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NPC intracellular cholesterol transporter 2

Summary

Gene Symbol

NPC2

Organism

Bos taurus (domestic cattle)

External Links

NCBI Gene: 280815
PubChem: 280815

Annotation

Keyword

3D-structure
Acetylation
Cholesterol metabolism
Direct protein sequencing
Disulfide bond
Endoplasmic reticulum
Glycoprotein
Lipid transport
Lysosome
Reference proteome
Secreted
Signal

Proteins

Displaying **all 2** entries
UniProt	Protein Name
P79345	EPV20 Epididymal secretory protein E1 Niemann Pick type C2 protein homolog
A0AAF6Z9Z6	Epididymal secretory protein E1 Niemann Pick type C2 protein homolog

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 8 in total

1

2

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GO Term	Evidence Code	PMID
cholesterol metabolic process
response to virus
gene expression
cholesterol storage
cholesterol transport

GO Hierarchy

biological process

metabolic process [inference]

biosynthetic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

cellular metabolic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

primary metabolic process [inference]

lipid metabolic process [inference]

steroid metabolic process [inference]

sterol metabolic process [inference]

cholesterol metabolic process

small molecule metabolic process [inference]

alcohol metabolic process [inference]

secondary alcohol metabolic process [inference]

cholesterol metabolic process

organic substance metabolic process [inference]

lipid metabolic process [inference]

steroid metabolic process [inference]

sterol metabolic process [inference]

cholesterol metabolic process

macromolecule metabolic process [inference]

macromolecule biosynthetic process [inference]

gene expression

organic cyclic compound metabolic process [inference]

steroid metabolic process [inference]

sterol metabolic process [inference]

cholesterol metabolic process

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

organic hydroxy compound metabolic process [inference]

alcohol metabolic process [inference]

secondary alcohol metabolic process [inference]

cholesterol metabolic process

sterol metabolic process [inference]

cholesterol metabolic process

cellular process [inference]

cellular metabolic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

cellular localization [inference]

intracellular transport [inference]

intracellular lipid transport [inference]

intracellular sterol transport [inference]

intracellular cholesterol transport

homeostatic process [inference]

chemical homeostasis [inference]

lipid homeostasis [inference]

sterol homeostasis [inference]

cholesterol homeostasis

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

response to virus

response to stimulus [inference]

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to virus

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to virus

localization [inference]

establishment of localization [inference]

transport [inference]

intracellular transport [inference]

intracellular lipid transport [inference]

intracellular sterol transport [inference]

intracellular cholesterol transport

organic substance transport [inference]

lipid transport [inference]

sterol transport [inference]

cholesterol transport

intracellular sterol transport [inference]

intracellular cholesterol transport

intracellular lipid transport [inference]

intracellular sterol transport [inference]

intracellular cholesterol transport

organic hydroxy compound transport [inference]

sterol transport [inference]

cholesterol transport

intracellular sterol transport [inference]

intracellular cholesterol transport

establishment of localization in cell [inference]

intracellular transport [inference]

intracellular lipid transport [inference]

intracellular sterol transport [inference]

intracellular cholesterol transport

maintenance of location [inference]

lipid storage [inference]

cholesterol storage

cellular localization [inference]

intracellular transport [inference]

intracellular lipid transport [inference]

intracellular sterol transport [inference]

intracellular cholesterol transport

Displaying **all 3** entries
GO Term	Evidence Code	PMID
extracellular space
lysosome
endoplasmic reticulum

GO Hierarchy

cellular component

cellular anatomical entity [inference]

extracellular space

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

endoplasmic reticulum

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

endoplasmic reticulum

Displaying **all 3** entries
GO Term	Evidence Code	PMID
cholesterol binding	IEA	30032202
enzyme binding
cholesterol transfer activity

GO Hierarchy

molecular function

transporter activity [inference]

lipid transporter activity [inference]

sterol transporter activity [inference]

sterol transfer activity [inference]

cholesterol transfer activity

lipid transfer activity [inference]

sterol transfer activity [inference]

cholesterol transfer activity

binding [inference]

protein binding [inference]

enzyme binding

lipid binding [inference]

steroid binding [inference]

sterol binding [inference]

cholesterol binding

small molecule binding [inference]

alcohol binding [inference]

cholesterol binding

organic cyclic compound binding [inference]

steroid binding [inference]

sterol binding [inference]

cholesterol binding

Gene Ontology information from NCBI Gene and UniProt.

International Collaboration

GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: April 6, 2026

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