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tubulin polymerization promoting protein

Summary

Gene Symbol

TPPP

Organism

Bos taurus (domestic cattle)

External Links

NCBI Gene: 280968
PubChem: 280968

Annotation

Keyword

Cytoskeleton
Direct protein sequencing
Glycoprotein
Golgi apparatus
Hydrolase
Magnesium
Metal-binding
Mitosis
Nucleus
Phosphoprotein
Reference proteome
Zinc

Proteins

Displaying 1 entry
UniProt	Protein Name
Q27957	25 kDa brain-specific protein p25-alpha

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 13 in total

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GO Term	Evidence Code	PMID
oligodendrocyte differentiation
positive regulation of myelination
positive regulation of protein polymerization	IEA	30032202
positive regulation of protein-containing complex assembly
regulation of microtubule cytoskeleton organization

GO Hierarchy

biological process

cellular process [inference]

microtubule-based process [inference]

microtubule cytoskeleton organization [inference]

microtubule bundle formation

microtubule nucleation [inference]

microtubule nucleation by microtubule organizing center

spindle organization [inference]

astral microtubule organization

microtubule polymerization or depolymerization [inference]

microtubule polymerization

cytoplasmic microtubule organization [inference]

astral microtubule organization

cell cycle process [inference]

spindle organization [inference]

astral microtubule organization

cellular developmental process [inference]

cell differentiation [inference]

glial cell differentiation [inference]

oligodendrocyte differentiation

cell development [inference]

glial cell development [inference]

oligodendrocyte development

cell division

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

cytoskeleton organization [inference]

microtubule cytoskeleton organization [inference]

microtubule bundle formation

microtubule nucleation [inference]

microtubule nucleation by microtubule organizing center

spindle organization [inference]

astral microtubule organization

microtubule polymerization or depolymerization [inference]

microtubule polymerization

cytoplasmic microtubule organization [inference]

astral microtubule organization

cellular component assembly [inference]

cellular component assembly involved in morphogenesis [inference]

myelin assembly

protein-containing complex assembly [inference]

protein polymerization [inference]

microtubule polymerization

protein-containing complex organization [inference]

protein-containing complex assembly [inference]

protein polymerization [inference]

microtubule polymerization

supramolecular fiber organization [inference]

cytoplasmic microtubule organization [inference]

astral microtubule organization

microtubule polymerization

developmental process [inference]

anatomical structure formation involved in morphogenesis [inference]

cellular component assembly involved in morphogenesis [inference]

myelin assembly

anatomical structure development [inference]

cell development [inference]

glial cell development [inference]

oligodendrocyte development

cellular developmental process [inference]

cell differentiation [inference]

glial cell differentiation [inference]

oligodendrocyte differentiation

cell development [inference]

glial cell development [inference]

oligodendrocyte development

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

negative regulation of metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of tubulin deacetylation

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of tubulin deacetylation

regulation of nitrogen compound metabolic process [inference]

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of tubulin deacetylation

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

negative regulation of protein modification process [inference]

negative regulation of tubulin deacetylation

regulation of protein deacetylation [inference]

regulation of tubulin deacetylation [inference]

negative regulation of tubulin deacetylation

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of tubulin deacetylation

regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of tubulin deacetylation

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

negative regulation of protein modification process [inference]

negative regulation of tubulin deacetylation

regulation of protein deacetylation [inference]

regulation of tubulin deacetylation [inference]

negative regulation of tubulin deacetylation

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of tubulin deacetylation

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

negative regulation of protein modification process [inference]

negative regulation of tubulin deacetylation

regulation of protein deacetylation [inference]

regulation of tubulin deacetylation [inference]

negative regulation of tubulin deacetylation

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of tubulin deacetylation

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of myelination

positive regulation of cellular component biogenesis [inference]

positive regulation of protein-containing complex assembly

positive regulation of protein polymerization

positive regulation of cellular component organization [inference]

positive regulation of protein-containing complex assembly

positive regulation of protein polymerization

positive regulation of multicellular organismal process [inference]

positive regulation of nervous system process [inference]

positive regulation of myelination

negative regulation of biological process [inference]

negative regulation of metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of tubulin deacetylation

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of tubulin deacetylation

regulation of developmental process [inference]

regulation of multicellular organismal development [inference]

regulation of nervous system development [inference]

regulation of myelination [inference]

positive regulation of myelination

regulation of cellular process [inference]

regulation of myelination [inference]

positive regulation of myelination

regulation of microtubule-based process [inference]

regulation of microtubule cytoskeleton organization

regulation of cellular component biogenesis [inference]

regulation of protein-containing complex assembly [inference]

positive regulation of protein-containing complex assembly

positive regulation of protein polymerization

regulation of protein polymerization [inference]

positive regulation of protein polymerization

positive regulation of cellular component biogenesis [inference]

positive regulation of protein-containing complex assembly

positive regulation of protein polymerization

positive regulation of cellular process [inference]

positive regulation of myelination

positive regulation of cellular component biogenesis [inference]

positive regulation of protein-containing complex assembly

positive regulation of protein polymerization

positive regulation of cellular component organization [inference]

positive regulation of protein-containing complex assembly

positive regulation of protein polymerization

regulation of cellular component organization [inference]

regulation of organelle organization [inference]

regulation of cytoskeleton organization [inference]

regulation of microtubule cytoskeleton organization

regulation of protein-containing complex assembly [inference]

positive regulation of protein-containing complex assembly

positive regulation of protein polymerization

regulation of protein polymerization [inference]

positive regulation of protein polymerization

positive regulation of cellular component organization [inference]

positive regulation of protein-containing complex assembly

positive regulation of protein polymerization

regulation of multicellular organismal process [inference]

regulation of system process [inference]

regulation of nervous system process [inference]

positive regulation of nervous system process [inference]

positive regulation of myelination

positive regulation of multicellular organismal process [inference]

positive regulation of nervous system process [inference]

positive regulation of myelination

regulation of multicellular organismal development [inference]

regulation of nervous system development [inference]

regulation of myelination [inference]

positive regulation of myelination

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
microtubule	IEA	30032202
microtubule organizing center
postsynaptic Golgi apparatus
nucleus
perinuclear region of cytoplasm

GO Hierarchy

cellular component

cellular anatomical entity [inference]

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

Golgi apparatus [inference]

postsynaptic Golgi apparatus

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

spindle [inference]

mitotic spindle

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

Golgi apparatus [inference]

postsynaptic Golgi apparatus

intracellular non-membrane-bounded organelle [inference]

spindle [inference]

mitotic spindle

perinuclear region of cytoplasm

supramolecular complex [inference]

supramolecular polymer [inference]

supramolecular fiber [inference]

polymeric cytoskeletal fiber [inference]

microtubule

Displaying **all 5** entries
GO Term	Evidence Code	PMID
GTPase activity
magnesium ion binding
microtubule binding
tubulin binding	IEA	22301074 30032202
protein homodimerization activity

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on acid anhydrides [inference]

hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [inference]

pyrophosphatase activity [inference]

ribonucleoside triphosphate phosphatase activity [inference]

GTPase activity

binding [inference]

protein binding [inference]

cytoskeletal protein binding [inference]

tubulin binding

microtubule binding

identical protein binding [inference]

protein homodimerization activity

protein dimerization activity [inference]

protein homodimerization activity

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

magnesium ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

tubulin polymerization-promoting protein

Functional Category

G: Carbohydrate transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 4** entries
Gene Ontology
microtubule bundle formation
microtubule polymerization
positive regulation of protein polymerization
tubulin binding

Displaying **all 2** entries
InterPro
EF-hand domain pair
Tubulin polymerization-promoting protein

Ortholog

Displaying entries **1 - 10** of **102** in total

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Species	Gene ID	OrthoDB	Orthologous MAtrix
Homo sapiens	11076		HUMAN78499
Mus musculus	72948		MOUSE10708
Rattus norvegicus	361466		RATNO19859
Pan troglodytes	461690		PANTR34984
Macaca mulatta	708834		MACMU38672
Sus scrofa	100144410	9823_0:004500	PIGXX11026
Ciona intestinalis	100182937		CIOIN13255
Taeniopygia guttata	100231796		TAEGU17233
Callithrix jacchus	100397219		CALJA25341
Pongo abelii	100458399		PONAB28967