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desmocollin 1

Summary

Gene Symbol

DSC1

Organism

Bos taurus (domestic cattle)

External Links

NCBI Gene: 281127
PubChem: 281127

Annotation

Keyword

Alternative splicing
Calcium
Cell adhesion
Cell junction
Cell membrane
Cleavage on pair of basic residues
Direct protein sequencing
Glycoprotein
Metal-binding
Phosphoprotein
Reference proteome
Repeat
Signal
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
A6QR67
Q01107	Desmosomal glycoprotein 2/3

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
cell morphogenesis	IEA	30032202
sprouting angiogenesis	IEA	30032202
cell-cell junction assembly	IEA	30032202
homophilic cell adhesion via plasma membrane adhesion molecules	IEA	22301074 30032202
multicellular organism development	IEA	30032202

GO Hierarchy

biological process

cellular process [inference]

cell adhesion [inference]

cell-cell adhesion [inference]

cell-cell adhesion mediated by cadherin

cell-cell adhesion via plasma-membrane adhesion molecules [inference]

cell motility [inference]

cell migration

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

cell junction assembly [inference]

cell junction organization [inference]

cell junction assembly [inference]

cell-cell junction organization [inference]

synapse organization [inference]

synapse assembly

multicellular organismal process [inference]

multicellular organism development

developmental process [inference]

anatomical structure morphogenesis [inference]

cell morphogenesis

anatomical structure formation involved in morphogenesis [inference]

angiogenesis [inference]

sprouting angiogenesis

anatomical structure development [inference]

multicellular organism development

Displaying entries **1 - 5** of 13 in total

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GO Term	Evidence Code	PMID
cytoplasm
plasma membrane	IEA	22301074
adherens junction	IEA	30032202
postsynaptic density
intercalated disc

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

plasma membrane protein complex [inference]

catenin complex

cellular anatomical entity [inference]

cytoplasm

membrane

plasma membrane

plasma membrane region [inference]

synaptic membrane [inference]

cell junction [inference]

anchoring junction [inference]

cell-cell junction [inference]

cell-cell contact zone [inference]

intercalated disc

cell projection [inference]

plasma membrane bounded cell projection [inference]

organelle [inference]

postsynaptic specialization [inference]

postsynaptic density

apical part of cell

Displaying **all 3** entries
GO Term	Evidence Code	PMID
calcium ion binding	IEA	22301074 30032202
beta-catenin binding
cadherin binding	IEA	30032202

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

beta-catenin binding

cell adhesion molecule binding [inference]

cadherin binding

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

calcium ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

desmocollin-1

Functional Category

E: Amino acid transport and metabolism
G: Carbohydrate transport and metabolism
O: Posttranslational modification, protein turnover, chaperones

Displaying **all 8** entries
Gene Ontology
adherens junction organization
cadherin binding
calcium ion binding
calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules
cell-cell adhesion mediated by cadherin
cell-cell junction assembly
homophilic cell adhesion via plasma membrane adhesion molecules
sprouting angiogenesis

Displaying **all 8** entries
InterPro
Cadherin conserved site
Cadherin prodomain
Cadherin, Y-type LIR-motif
Cadherin-like superfamily
Cadherin-like
Cadherin
Catenin binding domain superfamily
Desmosomal cadherin

Ortholog

Displaying entries **21 - 30** of 80 in total

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Species	Gene ID	Orthologous MAtrix
Loxodonta africana	100675635	LOXAF18528
Oreochromis niloticus	100707499	ORENI29524
Cavia porcellus	100713397	CAVPO08195
Cricetulus griseus	100762663	CRIGR21400
Pan paniscus	100995730	PANPA18525
Papio anubis	101023960	PAPAN16928
Takifugu rubripes	101064516	TAKRU32783
Felis catus	101083463	FELCA27659
Ovis aries	101115748	SHEEP11841
Gorilla gorilla gorilla	101150337	GORGO14219