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sphingosine-1-phosphate receptor 1

Summary

Gene Symbol

S1PR1

Organism

Bos taurus (domestic cattle)

External Links

NCBI Gene: 281135
PubChem: 281135

Annotation

Keyword

Acetylation
Angiogenesis
Cell membrane
Chemotaxis
Disulfide bond
Endosome
G-protein coupled receptor
Glycoprotein
Palmitate
Phosphoprotein
Reference proteome
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q5E9P3	Endothelial differentiation G-protein coupled receptor 1 Sphingosine 1-phosphate receptor Edg-1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **11 - 14** of 14 in total

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GO Term	Evidence Code	PMID
blood vessel maturation
sphingosine-1-phosphate receptor signaling pathway	IEA	30032202
angiogenesis	IEA	30032202
adenylate cyclase-activating G protein-coupled receptor signaling pathway

GO Hierarchy

biological process

immune system process [inference]

leukocyte migration [inference]

mononuclear cell migration [inference]

lymphocyte migration [inference]

T cell migration

cellular process [inference]

signal transduction [inference]

G protein-coupled receptor signaling pathway [inference]

sphingosine-1-phosphate receptor signaling pathway

adenylate cyclase-modulating G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-activating G protein-coupled receptor signaling pathway

sphingolipid mediated signaling pathway [inference]

sphingosine-1-phosphate receptor signaling pathway

actin filament-based process [inference]

actin cytoskeleton organization

cell motility [inference]

cell migration

leukocyte migration [inference]

mononuclear cell migration [inference]

lymphocyte migration [inference]

T cell migration

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

cytoskeleton organization [inference]

actin cytoskeleton organization

cellular component assembly [inference]

cell projection assembly [inference]

plasma membrane bounded cell projection assembly [inference]

lamellipodium assembly

cell projection organization [inference]

cell projection assembly [inference]

plasma membrane bounded cell projection assembly [inference]

lamellipodium assembly

plasma membrane bounded cell projection organization [inference]

lamellipodium organization [inference]

lamellipodium assembly

plasma membrane bounded cell projection assembly [inference]

lamellipodium assembly

developmental process [inference]

anatomical structure morphogenesis [inference]

trabecula morphogenesis [inference]

heart trabecula morphogenesis

developmental maturation [inference]

anatomical structure maturation [inference]

blood vessel maturation

anatomical structure formation involved in morphogenesis [inference]

angiogenesis

growth [inference]

developmental growth [inference]

cardiac muscle tissue growth [inference]

cardiac muscle tissue growth involved in heart morphogenesis

developmental growth involved in morphogenesis [inference]

growth involved in heart morphogenesis [inference]

cardiac muscle tissue growth involved in heart morphogenesis

locomotion [inference]

taxis [inference]

chemotaxis

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process

regulation of developmental process [inference]

regulation of multicellular organismal development [inference]

regulation of biomineral tissue development [inference]

regulation of bone mineralization

regulation of cellular process [inference]

signal transduction [inference]

G protein-coupled receptor signaling pathway [inference]

sphingosine-1-phosphate receptor signaling pathway

adenylate cyclase-modulating G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-activating G protein-coupled receptor signaling pathway

sphingolipid mediated signaling pathway [inference]

sphingosine-1-phosphate receptor signaling pathway

regulation of multicellular organismal process [inference]

regulation of ossification [inference]

regulation of bone mineralization

regulation of tissue remodeling [inference]

regulation of bone remodeling [inference]

regulation of bone resorption

regulation of multicellular organismal development [inference]

regulation of biomineral tissue development [inference]

regulation of bone mineralization

Displaying **all 5** entries
GO Term	Evidence Code	PMID
membrane	IEA	22301074
plasma membrane
membrane raft
endosome
cytoplasm

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytoplasm

membrane

plasma membrane

membrane microdomain [inference]

membrane raft

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

Displaying 1 entry
GO Term	Evidence Code	PMID
sphingosine-1-phosphate receptor activity	IEA	22301074 30032202

GO Hierarchy

molecular function

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

G protein-coupled receptor activity [inference]

bioactive lipid receptor activity [inference]

sphingosine-1-phosphate receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

sphingosine 1-phosphate receptor 1

Functional Category

G: Carbohydrate transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 3** entries
Gene Ontology
angiogenesis
chemotaxis
sphingosine-1-phosphate receptor activity

Displaying **all 4** entries
InterPro
G protein-coupled receptor, rhodopsin-like
GPCR, rhodopsin-like, 7TM
Sphingosine 1-phosphate receptor 1
Sphingosine 1-phosphate receptor

Ortholog

Displaying entries **31 - 40** of **104** in total

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Species	Gene ID	OrthoDB	Orthologous MAtrix
Mustela putorius furo	101681508		MUSPF03688
Heterocephalus glaber	101697978		HETGA04966
Ficedula albicollis	101821933		FICAL04171
Melopsittacus undulatus	101868792		MELUD19628
Ictidomys tridecemlineatus	101970880		ICTTR04001
Chinchilla lanigera	102008975		CHILA09686
Macaca fascicularis	102127318		MACFA21770
Capra hircus	102172679	9925_0:00096d	CAPHI22171
Bos mutus	102266604	72004_1:003db6
Latimeria chalumnae	102345178		LATCH03561

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Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements