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MIRAGE
glutamate-cysteine ligase catalytic subunit
Summary
- Gene Symbol
-
- GCLC
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- ATP-binding
- Acetylation
- Disease variant
- Glutathione biosynthesis
- Hereditary hemolytic anemia
- Ligase
- Phosphoprotein
- Proteomics identification
- Reference proteome
- Proteins
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| cysteine metabolic process | ||
| glutamate metabolic process | ||
| glutathione biosynthetic process | ||
| glutathione biosynthetic process | ||
| glutathione biosynthetic process |
GO Hierarchy
- response to activity
biological process
metabolic process [inference]
cellular process [inference]
response to stimulus [inference]
response to endogenous stimulus [inference]
response to chemical [inference]
cellular response to stimulus [inference]
biological regulation [inference]
regulation of biological process [inference]
regulation of metabolic process [inference]
negative regulation of metabolic process [inference]
positive regulation of metabolic process [inference]
regulation of catabolic process [inference]
regulation of cellular metabolic process [inference]
regulation of nitrogen compound metabolic process [inference]
regulation of macromolecule metabolic process [inference]
regulation of primary metabolic process [inference]
regulation of signaling [inference]
positive regulation of biological process [inference]
negative regulation of biological process [inference]
regulation of response to stimulus [inference]
regulation of cellular process [inference]
| GO Term | Evidence Code | PMID |
|---|---|---|
| mitochondrion | ||
| cytosol | ||
| glutamate-cysteine ligase complex | ||
| glutamate-cysteine ligase complex |
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| ATP binding | ||
| glutamate binding | ||
| ADP binding | ||
| protein-containing complex binding |
OrthoDB (Group)
- Group level
- Eukaryota
- Group Name
- Glutamate--cysteine ligase
- Functional Category
-
- E: Amino acid transport and metabolism
- J: Translation, ribosomal structure and biogenesis
- T: Signal transduction mechanisms
| Gene Ontology |
|---|
| ATP binding |
| catalytic activity |
| glutamate-cysteine ligase activity |
| glutathione biosynthetic process |
| ligase activity |
| nucleotide binding |
| InterPro |
|---|
| Glutamate-cysteine ligase catalytic subunit |
| Glutamine synthetase/guanido kinase, catalytic domain |
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0111681 | congenital nonspherocytic hemolytic anemia 7 | |
| DOID:1485 | cystic fibrosis | |
| DOID:583 | hemolytic anemia | |
| DOID:5844 | myocardial infarction |
Ortholog
| Species | Gene ID | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|
| 2729 | Xenbase:XB-GENE-1002435 | ||
| 14629 | Xenbase:XB-GENE-1002435 | MOUSE60656 | |
| 25283 | Xenbase:XB-GENE-1002435 | RATNO41217 | |
| 326857 | DANRE05984 | ||
| 512468 | BOVIN18238 | ||
| 609822 | CANLF02862 | ||
| 710508 | MACMU34523 | ||
| 742732 | PANTR38416 | ||
| 100014379 | MONDO14177 | ||
| 100056731 | HORSE19608 |
