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MET proto-oncogene, receptor tyrosine kinase

Summary

Gene Symbol

Organism

Bos taurus (domestic cattle)

External Links

NCBI Gene: 280855
PubChem: 280855

Annotation

Keyword

ATP-binding
Disulfide bond
Glycoprotein
Phosphoprotein
Proto-oncogene
Receptor
Reference proteome
Repeat
Signal
Transmembrane helix
Tyrosine-protein kinase
Ubl conjugation

Proteins

Displaying 1 entry
UniProt	Protein Name
Q769I5	HGF/SF receptor Proto-oncogene c-Met Scatter factor receptor Tyrosine-protein kinase Met

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 13 in total

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GO Term	Evidence Code	PMID
liver development
protein phosphorylation	IEA	22301074
phagocytosis
transmembrane receptor protein tyrosine kinase signaling pathway	IEA	22301074
nervous system development

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phosphorylation [inference]

protein phosphorylation

primary metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation

macromolecule modification [inference]

protein modification process [inference]

protein phosphorylation

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

transmembrane receptor protein tyrosine kinase signaling pathway

semaphorin-plexin signaling pathway

semaphorin-plexin signaling pathway involved in neuron projection guidance [inference]

semaphorin-plexin signaling pathway involved in axon guidance

vesicle-mediated transport [inference]

endocytosis [inference]

phagocytosis

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phosphorylation [inference]

protein phosphorylation

cellular developmental process [inference]

cell differentiation [inference]

neuron differentiation

cell motility [inference]

cell migration

developmental process [inference]

anatomical structure development [inference]

animal organ development [inference]

pancreas development

gland development [inference]

liver development

system development [inference]

nervous system development

cellular developmental process [inference]

cell differentiation [inference]

neuron differentiation

locomotion [inference]

taxis [inference]

chemotaxis [inference]

positive chemotaxis

localization [inference]

establishment of localization [inference]

transport [inference]

vesicle-mediated transport [inference]

endocytosis [inference]

phagocytosis

import into cell [inference]

endocytosis [inference]

phagocytosis

biological regulation [inference]

regulation of biological process [inference]

regulation of locomotion [inference]

positive regulation of locomotion [inference]

positive regulation of chemotaxis [inference]

positive regulation of endothelial cell chemotaxis

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of epithelial cell migration [inference]

positive regulation of endothelial cell migration [inference]

positive regulation of endothelial cell chemotaxis

regulation of chemotaxis [inference]

positive regulation of chemotaxis [inference]

positive regulation of endothelial cell chemotaxis

regulation of endothelial cell chemotaxis [inference]

positive regulation of endothelial cell chemotaxis

regulation of cell motility [inference]

regulation of cell migration

regulation of epithelial cell migration [inference]

regulation of endothelial cell migration [inference]

positive regulation of endothelial cell migration [inference]

positive regulation of endothelial cell chemotaxis

regulation of endothelial cell chemotaxis [inference]

positive regulation of endothelial cell chemotaxis

positive regulation of epithelial cell migration [inference]

positive regulation of endothelial cell migration [inference]

positive regulation of endothelial cell chemotaxis

positive regulation of cell migration [inference]

positive regulation of epithelial cell migration [inference]

positive regulation of endothelial cell migration [inference]

positive regulation of endothelial cell chemotaxis

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of epithelial cell migration [inference]

positive regulation of endothelial cell migration [inference]

positive regulation of endothelial cell chemotaxis

positive regulation of biological process [inference]

positive regulation of locomotion [inference]

positive regulation of chemotaxis [inference]

positive regulation of endothelial cell chemotaxis

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of epithelial cell migration [inference]

positive regulation of endothelial cell migration [inference]

positive regulation of endothelial cell chemotaxis

positive regulation of cellular process [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of epithelial cell migration [inference]

positive regulation of endothelial cell migration [inference]

positive regulation of endothelial cell chemotaxis

positive regulation of response to stimulus [inference]

positive regulation of response to external stimulus [inference]

positive regulation of chemotaxis [inference]

positive regulation of endothelial cell chemotaxis

regulation of response to stimulus [inference]

regulation of response to external stimulus [inference]

positive regulation of response to external stimulus [inference]

positive regulation of chemotaxis [inference]

positive regulation of endothelial cell chemotaxis

regulation of chemotaxis [inference]

positive regulation of chemotaxis [inference]

positive regulation of endothelial cell chemotaxis

regulation of endothelial cell chemotaxis [inference]

positive regulation of endothelial cell chemotaxis

positive regulation of response to stimulus [inference]

positive regulation of response to external stimulus [inference]

positive regulation of chemotaxis [inference]

positive regulation of endothelial cell chemotaxis

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

transmembrane receptor protein tyrosine kinase signaling pathway

semaphorin-plexin signaling pathway

semaphorin-plexin signaling pathway involved in neuron projection guidance [inference]

semaphorin-plexin signaling pathway involved in axon guidance

positive regulation of cellular process [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of epithelial cell migration [inference]

positive regulation of endothelial cell migration [inference]

positive regulation of endothelial cell chemotaxis

regulation of cell motility [inference]

regulation of cell migration

regulation of epithelial cell migration [inference]

regulation of endothelial cell migration [inference]

positive regulation of endothelial cell migration [inference]

positive regulation of endothelial cell chemotaxis

regulation of endothelial cell chemotaxis [inference]

positive regulation of endothelial cell chemotaxis

positive regulation of epithelial cell migration [inference]

positive regulation of endothelial cell migration [inference]

positive regulation of endothelial cell chemotaxis

positive regulation of cell migration [inference]

positive regulation of epithelial cell migration [inference]

positive regulation of endothelial cell migration [inference]

positive regulation of endothelial cell chemotaxis

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of epithelial cell migration [inference]

positive regulation of endothelial cell migration [inference]

positive regulation of endothelial cell chemotaxis

regulation of multicellular organismal process [inference]

regulation of epithelial cell migration [inference]

regulation of endothelial cell migration [inference]

positive regulation of endothelial cell migration [inference]

positive regulation of endothelial cell chemotaxis

regulation of endothelial cell chemotaxis [inference]

positive regulation of endothelial cell chemotaxis

positive regulation of epithelial cell migration [inference]

positive regulation of endothelial cell migration [inference]

positive regulation of endothelial cell chemotaxis

Displaying **all 4** entries
GO Term	Evidence Code	PMID
semaphorin receptor complex	IEA	30032202
plasma membrane	IEA	30032202
basal plasma membrane
receptor complex

GO Hierarchy

cellular component

protein-containing complex [inference]

receptor complex

semaphorin receptor complex

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

plasma membrane region [inference]

basal plasma membrane

Displaying **all 5** entries
GO Term	Evidence Code	PMID
transmembrane receptor protein tyrosine kinase activity	IEA	22301074
hepatocyte growth factor receptor activity
protein binding	IEA	22301074
ATP binding	IEA	22301074
semaphorin receptor activity	IEA	30032202

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring phosphorus-containing groups [inference]

kinase activity [inference]

protein kinase activity [inference]

protein tyrosine kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity

hepatocyte growth factor receptor activity

transmembrane receptor protein kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity

hepatocyte growth factor receptor activity

phosphotransferase activity, alcohol group as acceptor [inference]

protein kinase activity [inference]

protein tyrosine kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity

hepatocyte growth factor receptor activity

transmembrane receptor protein kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity

hepatocyte growth factor receptor activity

catalytic activity, acting on a protein [inference]

protein kinase activity [inference]

protein tyrosine kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity

hepatocyte growth factor receptor activity

transmembrane receptor protein kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity

hepatocyte growth factor receptor activity

binding [inference]

protein binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

semaphorin receptor activity

transmembrane receptor protein kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity

hepatocyte growth factor receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Tyrosine- kinase

Functional Category

O: Posttranslational modification, protein turnover, chaperones
Q: Secondary metabolites biosynthesis, transport and catabolism
T: Signal transduction mechanisms

Displaying **all 4** entries
Gene Ontology
ATP binding
nucleotide binding
transmembrane receptor protein tyrosine kinase activity
transmembrane receptor protein tyrosine kinase signaling pathway

Displaying entries **1 - 10** of 15 in total

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InterPro
IPT domain
Immunoglobulin E-set
Immunoglobulin-like fold
PSI domain
Plexin repeat
Protein kinase domain
Protein kinase, ATP binding site
Protein kinase-like domain superfamily
Sema domain superfamily
Sema domain

Ortholog

Displaying entries **11 - 20** of 84 in total

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Species	Gene ID	Orthologous MAtrix
Equus caballus	100056013	HORSE31976
Ornithorhynchus anatinus	100079345	ORNAN01686
Oryctolagus cuniculus	100126565	RABIT11496
Papio anubis	100126669	PAPAN29861
Pongo abelii	100137030	PONAB33533
Takifugu rubripes	100137507	TAKRU51118
Danio rerio	100150664	DANRE27540
Taeniopygia guttata	100227998	TAEGU08141
Callithrix jacchus	100408551	CALJA43597
Ailuropoda melanoleuca	100480742	AILME14631

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OrthoDB (Group)

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Acknowledgements