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Standards Ontologies Notations
cytochrome P450 family 17 subfamily A member 1

Summary
Gene Symbol
  • CYP17A1
Organism
Bos taurus (domestic cattle)
NCBI Gene
281739
KEGG Gene ID
bta:281739
PubChem
281739
Annotation
Keyword
  • Heme
  • Lipid metabolism
  • Lyase
  • Membrane
  • Microsome
  • Monooxygenase
  • Reference proteome
  • Steroidogenesis
Proteins
Displaying 1 entry
UniProt Protein Name
P05185
  • 17-alpha-hydroxyprogesterone aldolase
  • CYPXVII
  • Cytochrome P450 17A1
  • Cytochrome P450-C17
  • Steroid 17-alpha-monooxygenase
Annotation information from UniProt.
Gene Ontology (GO)
Displaying all 2 entries
GO Term Evidence Code PMID
hormone biosynthetic process
progesterone metabolic process
GO Hierarchy
Gene Ontology information from NCBI Gene and UniProt.
OrthoDB (Group)
Group level
Eukaryota
Group Name
cytochrome
Functional Category
  • C: Energy production and conversion
  • Q: Secondary metabolites biosynthesis, transport and catabolism
  • T: Signal transduction mechanisms
Displaying all 6 entries
Gene Ontology
heme binding
iron ion binding
metal ion binding
monooxygenase activity
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
oxidoreductase activity
Displaying all 4 entries
InterPro
Cytochrome P450 superfamily
Cytochrome P450, E-class, group I
Cytochrome P450, conserved site
Cytochrome P450
KEGG BRITE Database
Orthology
K00512
Name
steroid 17alpha-monooxygenase / 17alpha-hydroxyprogesterone deacetylase [EC:1.14.14.19 1.14.14.32]
References
Rhea

RHEA:50236

O2 + pregnenolone
H2O + H+ + 17α-hydroxypregnenolone
Enzyme
PMID

RHEA:50244

O2 + 17α-hydroxypregnenolone
H2O + H+ + 3β-hydroxyandrost-5-en-17-one + acetate
Enzyme
PMID

RHEA:65760

O2 + a C21-steroid
a 17α-hydroxy-C21-steroid + H2O + H+
Enzyme
PMID

RHEA:14753

O2 + 17α-hydroxyprogesterone
H2O + H+ + androst-4-ene-3,17-dione + acetate
Enzyme
PMID

RHEA:46308

O2 + progesterone
H2O + H+ + 17α-hydroxyprogesterone
Enzyme
PMID
Ortholog
Displaying entries 1 - 10 of 113 in total
Species Gene ID OrthoDB Alliance of Genome Resources Orthologous MAtrix
1586 HUMAN02789
13074 MOUSE26570
25146 RATNO17926
399692 DANRE05649
403330 9823_0:0040ee PIGXX08420
450141 PANTR01466
477807 CANLF11436
493967 FELCA26692
493968 9940_0:00491b SHEEP11572
100034232 HORSE16960
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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: December 9, 2024