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prosaposin

Summary

Gene Symbol

PSAP

Organism

Bos taurus (domestic cattle)

External Links

NCBI Gene: 281433
KEGG Gene ID: bta:281433
PubChem: 281433

Annotation

Keyword

Alternative splicing
Cleavage on pair of basic residues
Direct protein sequencing
Disulfide bond
Glycoprotein
Lysosome
Reference proteome
Repeat
Secreted
Signal
Sphingolipid metabolism

Proteins

Displaying 1 entry
UniProt	Protein Name
P26779	Proactivator polypeptide

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
sphingolipid metabolic process	IEA	22301074
lysosomal transport
adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	IEA	30032202
regulation of lipid metabolic process	IEA	30032202
prostate gland growth	IEA	30032202

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

sphingolipid metabolic process

cellular metabolic process [inference]

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

sphingolipid metabolic process

primary metabolic process [inference]

lipid metabolic process [inference]

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

sphingolipid metabolic process

organic substance metabolic process [inference]

lipid metabolic process [inference]

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

sphingolipid metabolic process

organonitrogen compound metabolic process [inference]

sphingolipid metabolic process

cellular process [inference]

signal transduction [inference]

G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-modulating G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway

cellular metabolic process [inference]

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

sphingolipid metabolic process

cellular developmental process [inference]

cell differentiation [inference]

epithelial cell differentiation [inference]

epithelial cell differentiation involved in prostate gland development

cellular localization [inference]

intracellular transport [inference]

vacuolar transport [inference]

lysosomal transport

reproductive process [inference]

developmental process involved in reproduction [inference]

multicellular organismal process [inference]

organ growth [inference]

prostate gland growth

developmental process [inference]

developmental process involved in reproduction [inference]

cellular developmental process [inference]

cell differentiation [inference]

epithelial cell differentiation [inference]

epithelial cell differentiation involved in prostate gland development

growth [inference]

developmental growth [inference]

organ growth [inference]

prostate gland growth

localization [inference]

establishment of localization [inference]

transport [inference]

intracellular transport [inference]

vacuolar transport [inference]

lysosomal transport

establishment of localization in cell [inference]

intracellular transport [inference]

vacuolar transport [inference]

lysosomal transport

cellular localization [inference]

intracellular transport [inference]

vacuolar transport [inference]

lysosomal transport

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of primary metabolic process [inference]

regulation of lipid metabolic process

regulation of cellular process [inference]

signal transduction [inference]

G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-modulating G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway

Displaying **all 3** entries
GO Term	Evidence Code	PMID
extracellular region
lysosome	IEA	22301074 30032202
late endosome

GO Hierarchy

cellular component

cellular anatomical entity [inference]

extracellular region

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

late endosome

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

late endosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

late endosome

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

prosaposin

Functional Category

J: Translation, ribosomal structure and biogenesis
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 6** entries
Gene Ontology
adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
epithelial cell differentiation involved in prostate gland development
lipid metabolic process
prostate gland growth
regulation of lipid metabolic process
sphingolipid metabolic process

Displaying **all 6** entries
InterPro
Saposin A-type domain
Saposin B type domain
Saposin B type, region 2
Saposin-like type B, region 1
Saposin-like
Saposin

KEGG BRITE Database

Orthology

K12382

Name

saposin

References

Ortholog

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Species	Gene ID	Orthologous MAtrix
Mus musculus	19156	MOUSE01547
Rattus norvegicus	25524	RATNO22029
Danio rerio	140811	DANRE05749
Pan troglodytes	450517	PANTR00849
Canis lupus familiaris	479240	CANLF14657
Macaca mulatta	709510	MACMU46394
Equus caballus	100063520	HORSE18018
Ornithorhynchus anatinus	100077317	ORNAN18122
Ovis aries	100135695	SHEEP12871
Sus scrofa	100153167	PIGXX07770

GlyTouCan

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UniCarb-DR

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Annotation

OrthoDB (Group)

KEGG BRITE Database

International Collaboration

Acknowledgements