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glutathione peroxidase 1

Summary

Gene Symbol

GPX1

Organism

Bos taurus (domestic cattle)

External Links

NCBI Gene: 281209
KEGG Gene ID: bta:281209
PubChem: 281209

Annotation

Keyword

3D-structure
Acetylation
Cytoplasm
Direct protein sequencing
Glycation
Lipid metabolism
Mitochondrion
Peroxidase
Phosphoprotein
Reference proteome
Selenocysteine

Proteins

Displaying 1 entry
UniProt	Protein Name
P00435	Cellular glutathione peroxidase Phospholipid-hydroperoxide glutathione peroxidase GPX1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
glutathione metabolic process	IEA	30032202
response to selenium ion	IEA	30032202
arachidonic acid metabolic process
lipoxygenase pathway
response to hydrogen peroxide	IEA	30032202

GO Hierarchy

biological process

metabolic process [inference]

catabolic process [inference]

cellular catabolic process [inference]

hydrogen peroxide catabolic process

organic substance catabolic process [inference]

hydrogen peroxide catabolic process

cellular metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

icosanoid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

arachidonic acid metabolic process

lipoxygenase pathway

unsaturated fatty acid metabolic process [inference]

arachidonic acid metabolic process

cellular catabolic process [inference]

hydrogen peroxide catabolic process

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

arachidonic acid metabolic process

lipoxygenase pathway

unsaturated fatty acid metabolic process [inference]

arachidonic acid metabolic process

reactive oxygen species metabolic process [inference]

hydrogen peroxide metabolic process [inference]

hydrogen peroxide catabolic process

primary metabolic process [inference]

lipid metabolic process [inference]

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

arachidonic acid metabolic process

lipoxygenase pathway

unsaturated fatty acid metabolic process [inference]

arachidonic acid metabolic process

small molecule metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

icosanoid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

arachidonic acid metabolic process

lipoxygenase pathway

unsaturated fatty acid metabolic process [inference]

arachidonic acid metabolic process

organic substance metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

icosanoid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

arachidonic acid metabolic process

lipoxygenase pathway

unsaturated fatty acid metabolic process [inference]

arachidonic acid metabolic process

lipid metabolic process [inference]

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

arachidonic acid metabolic process

lipoxygenase pathway

unsaturated fatty acid metabolic process [inference]

arachidonic acid metabolic process

glutathione metabolic process

hydrogen peroxide metabolic process [inference]

hydrogen peroxide catabolic process

olefinic compound metabolic process [inference]

arachidonic acid metabolic process

organic substance catabolic process [inference]

hydrogen peroxide catabolic process

cellular process [inference]

cellular metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

icosanoid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

arachidonic acid metabolic process

lipoxygenase pathway

unsaturated fatty acid metabolic process [inference]

arachidonic acid metabolic process

cellular catabolic process [inference]

hydrogen peroxide catabolic process

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

arachidonic acid metabolic process

lipoxygenase pathway

unsaturated fatty acid metabolic process [inference]

arachidonic acid metabolic process

reactive oxygen species metabolic process [inference]

hydrogen peroxide metabolic process [inference]

hydrogen peroxide catabolic process

response to stimulus [inference]

response to stress [inference]

response to oxidative stress [inference]

response to reactive oxygen species [inference]

response to hydrogen peroxide

response to chemical [inference]

response to organic substance [inference]

response to hydrogen peroxide

response to inorganic substance [inference]

response to oxygen-containing compound [inference]

response to reactive oxygen species [inference]

response to hydrogen peroxide

biological regulation [inference]

regulation of biological process [inference]

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cellular component organization [inference]

positive regulation of supramolecular fiber organization

regulation of cellular process [inference]

positive regulation of cellular process [inference]

positive regulation of cellular component organization [inference]

positive regulation of supramolecular fiber organization

regulation of cellular component organization [inference]

positive regulation of cellular component organization [inference]

positive regulation of supramolecular fiber organization

regulation of supramolecular fiber organization [inference]

positive regulation of supramolecular fiber organization

Displaying **all 2** entries
GO Term	Evidence Code	PMID
mitochondrion	IEA	30032202
cytosol	IEA	30032202

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytosol

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

Displaying **all 2** entries
GO Term	Evidence Code	PMID
glutathione peroxidase activity	IEA	22301074 30032202
phospholipid-hydroperoxide glutathione peroxidase activity

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

oxidoreductase activity, acting on peroxide as acceptor [inference]

peroxidase activity [inference]

antioxidant activity [inference]

peroxidase activity [inference]

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Glutathione peroxidase

Functional Category

E: Amino acid transport and metabolism
I: Lipid transport and metabolism
V: Defense mechanisms

Displaying **all 3** entries
Gene Ontology
cellular oxidant detoxification
oxidoreductase activity
response to oxidative stress

Displaying **all 3** entries
InterPro
Glutathione peroxidase conserved site
Glutathione peroxidase
Thioredoxin-like superfamily

KEGG BRITE Database

Orthology

K00432

Name

glutathione peroxidase [EC:1.11.1.9]

References

3408482

Rhea

RHEA:16833

H₂O₂ + glutathione

H₂O + glutathione disulfide

Enzyme

1.11.1.9

PMID

RHEA:19057

a hydroperoxy polyunsaturated fatty acid + glutathione

a hydroxy polyunsaturated fatty acid + H₂O + glutathione disulfide

Enzyme

1.11.1.12

PMID

Ortholog

Displaying entries **1 - 10** of 34 in total

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Species	Gene ID	Orthologous MAtrix
Homo sapiens	2876	HUMAN70021
Mus musculus	14775	MOUSE62161
Rattus norvegicus	24404	RATNO41946
Sus scrofa	397403	PIGXX04077
Pan troglodytes	461015	PANTR31133
Macaca mulatta	706732	MACMU29604
Callithrix jacchus	100392863	CALJA11684
Pongo abelii	100438450	PONAB25996
Monodelphis domestica	100619791	MONDO30537
Cavia porcellus	100728835	CAVPO04986