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Guidelines

MIRAGE

alkaline phosphatase, biomineralization associated

Summary

Gene Symbol

ALPL

Organism

Bos taurus (domestic cattle)

External Links

NCBI Gene: 280994
KEGG Gene ID: bta:280994
PubChem: 280994

Annotation

Keyword

Biomineralization
Calcium
Cell membrane
Direct protein sequencing
Disulfide bond
GPI-anchor
Hydrolase
Magnesium
Metal-binding
Mitochondrion
Phosphoprotein
Reference proteome
Signal
Zinc

Proteins

Displaying 1 entry
UniProt	Protein Name
P09487	Alkaline phosphatase liver/bone/kidney isozyme Phosphoamidase Phosphocreatine phosphatase

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 17 in total

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GO Term	Evidence Code	PMID
endochondral ossification
developmental process involved in reproduction
dephosphorylation	IEA	30032202
cellular homeostasis
bone mineralization

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

pyridine-containing compound metabolic process [inference]

vitamin B6 metabolic process [inference]

pyridoxal phosphate metabolic process

organonitrogen compound metabolic process [inference]

pyridine-containing compound metabolic process [inference]

vitamin B6 metabolic process [inference]

pyridoxal phosphate metabolic process

cellular metabolic process [inference]

cellular aldehyde metabolic process [inference]

pyridoxal phosphate metabolic process

cellular aromatic compound metabolic process [inference]

pyridoxal phosphate metabolic process

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

organophosphate metabolic process [inference]

pyridoxal phosphate metabolic process

cellular nitrogen compound metabolic process [inference]

pyridine-containing compound metabolic process [inference]

vitamin B6 metabolic process [inference]

pyridoxal phosphate metabolic process

heterocycle metabolic process [inference]

pyridine-containing compound metabolic process [inference]

vitamin B6 metabolic process [inference]

pyridoxal phosphate metabolic process

small molecule metabolic process [inference]

vitamin metabolic process [inference]

water-soluble vitamin metabolic process [inference]

vitamin B6 metabolic process [inference]

pyridoxal phosphate metabolic process

organic substance metabolic process [inference]

cellular aldehyde metabolic process [inference]

pyridoxal phosphate metabolic process

organophosphate metabolic process [inference]

pyridoxal phosphate metabolic process

organic cyclic compound metabolic process [inference]

pyridine-containing compound metabolic process [inference]

vitamin B6 metabolic process [inference]

pyridoxal phosphate metabolic process

organonitrogen compound metabolic process [inference]

pyridine-containing compound metabolic process [inference]

vitamin B6 metabolic process [inference]

pyridoxal phosphate metabolic process

organic hydroxy compound metabolic process [inference]

pyridoxal phosphate metabolic process

futile creatine cycle

cellular process [inference]

cellular metabolic process [inference]

cellular aldehyde metabolic process [inference]

pyridoxal phosphate metabolic process

cellular aromatic compound metabolic process [inference]

pyridoxal phosphate metabolic process

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

organophosphate metabolic process [inference]

pyridoxal phosphate metabolic process

cellular nitrogen compound metabolic process [inference]

pyridine-containing compound metabolic process [inference]

vitamin B6 metabolic process [inference]

pyridoxal phosphate metabolic process

heterocycle metabolic process [inference]

pyridine-containing compound metabolic process [inference]

vitamin B6 metabolic process [inference]

pyridoxal phosphate metabolic process

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to organic cyclic compound

reproductive process [inference]

developmental process involved in reproduction

multicellular organismal process [inference]

ossification [inference]

replacement ossification [inference]

endochondral ossification

multicellular organismal-level homeostasis [inference]

anatomical structure homeostasis [inference]

tissue homeostasis [inference]

inhibition of non-skeletal tissue mineralization

developmental process [inference]

developmental process involved in reproduction

anatomical structure development [inference]

tissue development [inference]

biomineral tissue development

bone mineralization

homeostatic process [inference]

cellular homeostasis

multicellular organismal-level homeostasis [inference]

anatomical structure homeostasis [inference]

tissue homeostasis [inference]

inhibition of non-skeletal tissue mineralization

chemical homeostasis [inference]

monoatomic ion homeostasis [inference]

monoatomic cation homeostasis [inference]

calcium ion homeostasis

inorganic ion homeostasis [inference]

response to stimulus [inference]

response to external stimulus [inference]

response to extracellular stimulus [inference]

response to nutrient levels [inference]

response to nutrient [inference]

response to vitamin [inference]

response to chemical [inference]

response to nutrient [inference]

response to vitamin [inference]

response to organic substance [inference]

response to organonitrogen compound [inference]

response to vitamin B6

response to organic cyclic compound [inference]

response to lipid [inference]

response to vitamin D

cellular response to organic substance [inference]

cellular response to organic cyclic compound

response to inorganic substance [inference]

response to sodium phosphate

response to antibiotic

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to organic cyclic compound

response to nitrogen compound [inference]

response to organonitrogen compound [inference]

response to vitamin B6

response to oxygen-containing compound [inference]

response to salt [inference]

response to sodium phosphate

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to organic cyclic compound

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

positive regulation of metabolic process [inference]

positive regulation of cold-induced thermogenesis

regulation of cold-induced thermogenesis [inference]

positive regulation of cold-induced thermogenesis

positive regulation of biological process [inference]

positive regulation of metabolic process [inference]

positive regulation of cold-induced thermogenesis

positive regulation of multicellular organismal process [inference]

positive regulation of cold-induced thermogenesis

regulation of multicellular organismal process [inference]

positive regulation of multicellular organismal process [inference]

positive regulation of cold-induced thermogenesis

regulation of cold-induced thermogenesis [inference]

positive regulation of cold-induced thermogenesis

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
mitochondrial intermembrane space
plasma membrane	IEA	30032202
extracellular matrix
mitochondrial membrane
extracellular membrane-bounded organelle

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

organelle membrane [inference]

mitochondrial membrane

external encapsulating structure [inference]

extracellular matrix

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

organelle envelope lumen [inference]

mitochondrial intermembrane space

organelle [inference]

membrane-bounded organelle [inference]

extracellular membrane-bounded organelle

extracellular organelle [inference]

extracellular membrane-bounded organelle

side of membrane

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
alkaline phosphatase activity	IEA	30032202
inorganic diphosphate phosphatase activity
calcium ion binding
pyrophosphatase activity
ATP hydrolysis activity

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on ester bonds [inference]

phosphoric ester hydrolase activity [inference]

phosphatase activity [inference]

hydrolase activity, acting on acid anhydrides [inference]

hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [inference]

pyrophosphatase activity

inorganic diphosphate phosphatase activity

nucleoside diphosphate phosphatase activity [inference]

ADP phosphatase activity

ribonucleoside triphosphate phosphatase activity [inference]

ATP hydrolysis activity

hydrolase activity, acting on acid phosphorus-nitrogen bonds [inference]

phosphoamidase activity

binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

calcium ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

alkaline phosphatase

Functional Category

I: Lipid transport and metabolism
T: Signal transduction mechanisms
V: Defense mechanisms

Displaying **all 4** entries
Gene Ontology
alkaline phosphatase activity
dephosphorylation
hydrolase activity
metal ion binding

Displaying **all 3** entries
InterPro
Alkaline phosphatase, active site
Alkaline phosphatase
Alkaline-phosphatase-like, core domain superfamily

KEGG BRITE Database

Orthology

K01077

Name

alkaline phosphatase [EC:3.1.3.1]

References

10628988

Rhea

H₂O + a phosphate monoester

an alcohol + phosphate

Enzyme

PMID

H₂O + N-phosphocreatine

phosphate + creatine

Enzyme

3.9.1.1

PMID

Ortholog

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	249		HUMAN47927
Mus musculus	11647		MOUSE41351
Rattus norvegicus	25586		RATNO32949
Danio rerio	393982		DANRE03106
Canis lupus familiaris	403548		CANLF07067
Ciona intestinalis	445594		CIOIN16078
Pan troglodytes	456600		PANTR20173
Macaca mulatta	717809		MACMU23170
Felis catus	727689		FELCA18496
Monodelphis domestica	100026689		MONDO24070

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Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: December 8, 2025