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apolipoprotein E

Summary

Gene Symbol

APOE

Organism

Bos taurus (domestic cattle)

External Links

NCBI Gene: 281004
PubChem: 281004

Annotation

Keyword

Chylomicron
Endosome
Extracellular matrix
Glycoprotein
HDL
Heparin-binding
Lipid transport
Lipid-binding
Oxidation
Phosphoprotein
Reference proteome
Repeat
Signal
VLDL

Proteins

Displaying 1 entry
UniProt	Protein Name
Q03247

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **16 - 19** of 19 in total

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GO Term	Evidence Code	PMID
intermediate-density lipoprotein particle clearance
regulation of amyloid-beta clearance	IEA	30032202
positive regulation of amyloid-beta clearance
negative regulation of amyloid fibril formation

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein catabolic process [inference]

lipoprotein catabolic process

lipoprotein metabolic process [inference]

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

lipoprotein catabolic process

organonitrogen compound biosynthetic process [inference]

lipoprotein biosynthetic process

catabolic process [inference]

small molecule catabolic process [inference]

alcohol catabolic process [inference]

cholesterol catabolic process

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

lipoprotein catabolic process

lipid catabolic process [inference]

steroid catabolic process [inference]

sterol catabolic process [inference]

cholesterol catabolic process

organic cyclic compound catabolic process [inference]

steroid catabolic process [inference]

sterol catabolic process [inference]

cholesterol catabolic process

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

lipoprotein catabolic process

organic hydroxy compound catabolic process [inference]

sterol catabolic process [inference]

cholesterol catabolic process

alcohol catabolic process [inference]

cholesterol catabolic process

biosynthetic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

lipoprotein biosynthetic process

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

lipoprotein biosynthetic process

organonitrogen compound biosynthetic process [inference]

lipoprotein biosynthetic process

cellular metabolic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

lipoprotein biosynthetic process

primary metabolic process [inference]

lipid metabolic process [inference]

steroid metabolic process [inference]

steroid catabolic process [inference]

sterol catabolic process [inference]

cholesterol catabolic process

sterol metabolic process [inference]

cholesterol metabolic process

cholesterol catabolic process

sterol catabolic process [inference]

cholesterol catabolic process

lipid catabolic process [inference]

steroid catabolic process [inference]

sterol catabolic process [inference]

cholesterol catabolic process

protein metabolic process [inference]

protein catabolic process [inference]

lipoprotein catabolic process

lipoprotein metabolic process [inference]

small molecule metabolic process [inference]

alcohol metabolic process [inference]

alcohol catabolic process [inference]

cholesterol catabolic process

secondary alcohol metabolic process [inference]

cholesterol metabolic process

cholesterol catabolic process

small molecule catabolic process [inference]

alcohol catabolic process [inference]

cholesterol catabolic process

organic substance metabolic process [inference]

lipid metabolic process [inference]

steroid metabolic process [inference]

steroid catabolic process [inference]

sterol catabolic process [inference]

cholesterol catabolic process

sterol metabolic process [inference]

cholesterol metabolic process

cholesterol catabolic process

sterol catabolic process [inference]

cholesterol catabolic process

lipid catabolic process [inference]

steroid catabolic process [inference]

sterol catabolic process [inference]

cholesterol catabolic process

macromolecule metabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

lipoprotein catabolic process

macromolecule biosynthetic process [inference]

lipoprotein biosynthetic process

protein metabolic process [inference]

protein catabolic process [inference]

lipoprotein catabolic process

lipoprotein metabolic process [inference]

organic cyclic compound metabolic process [inference]

steroid metabolic process [inference]

steroid catabolic process [inference]

sterol catabolic process [inference]

cholesterol catabolic process

sterol metabolic process [inference]

cholesterol metabolic process

cholesterol catabolic process

sterol catabolic process [inference]

cholesterol catabolic process

organic cyclic compound catabolic process [inference]

steroid catabolic process [inference]

sterol catabolic process [inference]

cholesterol catabolic process

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein catabolic process [inference]

lipoprotein catabolic process

lipoprotein metabolic process [inference]

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

lipoprotein catabolic process

organonitrogen compound biosynthetic process [inference]

lipoprotein biosynthetic process

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

lipoprotein catabolic process

lipid catabolic process [inference]

steroid catabolic process [inference]

sterol catabolic process [inference]

cholesterol catabolic process

organic cyclic compound catabolic process [inference]

steroid catabolic process [inference]

sterol catabolic process [inference]

cholesterol catabolic process

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

lipoprotein catabolic process

organic hydroxy compound catabolic process [inference]

sterol catabolic process [inference]

cholesterol catabolic process

alcohol catabolic process [inference]

cholesterol catabolic process

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

lipoprotein biosynthetic process

organonitrogen compound biosynthetic process [inference]

lipoprotein biosynthetic process

organic hydroxy compound metabolic process [inference]

alcohol metabolic process [inference]

alcohol catabolic process [inference]

cholesterol catabolic process

secondary alcohol metabolic process [inference]

cholesterol metabolic process

cholesterol catabolic process

sterol metabolic process [inference]

cholesterol metabolic process

cholesterol catabolic process

sterol catabolic process [inference]

cholesterol catabolic process

organic hydroxy compound catabolic process [inference]

sterol catabolic process [inference]

cholesterol catabolic process

alcohol catabolic process [inference]

cholesterol catabolic process

cellular process [inference]

cellular metabolic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

lipoprotein biosynthetic process

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

vesicle organization [inference]

pigment granule organization [inference]

melanosome organization

cellular component assembly [inference]

protein-containing complex assembly [inference]

protein-lipid complex assembly [inference]

plasma lipoprotein particle assembly [inference]

high-density lipoprotein particle assembly

protein-containing complex organization [inference]

protein-containing complex assembly [inference]

protein-lipid complex assembly [inference]

plasma lipoprotein particle assembly [inference]

high-density lipoprotein particle assembly

protein-lipid complex organization [inference]

protein-lipid complex assembly [inference]

plasma lipoprotein particle assembly [inference]

high-density lipoprotein particle assembly

plasma lipoprotein particle organization [inference]

plasma lipoprotein particle assembly [inference]

high-density lipoprotein particle assembly

multicellular organismal process [inference]

plasma lipoprotein particle clearance [inference]

very-low-density lipoprotein particle clearance

triglyceride-rich lipoprotein particle clearance

plasma lipoprotein particle organization [inference]

plasma lipoprotein particle assembly [inference]

high-density lipoprotein particle assembly

homeostatic process [inference]

chemical homeostasis [inference]

lipid homeostasis [inference]

acylglycerol homeostasis

localization [inference]

establishment of localization [inference]

transport [inference]

organic substance transport [inference]

lipid transport

phospholipid transport [inference]

phospholipid efflux

sterol transport [inference]

cholesterol transport [inference]

cholesterol efflux

organophosphate ester transport [inference]

phospholipid transport [inference]

phospholipid efflux

organic hydroxy compound transport [inference]

sterol transport [inference]

cholesterol transport [inference]

cholesterol efflux

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

negative regulation of metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of amyloid fibril formation

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of amyloid fibril formation

regulation of nitrogen compound metabolic process [inference]

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of amyloid fibril formation

regulation of protein metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of amyloid fibril formation

regulation of amyloid fibril formation [inference]

negative regulation of amyloid fibril formation

regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of amyloid fibril formation

regulation of protein metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of amyloid fibril formation

regulation of amyloid fibril formation [inference]

negative regulation of amyloid fibril formation

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of amyloid fibril formation

regulation of amyloid fibril formation [inference]

negative regulation of amyloid fibril formation

positive regulation of biological process [inference]

positive regulation of multicellular organismal process [inference]

positive regulation of amyloid-beta clearance

negative regulation of biological process [inference]

negative regulation of metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of amyloid fibril formation

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of amyloid fibril formation

negative regulation of cellular process [inference]

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process [inference]

negative regulation of neuron apoptotic process

negative regulation of cellular component organization [inference]

negative regulation of supramolecular fiber organization [inference]

negative regulation of amyloid fibril formation

regulation of cellular process [inference]

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

negative regulation of apoptotic process [inference]

negative regulation of neuron apoptotic process

regulation of neuron apoptotic process [inference]

negative regulation of neuron apoptotic process

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process [inference]

negative regulation of neuron apoptotic process

negative regulation of cellular process [inference]

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process [inference]

negative regulation of neuron apoptotic process

negative regulation of cellular component organization [inference]

negative regulation of supramolecular fiber organization [inference]

negative regulation of amyloid fibril formation

regulation of cellular component organization [inference]

negative regulation of cellular component organization [inference]

negative regulation of supramolecular fiber organization [inference]

negative regulation of amyloid fibril formation

regulation of supramolecular fiber organization [inference]

negative regulation of supramolecular fiber organization [inference]

negative regulation of amyloid fibril formation

regulation of amyloid fibril formation [inference]

negative regulation of amyloid fibril formation

regulation of multicellular organismal process [inference]

positive regulation of multicellular organismal process [inference]

positive regulation of amyloid-beta clearance

regulation of amyloid-beta clearance

positive regulation of amyloid-beta clearance

regulation of molecular function [inference]

positive regulation of molecular function [inference]

positive regulation of catalytic activity [inference]

positive regulation of oxidoreductase activity [inference]

positive regulation of monooxygenase activity [inference]

positive regulation of nitric-oxide synthase activity

regulation of catalytic activity [inference]

positive regulation of catalytic activity [inference]

positive regulation of oxidoreductase activity [inference]

positive regulation of monooxygenase activity [inference]

positive regulation of nitric-oxide synthase activity

regulation of oxidoreductase activity [inference]

regulation of monooxygenase activity [inference]

positive regulation of monooxygenase activity [inference]

positive regulation of nitric-oxide synthase activity

regulation of nitric-oxide synthase activity [inference]

positive regulation of nitric-oxide synthase activity

positive regulation of oxidoreductase activity [inference]

positive regulation of monooxygenase activity [inference]

positive regulation of nitric-oxide synthase activity

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
extracellular region	IEA	22301074
extracellular space
extracellular matrix
very-low-density lipoprotein particle
low-density lipoprotein particle

GO Hierarchy

cellular component

protein-containing complex [inference]

protein-lipid complex [inference]

lipoprotein particle [inference]

plasma lipoprotein particle [inference]

triglyceride-rich plasma lipoprotein particle [inference]

chylomicron

cellular anatomical entity [inference]

external encapsulating structure [inference]

extracellular matrix

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

multivesicular body, internal vesicle

extracellular vesicle

extracellular exosome

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

multivesicular body, internal vesicle

extracellular membrane-bounded organelle [inference]

extracellular vesicle

extracellular exosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

multivesicular body, internal vesicle

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle

extracellular exosome

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
amyloid-beta binding	IEA	30032202
phospholipid binding
heparin binding
lipid binding	IEA	22301074
identical protein binding

GO Hierarchy

molecular function

transporter activity [inference]

lipid transporter activity [inference]

sterol transporter activity [inference]

sterol transfer activity [inference]

cholesterol transfer activity

lipid transfer activity [inference]

sterol transfer activity [inference]

cholesterol transfer activity

binding [inference]

protein binding [inference]

signaling receptor binding [inference]

lipoprotein particle receptor binding [inference]

identical protein binding

proteoglycan binding [inference]

heparan sulfate proteoglycan binding

lipid binding

phospholipid binding

amide binding [inference]

peptide binding [inference]

amyloid-beta binding

carbohydrate derivative binding [inference]

glycosaminoglycan binding [inference]

heparin binding

proteoglycan binding [inference]

heparan sulfate proteoglycan binding

sulfur compound binding [inference]

molecular function regulator activity [inference]

enzyme regulator activity [inference]

enzyme activator activity [inference]

phosphatidylcholine-sterol O-acyltransferase activator activity

molecular function activator activity [inference]

enzyme activator activity [inference]

phosphatidylcholine-sterol O-acyltransferase activator activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Apolipoprotein E

Functional Category

L: Replication, recombination and repair
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying entries **11 - 14** of 14 in total

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Gene Ontology
regulation of intestinal cholesterol absorption
reverse cholesterol transport
triglyceride homeostasis
very-low-density lipoprotein particle remodeling

Displaying 1 entry
InterPro
Apolipoprotein A/E

Ortholog

Displaying entries **1 - 10** of 83 in total

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Species	Gene ID	Orthologous MAtrix
Homo sapiens	348	HUMAN44284
Mus musculus	11816	MOUSE53726
Rattus norvegicus	25728	RATNO16263
Danio rerio	30314	DANRE10814
Sus scrofa	397576	PIGXX28040
Pan troglodytes	449586	PANTR18605
Canis lupus familiaris	476438	CANLF00952
Danio rerio	553587	DANRE16364
Macaca mulatta	714623	MACMU19030
Takifugu rubripes	777965	TAKRU05082

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Acknowledgements