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palmitoyl-protein thioesterase 1

Summary

Gene Symbol

PPT1

Organism

Bos taurus (domestic cattle)

External Links

NCBI Gene: 281421
KEGG Gene ID: bta:281421
PubChem: 281421

Annotation

Keyword

3D-structure
Direct protein sequencing
Disulfide bond
Glycoprotein
Hydrolase
Lysosome
Reference proteome
Secreted
Signal

Proteins

Displaying 1 entry
UniProt	Protein Name
P45478	Palmitoyl-protein hydrolase 1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 14 in total

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GO Term	Evidence Code	PMID
protein depalmitoylation	IEA	30032202
receptor-mediated endocytosis	IEA	30032202
pinocytosis
lysosomal lumen acidification
nervous system development	IEA	30032202

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein catabolic process [inference]

lipoprotein catabolic process [inference]

protein depalmitoylation

protein modification process [inference]

protein deacylation [inference]

protein depalmitoylation

lipoprotein metabolic process [inference]

lipoprotein catabolic process [inference]

protein depalmitoylation

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

lipoprotein catabolic process [inference]

protein depalmitoylation

catabolic process [inference]

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

lipoprotein catabolic process [inference]

protein depalmitoylation

lipid catabolic process

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

lipoprotein catabolic process [inference]

protein depalmitoylation

primary metabolic process [inference]

lipid metabolic process [inference]

lipid catabolic process

protein metabolic process [inference]

protein catabolic process [inference]

lipoprotein catabolic process [inference]

protein depalmitoylation

protein modification process [inference]

protein deacylation [inference]

protein depalmitoylation

lipoprotein metabolic process [inference]

lipoprotein catabolic process [inference]

protein depalmitoylation

organic substance metabolic process [inference]

lipid metabolic process [inference]

lipid catabolic process

macromolecule metabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

lipoprotein catabolic process [inference]

protein depalmitoylation

protein metabolic process [inference]

protein catabolic process [inference]

lipoprotein catabolic process [inference]

protein depalmitoylation

protein modification process [inference]

protein deacylation [inference]

protein depalmitoylation

lipoprotein metabolic process [inference]

lipoprotein catabolic process [inference]

protein depalmitoylation

macromolecule modification [inference]

protein modification process [inference]

protein deacylation [inference]

protein depalmitoylation

macromolecule deacylation [inference]

protein deacylation [inference]

protein depalmitoylation

macromolecule depalmitoylation [inference]

protein depalmitoylation

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein catabolic process [inference]

lipoprotein catabolic process [inference]

protein depalmitoylation

protein modification process [inference]

protein deacylation [inference]

protein depalmitoylation

lipoprotein metabolic process [inference]

lipoprotein catabolic process [inference]

protein depalmitoylation

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

lipoprotein catabolic process [inference]

protein depalmitoylation

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

lipoprotein catabolic process [inference]

protein depalmitoylation

lipid catabolic process

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

lipoprotein catabolic process [inference]

protein depalmitoylation

cellular process [inference]

vesicle-mediated transport [inference]

endocytosis [inference]

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport

cellular component organization or biogenesis [inference]

cellular component organization [inference]

membrane organization [inference]

membrane raft organization

developmental process [inference]

anatomical structure development [inference]

animal organ development [inference]

brain development

system development [inference]

nervous system development

homeostatic process [inference]

cellular homeostasis [inference]

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

regulation of cellular pH [inference]

regulation of intracellular pH [inference]

regulation of lysosomal lumen pH [inference]

lysosomal lumen acidification

intracellular pH reduction [inference]

vacuolar acidification [inference]

lysosomal lumen acidification

chemical homeostasis [inference]

monoatomic ion homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

regulation of cellular pH [inference]

regulation of intracellular pH [inference]

regulation of lysosomal lumen pH [inference]

lysosomal lumen acidification

intracellular pH reduction [inference]

vacuolar acidification [inference]

lysosomal lumen acidification

monoatomic cation homeostasis [inference]

regulation of pH [inference]

regulation of cellular pH [inference]

regulation of intracellular pH [inference]

regulation of lysosomal lumen pH [inference]

lysosomal lumen acidification

intracellular pH reduction [inference]

vacuolar acidification [inference]

lysosomal lumen acidification

intracellular monoatomic cation homeostasis [inference]

regulation of cellular pH [inference]

regulation of intracellular pH [inference]

regulation of lysosomal lumen pH [inference]

lysosomal lumen acidification

intracellular pH reduction [inference]

vacuolar acidification [inference]

lysosomal lumen acidification

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

regulation of cellular pH [inference]

regulation of intracellular pH [inference]

regulation of lysosomal lumen pH [inference]

lysosomal lumen acidification

intracellular pH reduction [inference]

vacuolar acidification [inference]

lysosomal lumen acidification

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport

establishment of localization [inference]

transport [inference]

vesicle-mediated transport [inference]

endocytosis [inference]

organic substance transport [inference]

protein transport

nitrogen compound transport [inference]

protein transport

import into cell [inference]

endocytosis [inference]

establishment of protein localization [inference]

protein transport

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport

biological regulation [inference]

regulation of pH [inference]

regulation of cellular pH [inference]

regulation of intracellular pH [inference]

regulation of lysosomal lumen pH [inference]

lysosomal lumen acidification

intracellular pH reduction [inference]

vacuolar acidification [inference]

lysosomal lumen acidification

regulation of biological process [inference]

regulation of localization [inference]

regulation of transport [inference]

positive regulation of transport [inference]

positive regulation of endocytosis [inference]

regulation of vesicle-mediated transport [inference]

regulation of endocytosis [inference]

positive regulation of endocytosis [inference]

regulation of receptor-mediated endocytosis [inference]

positive regulation of receptor-mediated endocytosis

regulation of pinocytosis [inference]

positive regulation of pinocytosis

regulation of growth [inference]

regulation of cell growth [inference]

negative regulation of cell growth

negative regulation of growth [inference]

negative regulation of cell growth

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cellular component organization [inference]

positive regulation of endocytosis [inference]

positive regulation of transport [inference]

positive regulation of endocytosis [inference]

negative regulation of biological process [inference]

negative regulation of growth [inference]

negative regulation of cell growth

negative regulation of cellular process [inference]

negative regulation of cell growth

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

negative regulation of neuron apoptotic process

regulation of cellular process [inference]

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

negative regulation of apoptotic process

negative regulation of neuron apoptotic process

regulation of neuron apoptotic process [inference]

negative regulation of neuron apoptotic process

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

negative regulation of neuron apoptotic process

positive regulation of cellular process [inference]

positive regulation of cellular component organization [inference]

positive regulation of endocytosis [inference]

negative regulation of cellular process [inference]

negative regulation of cell growth

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

negative regulation of neuron apoptotic process

regulation of cellular component organization [inference]

regulation of cell growth [inference]

negative regulation of cell growth

regulation of endocytosis [inference]

positive regulation of endocytosis [inference]

regulation of receptor-mediated endocytosis [inference]

positive regulation of receptor-mediated endocytosis

regulation of pinocytosis [inference]

positive regulation of pinocytosis

positive regulation of cellular component organization [inference]

positive regulation of endocytosis [inference]

regulation of vesicle-mediated transport [inference]

regulation of endocytosis [inference]

positive regulation of endocytosis [inference]

regulation of receptor-mediated endocytosis [inference]

positive regulation of receptor-mediated endocytosis

regulation of pinocytosis [inference]

positive regulation of pinocytosis

regulation of biological quality [inference]

regulation of intracellular pH [inference]

regulation of lysosomal lumen pH [inference]

lysosomal lumen acidification

intracellular pH reduction [inference]

vacuolar acidification [inference]

lysosomal lumen acidification

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
extracellular region
nucleus
lysosome	IEA	30032202
Golgi apparatus
cytosol

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

membrane microdomain [inference]

membrane raft

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

axon

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

transport vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

secretory vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

intracellular membrane-bounded organelle [inference]

nucleus

vacuole [inference]

lytic vacuole [inference]

lysosome

Golgi apparatus

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

transport vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

secretory vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

vacuole [inference]

lytic vacuole [inference]

lysosome

Golgi apparatus

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

transport vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

secretory vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

Displaying **all 3** entries
GO Term	Evidence Code	PMID
palmitoyl-(protein) hydrolase activity	IEA	30032202
long-chain acyl-CoA hydrolase activity
sulfatide binding

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on ester bonds [inference]

thiolester hydrolase activity [inference]

palmitoyl-(protein) hydrolase activity

CoA hydrolase activity [inference]

acyl-CoA hydrolase activity [inference]

long-chain acyl-CoA hydrolase activity

palmitoyl hydrolase activity [inference]

palmitoyl-(protein) hydrolase activity

catalytic activity, acting on a protein [inference]

palmitoyl-(protein) hydrolase activity

binding [inference]

lipid binding [inference]

glycolipid binding [inference]

sulfatide binding

carbohydrate derivative binding [inference]

glycolipid binding [inference]

sulfatide binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

palmitoyl protein

Functional Category

G: Carbohydrate transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 6** entries
Gene Ontology
hydrolase activity
macromolecule depalmitoylation
nervous system development
palmitoyl hydrolase activity
palmitoyl-(protein) hydrolase activity
receptor-mediated endocytosis

Displaying **all 2** entries
InterPro
Alpha/Beta hydrolase fold
Palmitoyl protein thioesterase

Rhea

RHEA:19233

H₂O

H⁺ + hexadecanoate

Enzyme

3.1.2.22

PMID

Ortholog

Displaying entries **1 - 10** of 84 in total

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Species	Gene ID	Orthologous MAtrix
Homo sapiens	5538	HUMAN49061
Mus musculus	19063	MOUSE41762
Rattus norvegicus	29411	RATNO34701
Danio rerio	406648	DANRE16023
Pan troglodytes	456789	PANTR20750
Canis lupus familiaris	475316	CANLF03912
Macaca mulatta	693377	MACMU21827
Monodelphis domestica	100032080	MONDO22911
Ornithorhynchus anatinus	100077897	ORNAN08375
Pongo abelii	100174770	PONAB17049

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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OrthoDB (Group)

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Acknowledgements