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Guidelines

MIRAGE

dopamine beta-hydroxylase

Summary

Gene Symbol

DBH

Organism

Bos taurus (domestic cattle)

External Links

NCBI Gene: 280758
PubChem: 280758

Annotation

Keyword

Catecholamine biosynthesis
Copper
Cytoplasmic vesicle
Direct protein sequencing
Disulfide bond
Glycoprotein
Metal-binding
Monooxygenase
Reference proteome
Signal-anchor
Transmembrane helix
Vitamin C

Proteins

Displaying 1 entry
UniProt	Protein Name
P15101	Dopamine beta-monooxygenase

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 3** entries
GO Term	Evidence Code	PMID
octopamine biosynthetic process	IEA	30032202
dopamine catabolic process	IEA	30032202
norepinephrine biosynthetic process	IEA	30032202

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amine biosynthetic process [inference]

biogenic amine biosynthetic process [inference]

octopamine biosynthetic process

catecholamine biosynthetic process [inference]

norepinephrine biosynthetic process

organonitrogen compound metabolic process [inference]

amine metabolic process [inference]

biogenic amine metabolic process [inference]

catecholamine metabolic process [inference]

norepinephrine metabolic process [inference]

norepinephrine biosynthetic process

dopamine metabolic process [inference]

dopamine catabolic process

catecholamine biosynthetic process [inference]

norepinephrine biosynthetic process

catecholamine catabolic process [inference]

dopamine catabolic process

biogenic amine biosynthetic process [inference]

octopamine biosynthetic process

catecholamine biosynthetic process [inference]

norepinephrine biosynthetic process

ethanolamine-containing compound metabolic process [inference]

octopamine metabolic process [inference]

octopamine biosynthetic process

amine biosynthetic process [inference]

biogenic amine biosynthetic process [inference]

octopamine biosynthetic process

catecholamine biosynthetic process [inference]

norepinephrine biosynthetic process

amine catabolic process [inference]

cellular biogenic amine catabolic process [inference]

catecholamine catabolic process [inference]

dopamine catabolic process

organonitrogen compound catabolic process [inference]

amine catabolic process [inference]

cellular biogenic amine catabolic process [inference]

catecholamine catabolic process [inference]

dopamine catabolic process

organonitrogen compound biosynthetic process [inference]

amine biosynthetic process [inference]

biogenic amine biosynthetic process [inference]

octopamine biosynthetic process

catecholamine biosynthetic process [inference]

norepinephrine biosynthetic process

catabolic process [inference]

cellular catabolic process [inference]

aromatic compound catabolic process [inference]

phenol-containing compound catabolic process [inference]

catechol-containing compound catabolic process [inference]

catecholamine catabolic process [inference]

dopamine catabolic process

organic substance catabolic process [inference]

organic cyclic compound catabolic process [inference]

phenol-containing compound catabolic process [inference]

catechol-containing compound catabolic process [inference]

catecholamine catabolic process [inference]

dopamine catabolic process

organonitrogen compound catabolic process [inference]

amine catabolic process [inference]

cellular biogenic amine catabolic process [inference]

catecholamine catabolic process [inference]

dopamine catabolic process

organic hydroxy compound catabolic process [inference]

phenol-containing compound catabolic process [inference]

catechol-containing compound catabolic process [inference]

catecholamine catabolic process [inference]

dopamine catabolic process

biosynthetic process [inference]

cellular biosynthetic process [inference]

aromatic compound biosynthetic process [inference]

phenol-containing compound biosynthetic process [inference]

octopamine biosynthetic process

catechol-containing compound biosynthetic process [inference]

catecholamine biosynthetic process [inference]

norepinephrine biosynthetic process

cellular nitrogen compound biosynthetic process [inference]

amine biosynthetic process [inference]

biogenic amine biosynthetic process [inference]

octopamine biosynthetic process

catecholamine biosynthetic process [inference]

norepinephrine biosynthetic process

small molecule biosynthetic process [inference]

alcohol biosynthetic process [inference]

octopamine biosynthetic process

organic substance biosynthetic process [inference]

organic cyclic compound biosynthetic process [inference]

phenol-containing compound biosynthetic process [inference]

octopamine biosynthetic process

catechol-containing compound biosynthetic process [inference]

catecholamine biosynthetic process [inference]

norepinephrine biosynthetic process

organonitrogen compound biosynthetic process [inference]

amine biosynthetic process [inference]

biogenic amine biosynthetic process [inference]

octopamine biosynthetic process

catecholamine biosynthetic process [inference]

norepinephrine biosynthetic process

organic hydroxy compound biosynthetic process [inference]

alcohol biosynthetic process [inference]

octopamine biosynthetic process

phenol-containing compound biosynthetic process [inference]

octopamine biosynthetic process

catechol-containing compound biosynthetic process [inference]

catecholamine biosynthetic process [inference]

norepinephrine biosynthetic process

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

phenol-containing compound metabolic process [inference]

catechol-containing compound metabolic process [inference]

catecholamine metabolic process [inference]

norepinephrine metabolic process [inference]

norepinephrine biosynthetic process

dopamine metabolic process [inference]

dopamine catabolic process

catecholamine biosynthetic process [inference]

norepinephrine biosynthetic process

catecholamine catabolic process [inference]

dopamine catabolic process

catechol-containing compound biosynthetic process [inference]

catecholamine biosynthetic process [inference]

norepinephrine biosynthetic process

catechol-containing compound catabolic process [inference]

catecholamine catabolic process [inference]

dopamine catabolic process

phenol-containing compound catabolic process [inference]

catechol-containing compound catabolic process [inference]

catecholamine catabolic process [inference]

dopamine catabolic process

phenol-containing compound biosynthetic process [inference]

octopamine biosynthetic process

catechol-containing compound biosynthetic process [inference]

catecholamine biosynthetic process [inference]

norepinephrine biosynthetic process

octopamine metabolic process [inference]

octopamine biosynthetic process

aromatic compound biosynthetic process [inference]

phenol-containing compound biosynthetic process [inference]

octopamine biosynthetic process

catechol-containing compound biosynthetic process [inference]

catecholamine biosynthetic process [inference]

norepinephrine biosynthetic process

aromatic compound catabolic process [inference]

phenol-containing compound catabolic process [inference]

catechol-containing compound catabolic process [inference]

catecholamine catabolic process [inference]

dopamine catabolic process

cellular nitrogen compound metabolic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amine biosynthetic process [inference]

biogenic amine biosynthetic process [inference]

octopamine biosynthetic process

catecholamine biosynthetic process [inference]

norepinephrine biosynthetic process

cellular catabolic process [inference]

aromatic compound catabolic process [inference]

phenol-containing compound catabolic process [inference]

catechol-containing compound catabolic process [inference]

catecholamine catabolic process [inference]

dopamine catabolic process

cellular biosynthetic process [inference]

aromatic compound biosynthetic process [inference]

phenol-containing compound biosynthetic process [inference]

octopamine biosynthetic process

catechol-containing compound biosynthetic process [inference]

catecholamine biosynthetic process [inference]

norepinephrine biosynthetic process

cellular nitrogen compound biosynthetic process [inference]

amine biosynthetic process [inference]

biogenic amine biosynthetic process [inference]

octopamine biosynthetic process

catecholamine biosynthetic process [inference]

norepinephrine biosynthetic process

small molecule metabolic process [inference]

alcohol metabolic process [inference]

ethanolamine-containing compound metabolic process [inference]

octopamine metabolic process [inference]

octopamine biosynthetic process

alcohol biosynthetic process [inference]

octopamine biosynthetic process

small molecule biosynthetic process [inference]

alcohol biosynthetic process [inference]

octopamine biosynthetic process

organic substance metabolic process [inference]

organic cyclic compound metabolic process [inference]

phenol-containing compound metabolic process [inference]

catechol-containing compound metabolic process [inference]

catecholamine metabolic process [inference]

norepinephrine metabolic process [inference]

norepinephrine biosynthetic process

dopamine metabolic process [inference]

dopamine catabolic process

catecholamine biosynthetic process [inference]

norepinephrine biosynthetic process

catecholamine catabolic process [inference]

dopamine catabolic process

catechol-containing compound biosynthetic process [inference]

catecholamine biosynthetic process [inference]

norepinephrine biosynthetic process

catechol-containing compound catabolic process [inference]

catecholamine catabolic process [inference]

dopamine catabolic process

phenol-containing compound catabolic process [inference]

catechol-containing compound catabolic process [inference]

catecholamine catabolic process [inference]

dopamine catabolic process

phenol-containing compound biosynthetic process [inference]

octopamine biosynthetic process

catechol-containing compound biosynthetic process [inference]

catecholamine biosynthetic process [inference]

norepinephrine biosynthetic process

octopamine metabolic process [inference]

octopamine biosynthetic process

organic cyclic compound catabolic process [inference]

phenol-containing compound catabolic process [inference]

catechol-containing compound catabolic process [inference]

catecholamine catabolic process [inference]

dopamine catabolic process

organic cyclic compound biosynthetic process [inference]

phenol-containing compound biosynthetic process [inference]

octopamine biosynthetic process

catechol-containing compound biosynthetic process [inference]

catecholamine biosynthetic process [inference]

norepinephrine biosynthetic process

organonitrogen compound metabolic process [inference]

amine metabolic process [inference]

biogenic amine metabolic process [inference]

catecholamine metabolic process [inference]

norepinephrine metabolic process [inference]

norepinephrine biosynthetic process

dopamine metabolic process [inference]

dopamine catabolic process

catecholamine biosynthetic process [inference]

norepinephrine biosynthetic process

catecholamine catabolic process [inference]

dopamine catabolic process

biogenic amine biosynthetic process [inference]

octopamine biosynthetic process

catecholamine biosynthetic process [inference]

norepinephrine biosynthetic process

ethanolamine-containing compound metabolic process [inference]

octopamine metabolic process [inference]

octopamine biosynthetic process

amine biosynthetic process [inference]

biogenic amine biosynthetic process [inference]

octopamine biosynthetic process

catecholamine biosynthetic process [inference]

norepinephrine biosynthetic process

amine catabolic process [inference]

cellular biogenic amine catabolic process [inference]

catecholamine catabolic process [inference]

dopamine catabolic process

organonitrogen compound catabolic process [inference]

amine catabolic process [inference]

cellular biogenic amine catabolic process [inference]

catecholamine catabolic process [inference]

dopamine catabolic process

organonitrogen compound biosynthetic process [inference]

amine biosynthetic process [inference]

biogenic amine biosynthetic process [inference]

octopamine biosynthetic process

catecholamine biosynthetic process [inference]

norepinephrine biosynthetic process

organic substance catabolic process [inference]

organic cyclic compound catabolic process [inference]

phenol-containing compound catabolic process [inference]

catechol-containing compound catabolic process [inference]

catecholamine catabolic process [inference]

dopamine catabolic process

organonitrogen compound catabolic process [inference]

amine catabolic process [inference]

cellular biogenic amine catabolic process [inference]

catecholamine catabolic process [inference]

dopamine catabolic process

organic hydroxy compound catabolic process [inference]

phenol-containing compound catabolic process [inference]

catechol-containing compound catabolic process [inference]

catecholamine catabolic process [inference]

dopamine catabolic process

organic substance biosynthetic process [inference]

organic cyclic compound biosynthetic process [inference]

phenol-containing compound biosynthetic process [inference]

octopamine biosynthetic process

catechol-containing compound biosynthetic process [inference]

catecholamine biosynthetic process [inference]

norepinephrine biosynthetic process

organonitrogen compound biosynthetic process [inference]

amine biosynthetic process [inference]

biogenic amine biosynthetic process [inference]

octopamine biosynthetic process

catecholamine biosynthetic process [inference]

norepinephrine biosynthetic process

organic hydroxy compound biosynthetic process [inference]

alcohol biosynthetic process [inference]

octopamine biosynthetic process

phenol-containing compound biosynthetic process [inference]

octopamine biosynthetic process

catechol-containing compound biosynthetic process [inference]

catecholamine biosynthetic process [inference]

norepinephrine biosynthetic process

organic hydroxy compound metabolic process [inference]

alcohol metabolic process [inference]

ethanolamine-containing compound metabolic process [inference]

octopamine metabolic process [inference]

octopamine biosynthetic process

alcohol biosynthetic process [inference]

octopamine biosynthetic process

phenol-containing compound metabolic process [inference]

catechol-containing compound metabolic process [inference]

catecholamine metabolic process [inference]

norepinephrine metabolic process [inference]

norepinephrine biosynthetic process

dopamine metabolic process [inference]

dopamine catabolic process

catecholamine biosynthetic process [inference]

norepinephrine biosynthetic process

catecholamine catabolic process [inference]

dopamine catabolic process

catechol-containing compound biosynthetic process [inference]

catecholamine biosynthetic process [inference]

norepinephrine biosynthetic process

catechol-containing compound catabolic process [inference]

catecholamine catabolic process [inference]

dopamine catabolic process

phenol-containing compound catabolic process [inference]

catechol-containing compound catabolic process [inference]

catecholamine catabolic process [inference]

dopamine catabolic process

phenol-containing compound biosynthetic process [inference]

octopamine biosynthetic process

catechol-containing compound biosynthetic process [inference]

catecholamine biosynthetic process [inference]

norepinephrine biosynthetic process

octopamine metabolic process [inference]

octopamine biosynthetic process

organic hydroxy compound catabolic process [inference]

phenol-containing compound catabolic process [inference]

catechol-containing compound catabolic process [inference]

catecholamine catabolic process [inference]

dopamine catabolic process

organic hydroxy compound biosynthetic process [inference]

alcohol biosynthetic process [inference]

octopamine biosynthetic process

phenol-containing compound biosynthetic process [inference]

octopamine biosynthetic process

catechol-containing compound biosynthetic process [inference]

catecholamine biosynthetic process [inference]

norepinephrine biosynthetic process

cellular process [inference]

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

phenol-containing compound metabolic process [inference]

catechol-containing compound metabolic process [inference]

catecholamine metabolic process [inference]

norepinephrine metabolic process [inference]

norepinephrine biosynthetic process

dopamine metabolic process [inference]

dopamine catabolic process

catecholamine biosynthetic process [inference]

norepinephrine biosynthetic process

catecholamine catabolic process [inference]

dopamine catabolic process

catechol-containing compound biosynthetic process [inference]

catecholamine biosynthetic process [inference]

norepinephrine biosynthetic process

catechol-containing compound catabolic process [inference]

catecholamine catabolic process [inference]

dopamine catabolic process

phenol-containing compound catabolic process [inference]

catechol-containing compound catabolic process [inference]

catecholamine catabolic process [inference]

dopamine catabolic process

phenol-containing compound biosynthetic process [inference]

octopamine biosynthetic process

catechol-containing compound biosynthetic process [inference]

catecholamine biosynthetic process [inference]

norepinephrine biosynthetic process

octopamine metabolic process [inference]

octopamine biosynthetic process

aromatic compound biosynthetic process [inference]

phenol-containing compound biosynthetic process [inference]

octopamine biosynthetic process

catechol-containing compound biosynthetic process [inference]

catecholamine biosynthetic process [inference]

norepinephrine biosynthetic process

aromatic compound catabolic process [inference]

phenol-containing compound catabolic process [inference]

catechol-containing compound catabolic process [inference]

catecholamine catabolic process [inference]

dopamine catabolic process

cellular nitrogen compound metabolic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amine biosynthetic process [inference]

biogenic amine biosynthetic process [inference]

octopamine biosynthetic process

catecholamine biosynthetic process [inference]

norepinephrine biosynthetic process

cellular catabolic process [inference]

aromatic compound catabolic process [inference]

phenol-containing compound catabolic process [inference]

catechol-containing compound catabolic process [inference]

catecholamine catabolic process [inference]

dopamine catabolic process

cellular biosynthetic process [inference]

aromatic compound biosynthetic process [inference]

phenol-containing compound biosynthetic process [inference]

octopamine biosynthetic process

catechol-containing compound biosynthetic process [inference]

catecholamine biosynthetic process [inference]

norepinephrine biosynthetic process

cellular nitrogen compound biosynthetic process [inference]

amine biosynthetic process [inference]

biogenic amine biosynthetic process [inference]

octopamine biosynthetic process

catecholamine biosynthetic process [inference]

norepinephrine biosynthetic process

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
extracellular space	IEA	30032202
transport vesicle membrane
secretory granule membrane	IEA	30032202
chromaffin granule lumen
secretory granule lumen

GO Hierarchy

cellular component

cellular anatomical entity [inference]

extracellular space

membrane [inference]

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

transport vesicle membrane

secretory granule membrane

chromaffin granule membrane

bounding membrane of organelle [inference]

transport vesicle membrane

secretory granule membrane

chromaffin granule membrane

membrane-enclosed lumen [inference]

organelle lumen [inference]

vesicle lumen [inference]

cytoplasmic vesicle lumen [inference]

secretory granule lumen

chromaffin granule lumen

intracellular organelle lumen [inference]

cytoplasmic vesicle lumen [inference]

secretory granule lumen

chromaffin granule lumen

Displaying **all 3** entries
GO Term	Evidence Code	PMID
dopamine beta-monooxygenase activity	IEA	30032202
copper ion binding	IEA	22301074 30032202
L-ascorbic acid binding

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

monooxygenase activity [inference]

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen [inference]

dopamine beta-monooxygenase activity

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [inference]

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen [inference]

dopamine beta-monooxygenase activity

binding [inference]

carbohydrate binding [inference]

monosaccharide binding [inference]

L-ascorbic acid binding

small molecule binding [inference]

vitamin binding [inference]

L-ascorbic acid binding

organic acid binding [inference]

carboxylic acid binding [inference]

L-ascorbic acid binding

monosaccharide binding [inference]

L-ascorbic acid binding

heterocyclic compound binding [inference]

L-ascorbic acid binding

ion binding [inference]

anion binding [inference]

carboxylic acid binding [inference]

L-ascorbic acid binding

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

copper ion binding

organic cyclic compound binding [inference]

L-ascorbic acid binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

DBH-like monooxygenase protein

Functional Category

C: Energy production and conversion
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 8** entries
Gene Ontology
catalytic activity
copper ion binding
dopamine beta-monooxygenase activity
dopamine catabolic process
monooxygenase activity
norepinephrine biosynthetic process
octopamine biosynthetic process
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen

Displaying **all 9** entries
InterPro
Copper type II ascorbate-dependent monooxygenase, C-terminal
Copper type II, ascorbate-dependent monooxygenase, N-terminal domain superfamily
Copper type II, ascorbate-dependent monooxygenase, N-terminal
Copper type II, ascorbate-dependent monooxygenase-like, C-terminal
Copper-dependent monooxygenases, DOMON domain
DOMON domain
Dopamine beta-hydroxylase-like
PHM/PNGase F domain superfamily
Tyramine beta-hydroxylase/Dopamine beta-hydroxylase

Ortholog

Displaying entries **41 - 50** of 65 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Macaca nemestrina	105471876		MACNE30051
Mandrillus leucophaeus	105547818		MANLE32289
Cercocebus atys	105580523		CERAT35446
Aotus nancymaae	105712191		AOTNA27056
Propithecus coquereli	105826696		PROCO31716
Dipodomys ordii	105995609		DIPOR20350
Salmo salar	106568424		SALSA26029
Equus asinus asinus	106845350		EQUAS24982
Sinocyclocheilus grahami	107595570		SINGR58480
Ictalurus punctatus	108276829		ICTPU08429

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Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: December 8, 2025