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cytochrome b-245 beta chain

Summary

Gene Symbol

CYBB

Organism

Bos taurus (domestic cattle)

External Links

NCBI Gene: 281112
PubChem: 281112

Annotation

Keyword

Cell membrane
Electron transport
FAD
Glycoprotein
Heme
Isopeptide bond
NADP
Oxidoreductase
Phosphoprotein
Reference proteome
Transmembrane helix
Ubl conjugation
Voltage-gated channel

Proteins

Displaying 1 entry
UniProt	Protein Name
O46522	CGD91-phox Cytochrome b(558) subunit beta Heme-binding membrane glycoprotein gp91phox Neutrophil cytochrome b 91 kDa polypeptide gp91-1 gp91-phox p22 phagocyte B-cytochrome

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 5** entries
GO Term	Evidence Code	PMID
superoxide metabolic process
defense response	IEA	30032202
inflammatory response
superoxide anion generation	IEA	30032202
innate immune response

GO Hierarchy

biological process

immune system process [inference]

immune response [inference]

innate immune response

metabolic process [inference]

cellular metabolic process [inference]

reactive oxygen species metabolic process [inference]

superoxide metabolic process

superoxide anion generation

cellular process [inference]

cellular metabolic process [inference]

reactive oxygen species metabolic process [inference]

superoxide metabolic process

superoxide anion generation

transmembrane transport [inference]

monoatomic ion transmembrane transport

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

defense response to other organism [inference]

innate immune response

response to stimulus [inference]

response to stress [inference]

defense response

inflammatory response

defense response to other organism [inference]

innate immune response

immune response [inference]

innate immune response

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

defense response to other organism [inference]

innate immune response

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

defense response to other organism [inference]

innate immune response

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

ion transmembrane transport

transmembrane transport [inference]

monoatomic ion transmembrane transport

Displaying **all 5** entries
GO Term	Evidence Code	PMID
lysosome
plasma membrane	IEA	30032202
monoatomic ion channel complex
NADPH oxidase complex	IEA	30032202
membrane raft

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

plasma membrane protein complex [inference]

NADPH oxidase complex

transmembrane transporter complex [inference]

monoatomic ion channel complex

catalytic complex [inference]

oxidoreductase complex [inference]

NADPH oxidase complex

transporter complex [inference]

transmembrane transporter complex [inference]

monoatomic ion channel complex

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

membrane microdomain [inference]

membrane raft

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

Displaying **all 2** entries
GO Term	Evidence Code	PMID
superoxide-generating NAD(P)H oxidase activity	IEA	30032202
metal ion binding

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

oxidoreductase activity, acting on NAD(P)H [inference]

oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor [inference]

superoxide-generating NAD(P)H oxidase activity

binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

nadph oxidase

Functional Category

C: Energy production and conversion
Q: Secondary metabolites biosynthesis, transport and catabolism
T: Signal transduction mechanisms

Displaying **all 3** entries
Gene Ontology
oxidoreductase activity
superoxide anion generation
superoxide-generating NAD(P)H oxidase activity

Displaying **all 7** entries
InterPro
Cytochrome b245, heavy chain
FAD-binding 8
FAD-binding domain, ferredoxin reductase-type
Ferredoxin-NADP reductase (FNR), nucleotide-binding domain
Ferric reductase transmembrane component-like domain
Ferric reductase, NAD binding domain
Riboflavin synthase-like beta-barrel

Ortholog

Displaying entries **1 - 10** of 71 in total

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Species	Gene ID	Orthologous MAtrix
Homo sapiens	1536	HUMAN100170
Mus musculus	13058	MOUSE66390
Rattus norvegicus	66021	RATNO45304
Sus scrofa	397108	PIGXX37152
Takifugu rubripes	445888	TAKRU48429
Pan troglodytes	465566	PANTR45745
Canis lupus familiaris	491825	CANLF19678
Macaca mulatta	696542	MACMU47192
Monodelphis domestica	100017914	MONDO21154
Ovis aries	100036757	SHEEP19641

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements