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angiopoietin like 3

Summary

Gene Symbol

ANGPTL3

Organism

Homo sapiens (human)

External Links

NCBI Gene

27329

PubChem

27329

Alliance of Genome Resources

HGNC:491

Annotation

Keyword

3D-structure
Angiogenesis
Cell adhesion
Cell projection
Coiled coil
Direct protein sequencing
Disulfide bond
Glycoprotein
Heparin-binding
Lipid metabolism
Reference proteome
Secreted
Signal

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9Y5C1	Angiopoietin-5 Angiopoietin-like protein 3

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 27 in total

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GO Term	Evidence Code	PMID
angiogenesis	IEA
glycerol metabolic process	IDA	12565906
fatty acid metabolic process	IDA	12565906
phospholipid metabolic process	IDA	17110602
cell-matrix adhesion	IPI	11877390

GO Hierarchy

biological process

metabolic process [inference]

catabolic process [inference]

cellular catabolic process [inference]

cellular lipid catabolic process [inference]

phospholipid catabolic process

organic substance catabolic process [inference]

lipid catabolic process [inference]

cellular lipid catabolic process [inference]

phospholipid catabolic process

organophosphate catabolic process [inference]

phospholipid catabolic process

cellular metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process

phospholipid catabolic process

organophosphate metabolic process [inference]

phospholipid metabolic process

phospholipid catabolic process

organophosphate catabolic process [inference]

phospholipid catabolic process

cellular catabolic process [inference]

cellular lipid catabolic process [inference]

phospholipid catabolic process

cellular lipid metabolic process [inference]

fatty acid metabolic process

phospholipid metabolic process

phospholipid catabolic process

cellular lipid catabolic process [inference]

phospholipid catabolic process

primary metabolic process [inference]

carbohydrate metabolic process [inference]

alditol metabolic process [inference]

glycerol metabolic process

lipid metabolic process [inference]

steroid metabolic process [inference]

sterol metabolic process [inference]

cholesterol metabolic process

lipid catabolic process [inference]

cellular lipid catabolic process [inference]

phospholipid catabolic process

cellular lipid metabolic process [inference]

fatty acid metabolic process

phospholipid metabolic process

phospholipid catabolic process

cellular lipid catabolic process [inference]

phospholipid catabolic process

small molecule metabolic process [inference]

alcohol metabolic process [inference]

polyol metabolic process [inference]

alditol metabolic process [inference]

glycerol metabolic process

secondary alcohol metabolic process [inference]

cholesterol metabolic process

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process

organic substance metabolic process [inference]

carbohydrate metabolic process [inference]

alditol metabolic process [inference]

glycerol metabolic process

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process

lipid metabolic process [inference]

steroid metabolic process [inference]

sterol metabolic process [inference]

cholesterol metabolic process

lipid catabolic process [inference]

cellular lipid catabolic process [inference]

phospholipid catabolic process

cellular lipid metabolic process [inference]

fatty acid metabolic process

phospholipid metabolic process

phospholipid catabolic process

cellular lipid catabolic process [inference]

phospholipid catabolic process

organophosphate metabolic process [inference]

phospholipid metabolic process

phospholipid catabolic process

organophosphate catabolic process [inference]

phospholipid catabolic process

organic cyclic compound metabolic process [inference]

steroid metabolic process [inference]

sterol metabolic process [inference]

cholesterol metabolic process

organic substance catabolic process [inference]

lipid catabolic process [inference]

cellular lipid catabolic process [inference]

phospholipid catabolic process

organophosphate catabolic process [inference]

phospholipid catabolic process

organic hydroxy compound metabolic process [inference]

alcohol metabolic process [inference]

polyol metabolic process [inference]

alditol metabolic process [inference]

glycerol metabolic process

secondary alcohol metabolic process [inference]

cholesterol metabolic process

sterol metabolic process [inference]

cholesterol metabolic process

cellular process [inference]

cell adhesion [inference]

cell-substrate adhesion [inference]

cell-matrix adhesion

signal transduction

cell surface receptor signaling pathway [inference]

integrin-mediated signaling pathway

cellular metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process

phospholipid catabolic process

organophosphate metabolic process [inference]

phospholipid metabolic process

phospholipid catabolic process

organophosphate catabolic process [inference]

phospholipid catabolic process

cellular catabolic process [inference]

cellular lipid catabolic process [inference]

phospholipid catabolic process

cellular lipid metabolic process [inference]

fatty acid metabolic process

phospholipid metabolic process

phospholipid catabolic process

cellular lipid catabolic process [inference]

phospholipid catabolic process

developmental process [inference]

anatomical structure morphogenesis [inference]

tube morphogenesis [inference]

blood vessel morphogenesis [inference]

artery morphogenesis

anatomical structure formation involved in morphogenesis [inference]

angiogenesis

homeostatic process [inference]

chemical homeostasis [inference]

lipid homeostasis

acylglycerol homeostasis

triglyceride homeostasis

phospholipid homeostasis

sterol homeostasis [inference]

cholesterol homeostasis

response to stimulus [inference]

response to endogenous stimulus [inference]

response to hormone

response to chemical [inference]

response to organic substance [inference]

response to hormone

localization [inference]

maintenance of location [inference]

lipid storage

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

positive regulation of metabolic process [inference]

positive regulation of catabolic process [inference]

positive regulation of lipid catabolic process

positive regulation of lipid metabolic process [inference]

positive regulation of lipid catabolic process

regulation of catabolic process [inference]

positive regulation of catabolic process [inference]

positive regulation of lipid catabolic process

regulation of lipid catabolic process [inference]

positive regulation of lipid catabolic process

regulation of primary metabolic process [inference]

regulation of lipid metabolic process [inference]

positive regulation of lipid metabolic process [inference]

positive regulation of lipid catabolic process

regulation of lipid catabolic process [inference]

positive regulation of lipid catabolic process

regulation of locomotion [inference]

positive regulation of locomotion [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration

regulation of cell motility [inference]

regulation of cell migration [inference]

positive regulation of cell migration

positive regulation of cell motility [inference]

positive regulation of cell migration

positive regulation of biological process [inference]

positive regulation of metabolic process [inference]

positive regulation of catabolic process [inference]

positive regulation of lipid catabolic process

positive regulation of lipid metabolic process [inference]

positive regulation of lipid catabolic process

positive regulation of locomotion [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration

positive regulation of cellular process [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration

positive regulation of developmental process [inference]

positive regulation of vasculature development [inference]

positive regulation of angiogenesis

positive regulation of multicellular organismal process [inference]

positive regulation of vasculature development [inference]

positive regulation of angiogenesis

regulation of developmental process [inference]

regulation of anatomical structure morphogenesis [inference]

regulation of angiogenesis [inference]

positive regulation of angiogenesis

positive regulation of developmental process [inference]

positive regulation of vasculature development [inference]

positive regulation of angiogenesis

regulation of multicellular organismal development [inference]

regulation of vasculature development [inference]

regulation of angiogenesis [inference]

positive regulation of angiogenesis

positive regulation of vasculature development [inference]

positive regulation of angiogenesis

regulation of cellular process [inference]

signal transduction

cell surface receptor signaling pathway [inference]

integrin-mediated signaling pathway

positive regulation of cellular process [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration

regulation of cell motility [inference]

regulation of cell migration [inference]

positive regulation of cell migration

positive regulation of cell motility [inference]

positive regulation of cell migration

regulation of multicellular organismal process [inference]

positive regulation of multicellular organismal process [inference]

positive regulation of vasculature development [inference]

positive regulation of angiogenesis

regulation of multicellular organismal development [inference]

regulation of vasculature development [inference]

regulation of angiogenesis [inference]

positive regulation of angiogenesis

positive regulation of vasculature development [inference]

positive regulation of angiogenesis

regulation of molecular function [inference]

negative regulation of molecular function [inference]

negative regulation of catalytic activity [inference]

negative regulation of hydrolase activity [inference]

negative regulation of lipase activity [inference]

regulation of catalytic activity [inference]

negative regulation of catalytic activity [inference]

negative regulation of hydrolase activity [inference]

negative regulation of lipase activity [inference]

regulation of hydrolase activity [inference]

negative regulation of hydrolase activity [inference]

negative regulation of lipase activity [inference]

regulation of lipase activity [inference]

regulation of phospholipase activity [inference]

negative regulation of phospholipase activity

regulation of lipoprotein lipase activity [inference]

negative regulation of lipoprotein lipase activity

negative regulation of lipase activity [inference]

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GO Term	Evidence Code	PMID
extracellular region	TAS
extracellular space	IDA	17110602
extracellular space	IBA
early endosome	IEA
Golgi apparatus	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

external encapsulating structure [inference]

extracellular matrix [inference]

collagen-containing extracellular matrix

cell projection [inference]

plasma membrane bounded cell projection [inference]

lamellipodium

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

early endosome

intracellular membrane-bounded organelle [inference]

Golgi apparatus

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

early endosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

Golgi apparatus

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

early endosome

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GO Term	Evidence Code	PMID
enzyme inhibitor activity	ISS
phospholipase inhibitor activity	IDA	17110602
phospholipase inhibitor activity	IBA
integrin binding	IPI	11877390
growth factor activity	IDA	11877390

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

signaling receptor binding [inference]

integrin binding

receptor ligand activity [inference]

growth factor activity

cell adhesion molecule binding [inference]

integrin binding

protein-containing complex binding [inference]

integrin binding

carbohydrate derivative binding [inference]

glycosaminoglycan binding [inference]

heparin binding

sulfur compound binding [inference]

heparin binding

molecular function regulator activity [inference]

enzyme regulator activity [inference]

enzyme inhibitor activity

lipase inhibitor activity [inference]

phospholipase inhibitor activity

signaling receptor regulator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity [inference]

growth factor activity

molecular function activator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity [inference]

growth factor activity

molecular function inhibitor activity [inference]

enzyme inhibitor activity

lipase inhibitor activity [inference]

phospholipase inhibitor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Angiopoietin-related protein 3

Functional Category

D: Cell cycle control, cell division, chromosome partitioning
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 3** entries
Gene Ontology
phospholipid catabolic process
phospholipid homeostasis
triglyceride homeostasis

Displaying **all 3** entries
InterPro
Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain
Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1
Fibrinogen-like, C-terminal

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0111061	familial hypobetalipoproteinemia 2	Alliance of Genome Resources

Ortholog

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Drosophila melanogaster	284	FB:FBgn0003326
Drosophila melanogaster	285	FB:FBgn0003326
Caenorhabditis elegans	7143	WB:WBGene00017013
Xenopus tropicalis	27329	Xenbase:XB-GENE-6258790
Mus musculus	30924	Xenbase:XB-GENE-6258790	MOUSE41599
Xenopus tropicalis	36411	Xenbase:XB-GENE-6258790
Drosophila melanogaster	51129	FB:FBgn0038365
Drosophila melanogaster	51378	FB:FBgn0003326
Drosophila melanogaster	57875	FB:FBgn0003326
Drosophila melanogaster	70726	FB:FBgn0003326

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OrthoDB (Group)

International Collaboration

Acknowledgements