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ATP binding cassette subfamily C member 1

Summary

Gene Symbol

ABCC1

Organism

Bos taurus (domestic cattle)

External Links

NCBI Gene: 281588
PubChem: 281588

Annotation

Keyword

3D-structure
ATP-binding
Cell membrane
Glycoprotein
Hydrolase
Lipid transport
Phosphoprotein
Reference proteome
Repeat
Translocase
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q8HXQ5	ATP-binding cassette sub-family C member 1 Glutathione-S-conjugate-translocating ATPase ABCC1 Leukotriene C(4) transporter

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
lipid transport
response to xenobiotic stimulus
glutathione transmembrane transport	IEA	30032202
xenobiotic transport	IEA	30032202
positive regulation of inflammatory response

GO Hierarchy

biological process

cellular process [inference]

transmembrane transport [inference]

glutathione transmembrane transport

response to stimulus [inference]

response to chemical [inference]

response to xenobiotic stimulus

localization [inference]

establishment of localization [inference]

transport [inference]

xenobiotic transport

transmembrane transport [inference]

glutathione transmembrane transport

organic substance transport [inference]

lipid transport

organic anion transport [inference]

glutathione transport [inference]

glutathione transmembrane transport

carboxylic acid transport [inference]

icosanoid transport [inference]

leukotriene transport

organophosphate ester transport [inference]

nucleotide transport [inference]

cyclic nucleotide transport

organic acid transport [inference]

carboxylic acid transport [inference]

icosanoid transport [inference]

leukotriene transport

nucleobase-containing compound transport [inference]

nucleotide transport [inference]

cyclic nucleotide transport

nitrogen compound transport [inference]

nucleobase-containing compound transport [inference]

nucleotide transport [inference]

cyclic nucleotide transport

biological regulation [inference]

regulation of biological process [inference]

positive regulation of biological process [inference]

positive regulation of response to stimulus [inference]

positive regulation of defense response [inference]

positive regulation of inflammatory response

positive regulation of response to external stimulus [inference]

positive regulation of inflammatory response

regulation of response to stimulus [inference]

regulation of response to external stimulus [inference]

positive regulation of response to external stimulus [inference]

positive regulation of inflammatory response

regulation of inflammatory response [inference]

positive regulation of inflammatory response

positive regulation of response to stimulus [inference]

positive regulation of defense response [inference]

positive regulation of inflammatory response

positive regulation of response to external stimulus [inference]

positive regulation of inflammatory response

regulation of response to stress [inference]

regulation of defense response [inference]

positive regulation of defense response [inference]

positive regulation of inflammatory response

regulation of inflammatory response [inference]

positive regulation of inflammatory response

Displaying 1 entry
GO Term	Evidence Code	PMID
basolateral plasma membrane	IEA	30032202

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane region [inference]

basolateral plasma membrane

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GO Term	Evidence Code	PMID
ATP binding	IEA	22301074
ABC-type xenobiotic transporter activity	IEA	30032202
ABC-type glutathione S-conjugate transporter activity
ATP hydrolysis activity	IEA	22301074
glutathione transmembrane transporter activity	IEA	30032202

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on acid anhydrides [inference]

hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [inference]

pyrophosphatase activity [inference]

ribonucleoside triphosphate phosphatase activity [inference]

ATP hydrolysis activity

transporter activity [inference]

transmembrane transporter activity [inference]

organic anion transmembrane transporter activity [inference]

glutathione transmembrane transporter activity

active transmembrane transporter activity [inference]

primary active transmembrane transporter activity [inference]

ATPase-coupled transmembrane transporter activity [inference]

ABC-type transporter activity

xenobiotic transmembrane transporter activity

ABC-type xenobiotic transporter activity

sulfur compound transmembrane transporter activity [inference]

ABC-type glutathione S-conjugate transporter activity

binding [inference]

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ATP-dependent activity [inference]

ATPase-coupled transmembrane transporter activity [inference]

ABC-type transporter activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

multidrug resistance-associated

Functional Category

J: Translation, ribosomal structure and biogenesis
K: Transcription
T: Signal transduction mechanisms

Displaying **all 3** entries
Gene Ontology
ABC-type transporter activity
ATP binding
nucleotide binding

Displaying **all 6** entries
InterPro
AAA+ ATPase domain
ABC transporter type 1, transmembrane domain superfamily
ABC transporter type 1, transmembrane domain
ABC transporter-like, ATP-binding domain
ABC transporter-like, conserved site
P-loop containing nucleoside triphosphate hydrolase

Rhea

RHEA:19121

H₂O + ATP + an S-substituted glutathione

H⁺ + phosphate + ADP + an S-substituted glutathione

Enzyme

7.6.2.3

PMID

RHEA:33147

H₂O + ATP + daunorubicin

H⁺ + phosphate + ADP + daunorubicin

Enzyme

7.6.2.2

PMID

9281595

Ortholog

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Species	Gene ID	Orthologous MAtrix
Homo sapiens	4363	HUMAN26860
Mus musculus	17250	MOUSE17577
Rattus norvegicus	24565	RATNO03566
Canis lupus familiaris	403453	CANLF16540
Pan troglodytes	453952	PANTR11829
Macaca mulatta	717857	MACMU27250
Equus caballus	791240	HORSE07711
Danio rerio	100002010	DANRE30614
Monodelphis domestica	100023220	MONDO29162
Ornithorhynchus anatinus	100087202	ORNAN16982

GlyTouCan

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LM-GlycoRepo

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OrthoDB (Group)

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