alcohol metabolic process [inference]

polyol metabolic process [inference]

alditol metabolic process [inference]

glycerol metabolic process

cellular ketone metabolic process [inference]

ketone biosynthetic process [inference]

quinone biosynthetic process [inference]

ubiquinone biosynthetic process

quinone metabolic process [inference]

ubiquinone metabolic process [inference]

ubiquinone biosynthetic process

quinone biosynthetic process [inference]

ubiquinone biosynthetic process

small molecule biosynthetic process [inference]

ketone biosynthetic process [inference]

quinone biosynthetic process [inference]

ubiquinone biosynthetic process

organic substance metabolic process [inference]

carbohydrate metabolic process [inference]

alditol metabolic process [inference]

glycerol metabolic process

lipid metabolic process [inference]

lipid biosynthetic process [inference]

isoprenoid biosynthetic process

cellular lipid metabolic process [inference]

isoprenoid metabolic process [inference]

isoprenoid biosynthetic process

cellular ketone metabolic process [inference]

ketone biosynthetic process [inference]

quinone biosynthetic process [inference]

ubiquinone biosynthetic process

quinone metabolic process [inference]

ubiquinone metabolic process [inference]

ubiquinone biosynthetic process

quinone biosynthetic process [inference]

ubiquinone biosynthetic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

isoprenoid biosynthetic process

ketone biosynthetic process [inference]

quinone biosynthetic process [inference]

ubiquinone biosynthetic process

organic hydroxy compound metabolic process [inference]

alcohol metabolic process [inference]

polyol metabolic process [inference]

alditol metabolic process [inference]

glycerol metabolic process

cellular process [inference]

cellular metabolic process [inference]

cellular ketone metabolic process [inference]

ketone biosynthetic process [inference]

quinone biosynthetic process [inference]

ubiquinone biosynthetic process

quinone metabolic process [inference]

ubiquinone metabolic process [inference]

ubiquinone biosynthetic process

quinone biosynthetic process [inference]

ubiquinone biosynthetic process

cellular biosynthetic process [inference]

isoprenoid biosynthetic process

ketone biosynthetic process [inference]

quinone biosynthetic process [inference]

ubiquinone biosynthetic process

cellular lipid metabolic process [inference]

isoprenoid metabolic process [inference]

isoprenoid biosynthetic process

Displaying **all 2** entries
GO Term	Evidence Code	PMID
mitochondrial inner membrane	IBA IDA TAS	27493029
mitochondrion	HTP	34800366

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

organelle membrane [inference]

organelle inner membrane [inference]

mitochondrial inner membrane

mitochondrial membrane [inference]

mitochondrial inner membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

Displaying **all 4** entries
GO Term	Evidence Code	PMID
prenyltransferase activity	IGI	15153069
4-hydroxybenzoate nonaprenyltransferase activity
4-hydroxybenzoate decaprenyltransferase activity
4-hydroxybenzoate octaprenyltransferase activity	IBA IMP	16400613 17374725

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring alkyl or aryl (other than methyl) groups [inference]

prenyltransferase activity

polyprenyltransferase activity [inference]

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

4-hydroxybenzoate

Functional Category

C: Energy production and conversion
G: Carbohydrate transport and metabolism
Q: Secondary metabolites biosynthesis, transport and catabolism

Displaying **all 5** entries
Gene Ontology
4-hydroxybenzoate decaprenyltransferase activity
polyprenyltransferase activity
prenyltransferase activity
transferase activity
ubiquinone biosynthetic process

Displaying **all 5** entries
InterPro
4-hydroxybenzoate polyprenyltransferase-like
Prenyltransferase
UbiA prenyltransferase conserved site
UbiA prenyltransferase family
UbiA prenyltransferase superfamily

Disease

Disease Ontology

Displaying **all 5** entries
DO ID	Disease Name	Source
DOID:0050730	coenzyme Q10 deficiency disease	Alliance of Genome Resources
DOID:0070238	primary coenzyme Q10 deficiency 1	Alliance of Genome Resources
DOID:10603	glucose intolerance	Alliance of Genome Resources
DOID:1184	nephrotic syndrome	Alliance of Genome Resources
DOID:4752	multiple system atrophy	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 86 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Drosophila melanogaster	40988		FB:FBgn0037574
Mus musculus	71883		MGI:1919133	MOUSE47136
Caenorhabditis elegans	175969		WB:WBGene00000762
Pan troglodytes	471210	9598_0:00149f		PANTR33605
Canis lupus familiaris	478457			CANLF13033
Rattus norvegicus	498332		RGD:1306722	RATNO08782
Bos taurus	504633			BOVIN31775
Saccharomyces cerevisiae S288C	855778		SGD:S000005324
Danio rerio	100037331		ZFIN:ZDB-GENE-070410-84	DANRE37330
Equus caballus	100061199			HORSE30938

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Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements