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glycine receptor beta

Summary

Gene Symbol

GLRB

Organism

Homo sapiens (human)

External Links

NCBI Gene

2743

PubChem

2743

Alliance of Genome Resources

HGNC:4329

Annotation

Keyword

3D-structure
Alternative splicing
Cell membrane
Cell projection
Chloride channel
Cytoplasm
Disease variant
Disulfide bond
Glycoprotein
Ligand-gated ion channel
Phosphoprotein
Postsynaptic cell membrane
Proteomics identification
Receptor
Reference proteome
Signal
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
P48167	Glycine receptor 58 kDa subunit

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 15 in total

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GO Term	Evidence Code	PMID
startle response	IMP	11929858
monoatomic ion transport	IDA	8717357
ion transport	IDA	8717357
neuropeptide signaling pathway	IDA	8717357
chemical synaptic transmission	IMP	11929858

GO Hierarchy

biological process

cellular process [inference]

cell communication [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission

synaptic transmission, glycinergic

signal transduction [inference]

G protein-coupled receptor signaling pathway [inference]

neuropeptide signaling pathway

cellular localization [inference]

localization within membrane [inference]

protein localization to membrane [inference]

receptor clustering [inference]

neurotransmitter-gated ion channel clustering [inference]

gamma-aminobutyric acid receptor clustering

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to membrane [inference]

receptor clustering [inference]

neurotransmitter-gated ion channel clustering [inference]

gamma-aminobutyric acid receptor clustering

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic anion transmembrane transport [inference]

chloride transmembrane transport

inorganic ion transmembrane transport [inference]

inorganic anion transmembrane transport [inference]

chloride transmembrane transport

reproductive process [inference]

acrosome reaction

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

sensory perception [inference]

sensory perception of light stimulus [inference]

visual perception

neuromuscular process [inference]

startle response

behavior [inference]

locomotory behavior [inference]

adult locomotory behavior [inference]

adult walking behavior

walking behavior [inference]

adult walking behavior

adult behavior [inference]

adult locomotory behavior [inference]

adult walking behavior

developmental process [inference]

anatomical structure development [inference]

system development [inference]

nervous system development

response to stimulus [inference]

response to external stimulus [inference]

startle response

reflex [inference]

righting reflex

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to membrane [inference]

receptor clustering [inference]

neurotransmitter-gated ion channel clustering [inference]

gamma-aminobutyric acid receptor clustering

establishment of localization [inference]

transport [inference]

monoatomic ion transport

monoatomic anion transport [inference]

chloride transport [inference]

chloride transmembrane transport

monoatomic anion transmembrane transport [inference]

chloride transmembrane transport

monoatomic ion transmembrane transport [inference]

monoatomic anion transmembrane transport [inference]

chloride transmembrane transport

inorganic anion transport [inference]

chloride transport [inference]

chloride transmembrane transport

inorganic anion transmembrane transport [inference]

chloride transmembrane transport

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic anion transmembrane transport [inference]

chloride transmembrane transport

inorganic ion transmembrane transport [inference]

inorganic anion transmembrane transport [inference]

chloride transmembrane transport

cellular localization [inference]

localization within membrane [inference]

protein localization to membrane [inference]

receptor clustering [inference]

neurotransmitter-gated ion channel clustering [inference]

gamma-aminobutyric acid receptor clustering

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to membrane [inference]

receptor clustering [inference]

neurotransmitter-gated ion channel clustering [inference]

gamma-aminobutyric acid receptor clustering

biological regulation [inference]

regulation of biological process [inference]

signaling [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission

synaptic transmission, glycinergic

regulation of cellular process [inference]

signal transduction [inference]

G protein-coupled receptor signaling pathway [inference]

neuropeptide signaling pathway

regulation of biological quality [inference]

regulation of membrane potential [inference]

regulation of postsynaptic membrane potential [inference]

excitatory postsynaptic potential

Displaying entries **1 - 5** of 13 in total

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GO Term	Evidence Code	PMID
cytoplasm	IEA
plasma membrane	TAS
plasma membrane	IDA	8717357
plasma membrane	IMP	11929858
glycine-gated chloride channel complex	IDA	11929858

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

plasma membrane protein complex [inference]

glycine-gated chloride channel complex

transmembrane transporter complex

monoatomic ion channel complex [inference]

chloride channel complex [inference]

glycine-gated chloride channel complex

transporter complex [inference]

transmembrane transporter complex

monoatomic ion channel complex [inference]

chloride channel complex [inference]

glycine-gated chloride channel complex

cellular anatomical entity [inference]

cytoplasm

membrane [inference]

plasma membrane

plasma membrane region [inference]

synaptic membrane [inference]

postsynaptic membrane

cell junction [inference]

synapse

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection

dendrite

organelle [inference]

postsynaptic specialization

Displaying entries **6 - 10** of 10 in total

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GO Term	Evidence Code	PMID
extracellularly glycine-gated ion channel activity	IMP	11929858
extracellularly glycine-gated chloride channel activity	IDA	8717357
neurotransmitter receptor activity
protein-containing complex binding	IEA
transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	IEA

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity [inference]

monoatomic ion transmembrane transporter activity [inference]

monoatomic ion channel activity [inference]

monoatomic anion channel activity [inference]

chloride channel activity

extracellularly glycine-gated chloride channel activity

ligand-gated monoatomic anion channel activity [inference]

extracellularly glycine-gated chloride channel activity

ligand-gated monoatomic ion channel activity [inference]

extracellular ligand-gated monoatomic ion channel activity [inference]

excitatory extracellular ligand-gated monoatomic ion channel activity

extracellularly glycine-gated ion channel activity

extracellularly glycine-gated chloride channel activity

inhibitory extracellular ligand-gated monoatomic ion channel activity [inference]

extracellularly glycine-gated chloride channel activity

transmitter-gated monoatomic ion channel activity [inference]

transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential

ligand-gated monoatomic anion channel activity [inference]

extracellularly glycine-gated chloride channel activity

monoatomic anion transmembrane transporter activity [inference]

monoatomic anion channel activity [inference]

chloride channel activity

extracellularly glycine-gated chloride channel activity

ligand-gated monoatomic anion channel activity [inference]

extracellularly glycine-gated chloride channel activity

chloride transmembrane transporter activity [inference]

chloride channel activity

extracellularly glycine-gated chloride channel activity

inorganic molecular entity transmembrane transporter activity [inference]

inorganic anion transmembrane transporter activity [inference]

chloride transmembrane transporter activity [inference]

chloride channel activity

extracellularly glycine-gated chloride channel activity

passive transmembrane transporter activity [inference]

channel activity [inference]

monoatomic ion channel activity [inference]

monoatomic anion channel activity [inference]

chloride channel activity

extracellularly glycine-gated chloride channel activity

ligand-gated monoatomic anion channel activity [inference]

extracellularly glycine-gated chloride channel activity

ligand-gated monoatomic ion channel activity [inference]

extracellular ligand-gated monoatomic ion channel activity [inference]

excitatory extracellular ligand-gated monoatomic ion channel activity

extracellularly glycine-gated ion channel activity

extracellularly glycine-gated chloride channel activity

inhibitory extracellular ligand-gated monoatomic ion channel activity [inference]

extracellularly glycine-gated chloride channel activity

transmitter-gated monoatomic ion channel activity [inference]

transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential

ligand-gated monoatomic anion channel activity [inference]

extracellularly glycine-gated chloride channel activity

gated channel activity [inference]

ligand-gated channel activity [inference]

ligand-gated monoatomic ion channel activity [inference]

extracellular ligand-gated monoatomic ion channel activity [inference]

excitatory extracellular ligand-gated monoatomic ion channel activity

extracellularly glycine-gated ion channel activity

extracellularly glycine-gated chloride channel activity

inhibitory extracellular ligand-gated monoatomic ion channel activity [inference]

extracellularly glycine-gated chloride channel activity

transmitter-gated monoatomic ion channel activity [inference]

transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential

ligand-gated monoatomic anion channel activity [inference]

extracellularly glycine-gated chloride channel activity

transmitter-gated channel activity [inference]

transmitter-gated monoatomic ion channel activity [inference]

transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential

salt transmembrane transporter activity [inference]

chloride transmembrane transporter activity [inference]

chloride channel activity

extracellularly glycine-gated chloride channel activity

binding [inference]

protein binding

small molecule binding [inference]

organic acid binding [inference]

carboxylic acid binding [inference]

amino acid binding [inference]

glycine binding

ion binding [inference]

anion binding [inference]

carboxylic acid binding [inference]

amino acid binding [inference]

glycine binding

cation binding [inference]

glycine binding

protein-containing complex binding

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity

neurotransmitter receptor activity

transmitter-gated channel activity [inference]

transmitter-gated monoatomic ion channel activity [inference]

transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential

postsynaptic neurotransmitter receptor activity [inference]

neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential [inference]

transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

glycine receptor, beta a

Functional Category

E: Amino acid transport and metabolism
T: Signal transduction mechanisms
X: Mobilome: prophages, transposons

Displaying **all 10** entries
Gene Ontology
chloride transmembrane transport
chloride transport
excitatory postsynaptic potential
extracellular ligand-gated monoatomic ion channel activity
glycine binding
monoatomic ion channel activity
monoatomic ion transport
neuropeptide signaling pathway
synaptic transmission, glycinergic
transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential

Displaying **all 8** entries
InterPro
Glycine receptor beta
Neuronal acetylcholine receptor
Neurotransmitter-gated ion-channel ligand-binding domain superfamily
Neurotransmitter-gated ion-channel ligand-binding domain
Neurotransmitter-gated ion-channel transmembrane domain superfamily
Neurotransmitter-gated ion-channel transmembrane domain
Neurotransmitter-gated ion-channel, conserved site
Neurotransmitter-gated ion-channel

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0060697	hyperekplexia 2	Alliance of Genome Resources

Ortholog

Displaying entries **31 - 40** of 92 in total

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Species	Gene ID	Orthologous MAtrix
Oryctolagus cuniculus	100342060	RABIT05034
Callithrix jacchus	100392393	CALJA29106
Meleagris gallopavo	100548283	MELGA09624
Anolis carolinensis	100567921	ANOCA07689
Nomascus leucogenys	100586448	NOMLE34168
Cavia porcellus	100727431	CAVPO04560
Cricetulus griseus	100764841	CRIGR07131
Pan paniscus	100981904	PANPA31188
Papio anubis	101025481	PAPAN26771
Saimiri boliviensis boliviensis	101038533	SAIBB13349