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dopamine receptor D2

Summary

Gene Symbol

DRD2

Organism

Bos taurus (domestic cattle)

External Links

NCBI Gene: 281126
PubChem: 281126

Annotation

Keyword

Alternative splicing
Cell membrane
Disulfide bond
G-protein coupled receptor
Glycoprotein
Golgi apparatus
Palmitate
Reference proteome
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
P20288	Dopamine D2 receptor
F1N4I3	Dopamine D2 receptor

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	PMID
negative regulation of synaptic transmission, glutamatergic
adenylate cyclase-inhibiting dopamine receptor signaling pathway	IEA	22301074
positive regulation of MAPK cascade
regulation of potassium ion transport
hyaloid vascular plexus regression

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-modulating G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-activating G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-activating adrenergic receptor signaling pathway

adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-inhibiting dopamine receptor signaling pathway

phospholipase C-activating G protein-coupled receptor signaling pathway [inference]

phospholipase C-activating dopamine receptor signaling pathway

adrenergic receptor signaling pathway [inference]

adenylate cyclase-activating adrenergic receptor signaling pathway

dopamine receptor signaling pathway [inference]

developmental process [inference]

anatomical structure regression [inference]

hyaloid vascular plexus regression

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

positive regulation of MAPK cascade

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

negative regulation of signaling [inference]

negative regulation of hormone secretion [inference]

negative regulation of peptide hormone secretion [inference]

negative regulation of prolactin secretion

negative regulation of synaptic transmission [inference]

negative regulation of synaptic transmission, glutamatergic

regulation of hormone secretion [inference]

negative regulation of hormone secretion [inference]

negative regulation of peptide hormone secretion [inference]

negative regulation of prolactin secretion

regulation of peptide hormone secretion [inference]

negative regulation of peptide hormone secretion [inference]

negative regulation of prolactin secretion

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

negative regulation of synaptic transmission [inference]

negative regulation of synaptic transmission, glutamatergic

regulation of synaptic transmission, glutamatergic [inference]

negative regulation of synaptic transmission, glutamatergic

regulation of localization [inference]

regulation of transport [inference]

regulation of monoatomic ion transport [inference]

regulation of metal ion transport [inference]

regulation of potassium ion transport

regulation of secretion [inference]

regulation of peptide secretion [inference]

negative regulation of peptide secretion [inference]

negative regulation of peptide hormone secretion [inference]

negative regulation of prolactin secretion

regulation of peptide hormone secretion [inference]

negative regulation of peptide hormone secretion [inference]

negative regulation of prolactin secretion

negative regulation of secretion [inference]

negative regulation of peptide secretion [inference]

negative regulation of peptide hormone secretion [inference]

negative regulation of prolactin secretion

negative regulation of lactation

negative regulation of secretion by cell [inference]

negative regulation of hormone secretion [inference]

negative regulation of peptide hormone secretion [inference]

negative regulation of prolactin secretion

negative regulation of protein secretion [inference]

negative regulation of prolactin secretion

regulation of lactation [inference]

negative regulation of lactation

regulation of secretion by cell [inference]

regulation of hormone secretion [inference]

negative regulation of hormone secretion [inference]

negative regulation of peptide hormone secretion [inference]

negative regulation of prolactin secretion

regulation of peptide hormone secretion [inference]

negative regulation of peptide hormone secretion [inference]

negative regulation of prolactin secretion

regulation of catecholamine secretion [inference]

regulation of dopamine secretion

regulation of protein secretion [inference]

negative regulation of protein secretion [inference]

negative regulation of prolactin secretion

negative regulation of secretion by cell [inference]

negative regulation of hormone secretion [inference]

negative regulation of peptide hormone secretion [inference]

negative regulation of prolactin secretion

negative regulation of protein secretion [inference]

negative regulation of prolactin secretion

negative regulation of transport [inference]

negative regulation of secretion [inference]

negative regulation of peptide secretion [inference]

negative regulation of peptide hormone secretion [inference]

negative regulation of prolactin secretion

negative regulation of lactation

negative regulation of secretion by cell [inference]

negative regulation of hormone secretion [inference]

negative regulation of peptide hormone secretion [inference]

negative regulation of prolactin secretion

negative regulation of protein secretion [inference]

negative regulation of prolactin secretion

negative regulation of protein transport [inference]

negative regulation of protein secretion [inference]

negative regulation of prolactin secretion

regulation of protein transport [inference]

regulation of protein secretion [inference]

negative regulation of protein secretion [inference]

negative regulation of prolactin secretion

negative regulation of protein transport [inference]

negative regulation of protein secretion [inference]

negative regulation of prolactin secretion

regulation of amine transport [inference]

regulation of catecholamine secretion [inference]

regulation of dopamine secretion

regulation of peptide transport [inference]

regulation of peptide secretion [inference]

negative regulation of peptide secretion [inference]

negative regulation of peptide hormone secretion [inference]

negative regulation of prolactin secretion

regulation of peptide hormone secretion [inference]

negative regulation of peptide hormone secretion [inference]

negative regulation of prolactin secretion

regulation of cellular localization [inference]

regulation of protein localization [inference]

regulation of establishment of protein localization [inference]

regulation of protein transport [inference]

regulation of protein secretion [inference]

negative regulation of protein secretion [inference]

negative regulation of prolactin secretion

negative regulation of protein transport [inference]

negative regulation of protein secretion [inference]

negative regulation of prolactin secretion

negative regulation of establishment of protein localization [inference]

negative regulation of protein transport [inference]

negative regulation of protein secretion [inference]

negative regulation of prolactin secretion

negative regulation of protein localization [inference]

negative regulation of establishment of protein localization [inference]

negative regulation of protein transport [inference]

negative regulation of protein secretion [inference]

negative regulation of prolactin secretion

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of multicellular organismal process [inference]

positive regulation of tissue remodeling [inference]

positive regulation of mammary gland involution

negative regulation of biological process [inference]

negative regulation of signaling [inference]

negative regulation of hormone secretion [inference]

negative regulation of peptide hormone secretion [inference]

negative regulation of prolactin secretion

negative regulation of synaptic transmission [inference]

negative regulation of synaptic transmission, glutamatergic

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of hormone secretion [inference]

negative regulation of peptide hormone secretion [inference]

negative regulation of prolactin secretion

negative regulation of synaptic transmission [inference]

negative regulation of synaptic transmission, glutamatergic

negative regulation of secretion by cell [inference]

negative regulation of hormone secretion [inference]

negative regulation of peptide hormone secretion [inference]

negative regulation of prolactin secretion

negative regulation of protein secretion [inference]

negative regulation of prolactin secretion

negative regulation of protein localization [inference]

negative regulation of establishment of protein localization [inference]

negative regulation of protein transport [inference]

negative regulation of protein secretion [inference]

negative regulation of prolactin secretion

negative regulation of transport [inference]

negative regulation of secretion [inference]

negative regulation of peptide secretion [inference]

negative regulation of peptide hormone secretion [inference]

negative regulation of prolactin secretion

negative regulation of lactation

negative regulation of secretion by cell [inference]

negative regulation of hormone secretion [inference]

negative regulation of peptide hormone secretion [inference]

negative regulation of prolactin secretion

negative regulation of protein secretion [inference]

negative regulation of prolactin secretion

negative regulation of protein transport [inference]

negative regulation of protein secretion [inference]

negative regulation of prolactin secretion

negative regulation of developmental process [inference]

negative regulation of lactation

negative regulation of multicellular organismal process [inference]

negative regulation of lactation

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

positive regulation of MAPK cascade

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

regulation of developmental process [inference]

negative regulation of developmental process [inference]

negative regulation of lactation

regulation of multicellular organismal development [inference]

regulation of lactation [inference]

negative regulation of lactation

regulation of cellular process [inference]

signal transduction [inference]

G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-modulating G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-activating G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-activating adrenergic receptor signaling pathway

adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-inhibiting dopamine receptor signaling pathway

phospholipase C-activating G protein-coupled receptor signaling pathway [inference]

phospholipase C-activating dopamine receptor signaling pathway

adrenergic receptor signaling pathway [inference]

adenylate cyclase-activating adrenergic receptor signaling pathway

dopamine receptor signaling pathway [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

positive regulation of MAPK cascade

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

negative regulation of cell communication [inference]

negative regulation of hormone secretion [inference]

negative regulation of peptide hormone secretion [inference]

negative regulation of prolactin secretion

negative regulation of synaptic transmission [inference]

negative regulation of synaptic transmission, glutamatergic

regulation of hormone secretion [inference]

negative regulation of hormone secretion [inference]

negative regulation of peptide hormone secretion [inference]

negative regulation of prolactin secretion

regulation of peptide hormone secretion [inference]

negative regulation of peptide hormone secretion [inference]

negative regulation of prolactin secretion

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

negative regulation of synaptic transmission [inference]

negative regulation of synaptic transmission, glutamatergic

regulation of synaptic transmission, glutamatergic [inference]

negative regulation of synaptic transmission, glutamatergic

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of hormone secretion [inference]

negative regulation of peptide hormone secretion [inference]

negative regulation of prolactin secretion

negative regulation of synaptic transmission [inference]

negative regulation of synaptic transmission, glutamatergic

negative regulation of secretion by cell [inference]

negative regulation of hormone secretion [inference]

negative regulation of peptide hormone secretion [inference]

negative regulation of prolactin secretion

negative regulation of protein secretion [inference]

negative regulation of prolactin secretion

negative regulation of protein localization [inference]

negative regulation of establishment of protein localization [inference]

negative regulation of protein transport [inference]

negative regulation of protein secretion [inference]

negative regulation of prolactin secretion

regulation of cellular localization [inference]

regulation of protein localization [inference]

regulation of establishment of protein localization [inference]

regulation of protein transport [inference]

regulation of protein secretion [inference]

negative regulation of protein secretion [inference]

negative regulation of prolactin secretion

negative regulation of protein transport [inference]

negative regulation of protein secretion [inference]

negative regulation of prolactin secretion

negative regulation of establishment of protein localization [inference]

negative regulation of protein transport [inference]

negative regulation of protein secretion [inference]

negative regulation of prolactin secretion

negative regulation of protein localization [inference]

negative regulation of establishment of protein localization [inference]

negative regulation of protein transport [inference]

negative regulation of protein secretion [inference]

negative regulation of prolactin secretion

regulation of secretion by cell [inference]

regulation of hormone secretion [inference]

negative regulation of hormone secretion [inference]

negative regulation of peptide hormone secretion [inference]

negative regulation of prolactin secretion

regulation of peptide hormone secretion [inference]

negative regulation of peptide hormone secretion [inference]

negative regulation of prolactin secretion

regulation of catecholamine secretion [inference]

regulation of dopamine secretion

regulation of protein secretion [inference]

negative regulation of protein secretion [inference]

negative regulation of prolactin secretion

negative regulation of secretion by cell [inference]

negative regulation of hormone secretion [inference]

negative regulation of peptide hormone secretion [inference]

negative regulation of prolactin secretion

negative regulation of protein secretion [inference]

negative regulation of prolactin secretion

regulation of multicellular organismal process [inference]

regulation of tissue remodeling [inference]

positive regulation of tissue remodeling [inference]

positive regulation of mammary gland involution

regulation of mammary gland involution [inference]

positive regulation of mammary gland involution

positive regulation of multicellular organismal process [inference]

positive regulation of tissue remodeling [inference]

positive regulation of mammary gland involution

negative regulation of multicellular organismal process [inference]

negative regulation of lactation

regulation of multicellular organismal development [inference]

regulation of lactation [inference]

negative regulation of lactation

regulation of biological quality [inference]

regulation of hormone levels [inference]

regulation of hormone secretion [inference]

negative regulation of hormone secretion [inference]

negative regulation of peptide hormone secretion [inference]

negative regulation of prolactin secretion

regulation of peptide hormone secretion [inference]

negative regulation of peptide hormone secretion [inference]

negative regulation of prolactin secretion

regulation of body fluid levels [inference]

regulation of lactation [inference]

negative regulation of lactation

negative regulation of cytosolic calcium ion concentration

Displaying **all 4** entries
GO Term	Evidence Code	PMID
plasma membrane
Golgi membrane
presynaptic membrane	IEA	30032202
glutamatergic synapse	IEA	30032202

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

organelle membrane [inference]

bounding membrane of organelle [inference]

Golgi membrane

plasma membrane region [inference]

synaptic membrane [inference]

presynaptic membrane

cell junction [inference]

synapse [inference]

glutamatergic synapse

Displaying **all 2** entries
GO Term	Evidence Code	PMID
G protein-coupled receptor activity	IEA	22301074 30032202
dopamine neurotransmitter receptor activity, coupled via Gi/Go	IEA	30032202

GO Hierarchy

molecular function

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

G protein-coupled receptor activity

neurotransmitter receptor activity [inference]

postsynaptic neurotransmitter receptor activity [inference]

dopamine neurotransmitter receptor activity [inference]

dopamine neurotransmitter receptor activity, coupled via Gi/Go

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

receptor

Functional Category

E: Amino acid transport and metabolism
I: Lipid transport and metabolism
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
adenylate cyclase-activating adrenergic receptor signaling pathway

Displaying **all 2** entries
InterPro
G protein-coupled receptor, rhodopsin-like
GPCR, rhodopsin-like, 7TM

Ortholog

Displaying entries **11 - 20** of **106** in total

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Species	Gene ID	OrthoDB	Orthologous MAtrix
Taeniopygia guttata	100191007		TAEGU14058
Meleagris gallopavo	100303660		MELGA08135
Oryctolagus cuniculus	100347371		RABIT00605
Callithrix jacchus	100400797		CALJA05234
Pongo abelii	100442948		PONAB04029
Ailuropoda melanoleuca	100468533		AILME03320
Oreochromis niloticus	100534521		ORENI15929
Anolis carolinensis	100557445		ANOCA14907
Nomascus leucogenys	100589985		NOMLE10668
Sus scrofa	100624857	9823_0:002c0c	PIGXX35420

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Summary

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Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements