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thrombospondin 1

Summary

Gene Symbol

THBS1

Organism

Bos taurus (domestic cattle)

External Links

NCBI Gene: 281530
PubChem: 281530

Annotation

Keyword

Calcium
Cell adhesion
Disulfide bond
EGF-like domain
Endoplasmic reticulum
Extracellular matrix
Glycoprotein
Heparin-binding
Reference proteome
Repeat
Sarcoplasmic reticulum
Signal
Unfolded protein response

Proteins

Displaying 1 entry
UniProt	Protein Name
Q28178	Glycoprotein G

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 5** entries
GO Term	Evidence Code	PMID
response to unfolded protein
cell adhesion	IEA	22301074
negative regulation of angiogenesis	IEA	30032202
response to endoplasmic reticulum stress
behavioral response to pain

GO Hierarchy

biological process

cellular process [inference]

cell adhesion

cellular response to stimulus [inference]

cellular response to stress [inference]

response to endoplasmic reticulum stress

multicellular organismal process [inference]

behavior [inference]

behavioral response to pain

response to stimulus [inference]

response to stress [inference]

cellular response to stress [inference]

response to endoplasmic reticulum stress

response to topologically incorrect protein [inference]

response to unfolded protein

response to chemical [inference]

response to organic substance [inference]

response to topologically incorrect protein [inference]

response to unfolded protein

cellular response to stimulus [inference]

cellular response to stress [inference]

response to endoplasmic reticulum stress

biological regulation [inference]

regulation of biological process [inference]

negative regulation of biological process [inference]

negative regulation of developmental process [inference]

negative regulation of vasculature development [inference]

negative regulation of blood vessel morphogenesis [inference]

negative regulation of angiogenesis

negative regulation of multicellular organismal process [inference]

negative regulation of vasculature development [inference]

negative regulation of blood vessel morphogenesis [inference]

negative regulation of angiogenesis

regulation of developmental process [inference]

regulation of anatomical structure morphogenesis [inference]

regulation of angiogenesis [inference]

negative regulation of angiogenesis

negative regulation of blood vessel morphogenesis [inference]

negative regulation of angiogenesis

negative regulation of developmental process [inference]

negative regulation of vasculature development [inference]

negative regulation of blood vessel morphogenesis [inference]

negative regulation of angiogenesis

regulation of multicellular organismal development [inference]

regulation of vasculature development [inference]

regulation of angiogenesis [inference]

negative regulation of angiogenesis

negative regulation of vasculature development [inference]

negative regulation of blood vessel morphogenesis [inference]

negative regulation of angiogenesis

regulation of multicellular organismal process [inference]

negative regulation of multicellular organismal process [inference]

negative regulation of vasculature development [inference]

negative regulation of blood vessel morphogenesis [inference]

negative regulation of angiogenesis

regulation of multicellular organismal development [inference]

regulation of vasculature development [inference]

regulation of angiogenesis [inference]

negative regulation of angiogenesis

negative regulation of vasculature development [inference]

negative regulation of blood vessel morphogenesis [inference]

negative regulation of angiogenesis

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
extracellular region	IEA	22301074
endoplasmic reticulum
cell surface
sarcoplasmic reticulum
extracellular matrix

GO Hierarchy

cellular component

cellular anatomical entity [inference]

external encapsulating structure [inference]

extracellular matrix

collagen-containing extracellular matrix

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

sarcoplasmic reticulum

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

sarcoplasmic reticulum

Displaying **all 4** entries
GO Term	Evidence Code	PMID
fibronectin binding
calcium ion binding	IEA	22301074
protein binding	IEA	22301074
heparin binding

GO Hierarchy

molecular function

binding [inference]

protein binding

fibronectin binding

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

calcium ion binding

carbohydrate derivative binding [inference]

glycosaminoglycan binding [inference]

heparin binding

sulfur compound binding [inference]

heparin binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

thrombospondin-1

Functional Category

I: Lipid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 3** entries
Gene Ontology
calcium ion binding
heparin binding
negative regulation of angiogenesis

Displaying entries **1 - 10** of 12 in total

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InterPro
Concanavalin A-like lectin/glucanase domain superfamily
EGF domain
EGF-like calcium-binding domain
EGF-like domain
TSP type-3 repeat
Thrombospondin type-1 (TSP1) repeat superfamily
Thrombospondin type-1 (TSP1) repeat
Thrombospondin, C-terminal
Thrombospondin, type 3 repeat
Thrombospondin, type 3-like repeat

Ortholog

Displaying entries **1 - 10** of **126** in total

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Species	Gene ID	Orthologous MAtrix
Homo sapiens	7057	HUMAN22223
Mus musculus	21825	MOUSE35698
Rattus norvegicus	445442	RATNO26188
Pan troglodytes	453319	PANTR09946
Sus scrofa	492313	PIGXX14650
Danio rerio	561901	DANRE19137
Ciona intestinalis	619278	CIOIN07187
Macaca mulatta	705413	MACMU42235
Monodelphis domestica	100031767	MONDO05302
Equus caballus	100057478	HORSE17434