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sphingosine-1-phosphate receptor 1

Summary

Gene Symbol

S1PR1

Organism

Bos taurus (domestic cattle)

External Links

NCBI Gene: 281135
PubChem: 281135

Annotation

Keyword

Acetylation
Angiogenesis
Cell membrane
Chemotaxis
Disulfide bond
Endosome
G-protein coupled receptor
Glycoprotein
Palmitate
Phosphoprotein
Reference proteome
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q5E9P3	Endothelial differentiation G-protein coupled receptor 1 Sphingosine 1-phosphate receptor Edg-1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **6 - 10** of 14 in total

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GO Term	Evidence Code	PMID
regulation of metabolic process
cell migration
T cell migration
cardiac muscle tissue growth involved in heart morphogenesis
regulation of bone resorption

GO Hierarchy

biological process

immune system process [inference]

leukocyte migration [inference]

mononuclear cell migration [inference]

lymphocyte migration [inference]

T cell migration

cellular process [inference]

signal transduction [inference]

G protein-coupled receptor signaling pathway [inference]

sphingosine-1-phosphate receptor signaling pathway

adenylate cyclase-modulating G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-activating G protein-coupled receptor signaling pathway

sphingolipid mediated signaling pathway [inference]

sphingosine-1-phosphate receptor signaling pathway

actin filament-based process [inference]

actin cytoskeleton organization

cell motility [inference]

cell migration

leukocyte migration [inference]

mononuclear cell migration [inference]

lymphocyte migration [inference]

T cell migration

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

cytoskeleton organization [inference]

actin cytoskeleton organization

cellular component assembly [inference]

cell projection assembly [inference]

plasma membrane bounded cell projection assembly [inference]

lamellipodium assembly

cell projection organization [inference]

cell projection assembly [inference]

plasma membrane bounded cell projection assembly [inference]

lamellipodium assembly

plasma membrane bounded cell projection organization [inference]

lamellipodium organization [inference]

lamellipodium assembly

plasma membrane bounded cell projection assembly [inference]

lamellipodium assembly

developmental process [inference]

anatomical structure morphogenesis [inference]

trabecula morphogenesis [inference]

heart trabecula morphogenesis

developmental maturation [inference]

anatomical structure maturation [inference]

blood vessel maturation

anatomical structure formation involved in morphogenesis [inference]

angiogenesis

growth [inference]

developmental growth [inference]

cardiac muscle tissue growth [inference]

cardiac muscle tissue growth involved in heart morphogenesis

developmental growth involved in morphogenesis [inference]

growth involved in heart morphogenesis [inference]

cardiac muscle tissue growth involved in heart morphogenesis

locomotion [inference]

taxis [inference]

chemotaxis

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process

regulation of developmental process [inference]

regulation of multicellular organismal development [inference]

regulation of biomineral tissue development [inference]

regulation of bone mineralization

regulation of cellular process [inference]

signal transduction [inference]

G protein-coupled receptor signaling pathway [inference]

sphingosine-1-phosphate receptor signaling pathway

adenylate cyclase-modulating G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-activating G protein-coupled receptor signaling pathway

sphingolipid mediated signaling pathway [inference]

sphingosine-1-phosphate receptor signaling pathway

regulation of multicellular organismal process [inference]

regulation of ossification [inference]

regulation of bone mineralization

regulation of tissue remodeling [inference]

regulation of bone remodeling [inference]

regulation of bone resorption

regulation of multicellular organismal development [inference]

regulation of biomineral tissue development [inference]

regulation of bone mineralization

Displaying **all 5** entries
GO Term	Evidence Code	PMID
membrane	IEA	22301074
plasma membrane
membrane raft
endosome
cytoplasm

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytoplasm

membrane

plasma membrane

membrane microdomain [inference]

membrane raft

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

Displaying 1 entry
GO Term	Evidence Code	PMID
sphingosine-1-phosphate receptor activity	IEA	22301074 30032202

GO Hierarchy

molecular function

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

G protein-coupled receptor activity [inference]

bioactive lipid receptor activity [inference]

sphingosine-1-phosphate receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

sphingosine 1-phosphate receptor 1

Functional Category

G: Carbohydrate transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 3** entries
Gene Ontology
angiogenesis
chemotaxis
sphingosine-1-phosphate receptor activity

Displaying **all 4** entries
InterPro
G protein-coupled receptor, rhodopsin-like
GPCR, rhodopsin-like, 7TM
Sphingosine 1-phosphate receptor 1
Sphingosine 1-phosphate receptor

Ortholog

Displaying entries **51 - 60** of **104** in total

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Species	Gene ID	OrthoDB	Orthologous MAtrix
Chlorocebus sabaeus	103224354		CHLSB08640
Nannospalax galili	103741878		NANGA22198
Serinus canaria	103814856		SERCA08160
Rhinopithecus roxellana	104660302		RHIRO33182
Bison bison bison	104981718	43346_0:004e08
Camelus bactrianus	105065364	9837_0:0013e0
Camelus dromedarius	105084879	9838_0:001768
Pteropus vampyrus	105297525		PTEVA08439
Macaca nemestrina	105485479		MACNE30480
Mandrillus leucophaeus	105548509		MANLE25947

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Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements