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LIF interleukin 6 family cytokine

Summary

Gene Symbol

LIF

Organism

Bos taurus (domestic cattle)

External Links

NCBI Gene: 280840
PubChem: 280840

Annotation

Keyword

Cytokine
Disulfide bond
Glycoprotein
Growth factor
Reference proteome
Secreted
Signal

Proteins

Displaying 1 entry
UniProt	Protein Name
Q27956	bLIF

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
positive regulation of cell population proliferation
regulation of cell communication
regulation of cell differentiation
leukemia inhibitory factor signaling pathway
immune response	IEA	22301074

GO Hierarchy

biological process

immune system process [inference]

immune response

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

leukemia inhibitory factor signaling pathway

response to stimulus [inference]

immune response

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cell population proliferation

regulation of developmental process [inference]

regulation of cell differentiation

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

leukemia inhibitory factor signaling pathway

regulation of cell communication

regulation of cell population proliferation [inference]

positive regulation of cell population proliferation

regulation of cell differentiation

positive regulation of cellular process [inference]

positive regulation of cell population proliferation

Displaying **all 2** entries
GO Term	Evidence Code	PMID
extracellular region	IEA	22301074 30032202
extracellular space

GO Hierarchy

cellular component

cellular anatomical entity [inference]

Displaying **all 3** entries
GO Term	Evidence Code	PMID
leukemia inhibitory factor receptor binding	IEA	22301074 30032202
cytokine activity	IEA	22301074
growth factor activity

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

signaling receptor binding [inference]

cytokine receptor binding [inference]

leukemia inhibitory factor receptor binding

receptor ligand activity [inference]

molecular function regulator activity [inference]

signaling receptor regulator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity [inference]

molecular function activator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity [inference]

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

leukemia inhibitory factor

Functional Category

E: Amino acid transport and metabolism
G: Carbohydrate transport and metabolism
Q: Secondary metabolites biosynthesis, transport and catabolism

Displaying **all 8** entries
Gene Ontology
cytokine activity
growth factor activity
immune response
leukemia inhibitory factor receptor binding
leukemia inhibitory factor signaling pathway
positive regulation of cell population proliferation
regulation of cell differentiation
signaling receptor binding

Displaying **all 3** entries
InterPro
Four-helical cytokine-like, core
Leukemia inhibitory factor /oncostatin
Leukemia inhibitory factor

Ortholog

Displaying entries **21 - 30** of 74 in total

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Species	Gene ID	OrthoDB	Orthologous MAtrix
Felis catus	101090296		FELCA28997
Ovis aries	101110180		SHEEP07515
Gorilla gorilla gorilla	101137862		GORGO24391
Tursiops truncatus	101318472	9739_0:002fef	TURTR13384
Jaculus jaculus	101617833		JACJA15966
Mustela putorius furo	101674557		MUSPF07399
Heterocephalus glaber	101713065		HETGA05005
Chrysemys picta bellii	101938752		CHRPI19416
Ictidomys tridecemlineatus	101976804		ICTTR11489
Chinchilla lanigera	102016978		CHILA14172