GlyCosmos Portal

Annotation

Keyword

3D-structure
Calcium
Cytoplasm
Isomerase
Magnesium
Metal-binding
Prostaglandin biosynthesis
Reference proteome
Transferase

Proteins

Displaying **all 2** entries
UniProt	Protein Name
A0A384P5J0
O60760	GST class-sigma Glutathione S-transferase Glutathione-dependent PGD synthase Glutathione-requiring prostaglandin D synthase Prostaglandin-H2 D-isomerase

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
glutathione metabolic process	IBA
locomotory behavior		10781097
prostaglandin biosynthetic process	IEA
signal transduction		9353279
prostaglandin metabolic process	IDA	12627223

GO Hierarchy

biological process

metabolic process [inference]

biosynthetic process [inference]

cellular biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

icosanoid biosynthetic process [inference]

prostanoid biosynthetic process [inference]

prostaglandin biosynthetic process

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

unsaturated fatty acid biosynthetic process [inference]

prostanoid biosynthetic process [inference]

prostaglandin biosynthetic process

small molecule biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

icosanoid biosynthetic process [inference]

prostanoid biosynthetic process [inference]

prostaglandin biosynthetic process

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

unsaturated fatty acid biosynthetic process [inference]

prostanoid biosynthetic process [inference]

prostaglandin biosynthetic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

unsaturated fatty acid biosynthetic process [inference]

prostanoid biosynthetic process [inference]

prostaglandin biosynthetic process

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

icosanoid biosynthetic process [inference]

prostanoid biosynthetic process [inference]

prostaglandin biosynthetic process

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

unsaturated fatty acid biosynthetic process [inference]

prostanoid biosynthetic process [inference]

prostaglandin biosynthetic process

cellular metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

icosanoid biosynthetic process [inference]

prostanoid biosynthetic process [inference]

prostaglandin biosynthetic process

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

unsaturated fatty acid biosynthetic process [inference]

prostanoid biosynthetic process [inference]

prostaglandin biosynthetic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

icosanoid metabolic process [inference]

prostanoid metabolic process [inference]

prostaglandin metabolic process

prostaglandin biosynthetic process

prostanoid biosynthetic process [inference]

prostaglandin biosynthetic process

icosanoid biosynthetic process [inference]

prostanoid biosynthetic process [inference]

prostaglandin biosynthetic process

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

fatty acid biosynthetic process [inference]

unsaturated fatty acid biosynthetic process [inference]

prostanoid biosynthetic process [inference]

prostaglandin biosynthetic process

unsaturated fatty acid metabolic process [inference]

unsaturated fatty acid biosynthetic process [inference]

prostanoid biosynthetic process [inference]

prostaglandin biosynthetic process

prostanoid metabolic process [inference]

prostaglandin metabolic process

prostaglandin biosynthetic process

prostanoid biosynthetic process [inference]

prostaglandin biosynthetic process

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

unsaturated fatty acid biosynthetic process [inference]

prostanoid biosynthetic process [inference]

prostaglandin biosynthetic process

carboxylic acid biosynthetic process [inference]

icosanoid biosynthetic process [inference]

prostanoid biosynthetic process [inference]

prostaglandin biosynthetic process

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

unsaturated fatty acid biosynthetic process [inference]

prostanoid biosynthetic process [inference]

prostaglandin biosynthetic process

cellular biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

icosanoid biosynthetic process [inference]

prostanoid biosynthetic process [inference]

prostaglandin biosynthetic process

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

unsaturated fatty acid biosynthetic process [inference]

prostanoid biosynthetic process [inference]

prostaglandin biosynthetic process

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

fatty acid biosynthetic process [inference]

unsaturated fatty acid biosynthetic process [inference]

prostanoid biosynthetic process [inference]

prostaglandin biosynthetic process

unsaturated fatty acid metabolic process [inference]

unsaturated fatty acid biosynthetic process [inference]

prostanoid biosynthetic process [inference]

prostaglandin biosynthetic process

prostanoid metabolic process [inference]

prostaglandin metabolic process

prostaglandin biosynthetic process

prostanoid biosynthetic process [inference]

prostaglandin biosynthetic process

primary metabolic process [inference]

lipid metabolic process [inference]

lipid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

unsaturated fatty acid biosynthetic process [inference]

prostanoid biosynthetic process [inference]

prostaglandin biosynthetic process

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

fatty acid biosynthetic process [inference]

unsaturated fatty acid biosynthetic process [inference]

prostanoid biosynthetic process [inference]

prostaglandin biosynthetic process

unsaturated fatty acid metabolic process [inference]

unsaturated fatty acid biosynthetic process [inference]

prostanoid biosynthetic process [inference]

prostaglandin biosynthetic process

prostanoid metabolic process [inference]

prostaglandin metabolic process

prostaglandin biosynthetic process

prostanoid biosynthetic process [inference]

prostaglandin biosynthetic process

small molecule metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

icosanoid biosynthetic process [inference]

prostanoid biosynthetic process [inference]

prostaglandin biosynthetic process

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

unsaturated fatty acid biosynthetic process [inference]

prostanoid biosynthetic process [inference]

prostaglandin biosynthetic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

icosanoid metabolic process [inference]

prostanoid metabolic process [inference]

prostaglandin metabolic process

prostaglandin biosynthetic process

prostanoid biosynthetic process [inference]

prostaglandin biosynthetic process

icosanoid biosynthetic process [inference]

prostanoid biosynthetic process [inference]

prostaglandin biosynthetic process

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

fatty acid biosynthetic process [inference]

unsaturated fatty acid biosynthetic process [inference]

prostanoid biosynthetic process [inference]

prostaglandin biosynthetic process

unsaturated fatty acid metabolic process [inference]

unsaturated fatty acid biosynthetic process [inference]

prostanoid biosynthetic process [inference]

prostaglandin biosynthetic process

prostanoid metabolic process [inference]

prostaglandin metabolic process

prostaglandin biosynthetic process

prostanoid biosynthetic process [inference]

prostaglandin biosynthetic process

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

unsaturated fatty acid biosynthetic process [inference]

prostanoid biosynthetic process [inference]

prostaglandin biosynthetic process

carboxylic acid biosynthetic process [inference]

icosanoid biosynthetic process [inference]

prostanoid biosynthetic process [inference]

prostaglandin biosynthetic process

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

unsaturated fatty acid biosynthetic process [inference]

prostanoid biosynthetic process [inference]

prostaglandin biosynthetic process

small molecule biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

icosanoid biosynthetic process [inference]

prostanoid biosynthetic process [inference]

prostaglandin biosynthetic process

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

unsaturated fatty acid biosynthetic process [inference]

prostanoid biosynthetic process [inference]

prostaglandin biosynthetic process

organic substance metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

icosanoid biosynthetic process [inference]

prostanoid biosynthetic process [inference]

prostaglandin biosynthetic process

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

unsaturated fatty acid biosynthetic process [inference]

prostanoid biosynthetic process [inference]

prostaglandin biosynthetic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

icosanoid metabolic process [inference]

prostanoid metabolic process [inference]

prostaglandin metabolic process

prostaglandin biosynthetic process

prostanoid biosynthetic process [inference]

prostaglandin biosynthetic process

icosanoid biosynthetic process [inference]

prostanoid biosynthetic process [inference]

prostaglandin biosynthetic process

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

fatty acid biosynthetic process [inference]

unsaturated fatty acid biosynthetic process [inference]

prostanoid biosynthetic process [inference]

prostaglandin biosynthetic process

unsaturated fatty acid metabolic process [inference]

unsaturated fatty acid biosynthetic process [inference]

prostanoid biosynthetic process [inference]

prostaglandin biosynthetic process

prostanoid metabolic process [inference]

prostaglandin metabolic process

prostaglandin biosynthetic process

prostanoid biosynthetic process [inference]

prostaglandin biosynthetic process

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

unsaturated fatty acid biosynthetic process [inference]

prostanoid biosynthetic process [inference]

prostaglandin biosynthetic process

carboxylic acid biosynthetic process [inference]

icosanoid biosynthetic process [inference]

prostanoid biosynthetic process [inference]

prostaglandin biosynthetic process

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

unsaturated fatty acid biosynthetic process [inference]

prostanoid biosynthetic process [inference]

prostaglandin biosynthetic process

lipid metabolic process [inference]

lipid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

unsaturated fatty acid biosynthetic process [inference]

prostanoid biosynthetic process [inference]

prostaglandin biosynthetic process

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

fatty acid biosynthetic process [inference]

unsaturated fatty acid biosynthetic process [inference]

prostanoid biosynthetic process [inference]

prostaglandin biosynthetic process

unsaturated fatty acid metabolic process [inference]

unsaturated fatty acid biosynthetic process [inference]

prostanoid biosynthetic process [inference]

prostaglandin biosynthetic process

prostanoid metabolic process [inference]

prostaglandin metabolic process

prostaglandin biosynthetic process

prostanoid biosynthetic process [inference]

prostaglandin biosynthetic process

glutathione metabolic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

unsaturated fatty acid biosynthetic process [inference]

prostanoid biosynthetic process [inference]

prostaglandin biosynthetic process

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

icosanoid biosynthetic process [inference]

prostanoid biosynthetic process [inference]

prostaglandin biosynthetic process

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

unsaturated fatty acid biosynthetic process [inference]

prostanoid biosynthetic process [inference]

prostaglandin biosynthetic process

cellular process [inference]

signal transduction

cellular metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

icosanoid biosynthetic process [inference]

prostanoid biosynthetic process [inference]

prostaglandin biosynthetic process

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

unsaturated fatty acid biosynthetic process [inference]

prostanoid biosynthetic process [inference]

prostaglandin biosynthetic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

icosanoid metabolic process [inference]

prostanoid metabolic process [inference]

prostaglandin metabolic process

prostaglandin biosynthetic process

prostanoid biosynthetic process [inference]

prostaglandin biosynthetic process

icosanoid biosynthetic process [inference]

prostanoid biosynthetic process [inference]

prostaglandin biosynthetic process

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

fatty acid biosynthetic process [inference]

unsaturated fatty acid biosynthetic process [inference]

prostanoid biosynthetic process [inference]

prostaglandin biosynthetic process

unsaturated fatty acid metabolic process [inference]

unsaturated fatty acid biosynthetic process [inference]

prostanoid biosynthetic process [inference]

prostaglandin biosynthetic process

prostanoid metabolic process [inference]

prostaglandin metabolic process

prostaglandin biosynthetic process

prostanoid biosynthetic process [inference]

prostaglandin biosynthetic process

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

unsaturated fatty acid biosynthetic process [inference]

prostanoid biosynthetic process [inference]

prostaglandin biosynthetic process

carboxylic acid biosynthetic process [inference]

icosanoid biosynthetic process [inference]

prostanoid biosynthetic process [inference]

prostaglandin biosynthetic process

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

unsaturated fatty acid biosynthetic process [inference]

prostanoid biosynthetic process [inference]

prostaglandin biosynthetic process

cellular biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

icosanoid biosynthetic process [inference]

prostanoid biosynthetic process [inference]

prostaglandin biosynthetic process

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

unsaturated fatty acid biosynthetic process [inference]

prostanoid biosynthetic process [inference]

prostaglandin biosynthetic process

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

fatty acid biosynthetic process [inference]

unsaturated fatty acid biosynthetic process [inference]

prostanoid biosynthetic process [inference]

prostaglandin biosynthetic process

unsaturated fatty acid metabolic process [inference]

unsaturated fatty acid biosynthetic process [inference]

prostanoid biosynthetic process [inference]

prostaglandin biosynthetic process

prostanoid metabolic process [inference]

prostaglandin metabolic process

prostaglandin biosynthetic process

prostanoid biosynthetic process [inference]

prostaglandin biosynthetic process

multicellular organismal process [inference]

behavior [inference]

locomotory behavior

biological regulation [inference]

regulation of biological process [inference]

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of cell population proliferation [inference]

negative regulation of germ cell proliferation [inference]

negative regulation of male germ cell proliferation

negative regulation of multicellular organismal process [inference]

negative regulation of germ cell proliferation [inference]

negative regulation of male germ cell proliferation

negative regulation of reproductive process [inference]

negative regulation of germ cell proliferation [inference]

negative regulation of male germ cell proliferation

regulation of cellular process [inference]

signal transduction

regulation of cell population proliferation [inference]

negative regulation of cell population proliferation [inference]

negative regulation of germ cell proliferation [inference]

negative regulation of male germ cell proliferation

regulation of germ cell proliferation [inference]

negative regulation of germ cell proliferation [inference]

negative regulation of male germ cell proliferation

regulation of male germ cell proliferation [inference]

negative regulation of male germ cell proliferation

negative regulation of cellular process [inference]

negative regulation of cell population proliferation [inference]

negative regulation of germ cell proliferation [inference]

negative regulation of male germ cell proliferation

regulation of multicellular organismal process [inference]

negative regulation of multicellular organismal process [inference]

negative regulation of germ cell proliferation [inference]

negative regulation of male germ cell proliferation

regulation of germ cell proliferation [inference]

negative regulation of germ cell proliferation [inference]

negative regulation of male germ cell proliferation

regulation of male germ cell proliferation [inference]

negative regulation of male germ cell proliferation

regulation of reproductive process [inference]

regulation of germ cell proliferation [inference]

negative regulation of germ cell proliferation [inference]

negative regulation of male germ cell proliferation

regulation of male germ cell proliferation [inference]

negative regulation of male germ cell proliferation

negative regulation of reproductive process [inference]

negative regulation of germ cell proliferation [inference]

negative regulation of male germ cell proliferation

Displaying **all 4** entries
GO Term	Evidence Code	PMID
intracellular membrane-bounded organelle	IDA
cytosol	IDA TAS
cytoplasm		9353279
nucleoplasm	IDA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle

intracellular organelle [inference]

intracellular membrane-bounded organelle

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
magnesium ion binding	IDA	12627223
protein homodimerization activity	IPI	12627223
calcium ion binding	IDA	12627223
protein binding	IPI	25416956 31515488 32296183
prostaglandin-D synthase activity	IDA	12627223

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring alkyl or aryl (other than methyl) groups [inference]

glutathione transferase activity

isomerase activity [inference]

intramolecular oxidoreductase activity [inference]

prostaglandin-D synthase activity

binding [inference]

protein binding

identical protein binding [inference]

protein homodimerization activity

protein dimerization activity [inference]

protein homodimerization activity

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

Gene Ontology information from NCBI Gene and UniProt.

Human Protein Atlas

ENSG00000163106

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

KEGG BRITE Database

Orthology

K04097

Name

prostaglandin-H2 D-isomerase / glutathione transferase [EC:5.3.99.2 2.5.1.18]

References

Rhea

RHEA:10600

prostaglandin H₂

prostaglandin D₂

Enzyme

5.3.99.2

PMID

RHEA:51220

1-chloro-2,4-dinitrobenzene + glutathione

2,4-dinitrophenyl-S-glutathione + H⁺ + chloride

Enzyme

2.5.1.18

PMID

RHEA:16437

RX + glutathione

H⁺ + a halide anion + an S-substituted glutathione

Enzyme

2.5.1.18

PMID

Disease

Disease Ontology

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DO ID	Disease Name	Source
DOID:5517	stomach carcinoma	DisGeNET DisGeNET
DOID:552	pneumonia	DisGeNET DisGeNET
DOID:5520	head and neck squamous cell carcinoma	DisGeNET DisGeNET
DOID:5556	testicular malignant germ cell cancer	DisGeNET
DOID:5557	testicular germ cell cancer	DisGeNET DisGeNET
DOID:5603	T-cell acute lymphoblastic leukemia	DisGeNET
DOID:5604	adult acute lymphocytic leukemia	DisGeNET
DOID:5672	large intestine cancer	DisGeNET DisGeNET DisGeNET DisGeNET
DOID:5675	cribriform carcinoma	DisGeNET
DOID:57	aortic valve insufficiency	DisGeNET

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP001538
Gene Name: hematopoietic prostaglandin D synthase

Ortholog

Displaying entries **1 - 10** of 81 in total

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Species	Gene ID	Alliance of Genome Resources
Caenorhabditis elegans	173841	WB:WBGene00001754
Caenorhabditis elegans	173842	WB:WBGene00001755
Caenorhabditis elegans	175008	WB:WBGene00001768
Caenorhabditis elegans	175166	WB:WBGene00001775
Caenorhabditis elegans	177883	WB:WBGene00001751
Caenorhabditis elegans	178771	WB:WBGene00001781
Caenorhabditis elegans	184364	WB:WBGene00001756
Caenorhabditis elegans	185299	WB:WBGene00001786
Caenorhabditis elegans	187537	WB:WBGene00001753
Caenorhabditis elegans	187615	WB:WBGene00001757

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

All Resources

Other Information

Tools

Search Tools

Summary

External Links

Annotation

KEGG BRITE Database

LIPID MAPS Gene / Proteome Database

International Collaboration

Acknowledgements