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integrin subunit beta 1

Summary

Gene Symbol

ITGB1

Organism

Bos taurus (domestic cattle)

External Links

NCBI Gene: 281876
PubChem: 281876

Annotation

Keyword

Acetylation
Alternative splicing
Calcium
Cell adhesion
Cell junction
Cell membrane
Cell projection
Disulfide bond
EGF-like domain
Endosome
Glycoprotein
Host cell receptor for virus entry
Host-virus interaction
Integrin
Isopeptide bond
Magnesium
Metal-binding
Myogenesis
Phosphoprotein
Reference proteome
Repeat
Signal
Transmembrane helix
Ubl conjugation

Proteins

Displaying 1 entry
UniProt	Protein Name
P53712	Fibronectin receptor subunit beta VLA-4 subunit beta

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **11 - 14** of 14 in total

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GO Term	Evidence Code	PMID
myoblast differentiation
negative regulation of vasoconstriction
cellular response to low-density lipoprotein particle stimulus
muscle organ development

GO Hierarchy

biological process

cellular process [inference]

syncytium formation [inference]

syncytium formation by plasma membrane fusion [inference]

myoblast fusion

cell adhesion [inference]

cell-substrate adhesion [inference]

cell-matrix adhesion

signal transduction [inference]

cell surface receptor signaling pathway [inference]

integrin-mediated signaling pathway

vesicle-mediated transport [inference]

endocytosis [inference]

receptor-mediated endocytosis [inference]

receptor internalization

cellular developmental process [inference]

cell differentiation [inference]

myoblast differentiation

cell motility [inference]

cell migration

cellular response to stimulus [inference]

cellular response to lipoprotein particle stimulus [inference]

cellular response to low-density lipoprotein particle stimulus

cell-cell fusion [inference]

syncytium formation by plasma membrane fusion [inference]

myoblast fusion

multicellular organismal process [inference]

system process [inference]

circulatory system process [inference]

vascular process in circulatory system [inference]

blood vessel diameter maintenance [inference]

regulation of vasoconstriction [inference]

negative regulation of vasoconstriction

developmental process [inference]

anatomical structure formation involved in morphogenesis [inference]

syncytium formation [inference]

syncytium formation by plasma membrane fusion [inference]

myoblast fusion

anatomical structure development [inference]

animal organ development [inference]

muscle organ development

muscle structure development [inference]

muscle organ development

cellular developmental process [inference]

cell differentiation [inference]

myoblast differentiation

response to stimulus [inference]

response to endogenous stimulus [inference]

response to lipoprotein particle [inference]

cellular response to low-density lipoprotein particle stimulus

response to chemical [inference]

response to organic substance [inference]

response to organonitrogen compound [inference]

response to lipoprotein particle [inference]

cellular response to low-density lipoprotein particle stimulus

response to nitrogen compound [inference]

response to organonitrogen compound [inference]

response to lipoprotein particle [inference]

cellular response to low-density lipoprotein particle stimulus

cellular response to stimulus [inference]

cellular response to lipoprotein particle stimulus [inference]

cellular response to low-density lipoprotein particle stimulus

localization [inference]

establishment of localization [inference]

transport [inference]

vesicle-mediated transport [inference]

endocytosis [inference]

receptor-mediated endocytosis [inference]

receptor internalization

import into cell [inference]

endocytosis [inference]

receptor-mediated endocytosis [inference]

receptor internalization

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of catabolic process [inference]

regulation of collagen catabolic process

regulation of collagen metabolic process [inference]

regulation of collagen catabolic process

regulation of localization [inference]

regulation of cellular localization [inference]

regulation of protein localization [inference]

positive regulation of protein localization [inference]

positive regulation of protein localization to cell periphery [inference]

positive regulation of protein localization to plasma membrane

positive regulation of protein localization to membrane [inference]

positive regulation of protein localization to plasma membrane

regulation of protein localization to cell periphery [inference]

regulation of protein localization to plasma membrane [inference]

positive regulation of protein localization to plasma membrane

positive regulation of protein localization to cell periphery [inference]

positive regulation of protein localization to plasma membrane

regulation of protein localization to membrane [inference]

regulation of protein localization to plasma membrane [inference]

positive regulation of protein localization to plasma membrane

positive regulation of protein localization to membrane [inference]

positive regulation of protein localization to plasma membrane

regulation of locomotion [inference]

positive regulation of locomotion [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration

regulation of cell motility [inference]

regulation of cell migration [inference]

positive regulation of cell migration

positive regulation of cell motility [inference]

positive regulation of cell migration

positive regulation of biological process [inference]

positive regulation of locomotion [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration

positive regulation of cellular process [inference]

positive regulation of protein localization [inference]

positive regulation of protein localization to cell periphery [inference]

positive regulation of protein localization to plasma membrane

positive regulation of protein localization to membrane [inference]

positive regulation of protein localization to plasma membrane

positive regulation of cell motility [inference]

positive regulation of cell migration

negative regulation of biological process [inference]

negative regulation of multicellular organismal process [inference]

negative regulation of vasoconstriction

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

integrin-mediated signaling pathway

positive regulation of cellular process [inference]

positive regulation of protein localization [inference]

positive regulation of protein localization to cell periphery [inference]

positive regulation of protein localization to plasma membrane

positive regulation of protein localization to membrane [inference]

positive regulation of protein localization to plasma membrane

positive regulation of cell motility [inference]

positive regulation of cell migration

regulation of cellular localization [inference]

regulation of protein localization [inference]

positive regulation of protein localization [inference]

positive regulation of protein localization to cell periphery [inference]

positive regulation of protein localization to plasma membrane

positive regulation of protein localization to membrane [inference]

positive regulation of protein localization to plasma membrane

regulation of protein localization to cell periphery [inference]

regulation of protein localization to plasma membrane [inference]

positive regulation of protein localization to plasma membrane

positive regulation of protein localization to cell periphery [inference]

positive regulation of protein localization to plasma membrane

regulation of protein localization to membrane [inference]

regulation of protein localization to plasma membrane [inference]

positive regulation of protein localization to plasma membrane

positive regulation of protein localization to membrane [inference]

positive regulation of protein localization to plasma membrane

regulation of cell motility [inference]

regulation of cell migration [inference]

positive regulation of cell migration

positive regulation of cell motility [inference]

positive regulation of cell migration

regulation of multicellular organismal process [inference]

regulation of system process [inference]

regulation of blood circulation [inference]

regulation of vasoconstriction [inference]

negative regulation of vasoconstriction

negative regulation of multicellular organismal process [inference]

negative regulation of vasoconstriction

regulation of biological quality [inference]

regulation of anatomical structure size [inference]

regulation of tube size [inference]

regulation of tube diameter [inference]

blood vessel diameter maintenance [inference]

regulation of vasoconstriction [inference]

negative regulation of vasoconstriction

Displaying entries **6 - 10** of 11 in total

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GO Term	Evidence Code	PMID
ruffle membrane
integrin complex	IEA	30032202
cell surface	IEA	30032202
melanosome
lamellipodium

GO Hierarchy

cellular component

protein-containing complex [inference]

receptor complex [inference]

plasma membrane signaling receptor complex [inference]

integrin complex

integrin alpha9-beta1 complex

protein complex involved in cell adhesion [inference]

integrin complex

integrin alpha9-beta1 complex

membrane protein complex [inference]

plasma membrane protein complex [inference]

plasma membrane signaling receptor complex [inference]

integrin complex

integrin alpha9-beta1 complex

cellular anatomical entity [inference]

cell surface

plasma membrane [inference]

sarcolemma

plasma membrane region [inference]

cell projection membrane [inference]

ruffle membrane

cell junction [inference]

synapse

anchoring junction [inference]

cell-substrate junction [inference]

focal adhesion

leading edge membrane [inference]

ruffle membrane

cell projection [inference]

plasma membrane bounded cell projection [inference]

lamellipodium

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

recycling endosome

pigment granule [inference]

melanosome

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

recycling endosome

pigment granule [inference]

melanosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

recycling endosome

pigment granule [inference]

melanosome

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
integrin binding	IEA	30032202
C-X3-C chemokine binding	IEA	30032202
collagen binding involved in cell-matrix adhesion	IEA	30032202
integrin binding involved in cell-matrix adhesion
metal ion binding

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

fibronectin binding

signaling receptor binding [inference]

integrin binding

integrin binding involved in cell-matrix adhesion

enzyme binding [inference]

kinase binding [inference]

protein kinase binding

cytokine binding [inference]

chemokine binding [inference]

C-X3-C chemokine binding

laminin binding

protein dimerization activity [inference]

protein heterodimerization activity

cell adhesion molecule binding [inference]

integrin binding

integrin binding involved in cell-matrix adhesion

cell adhesion mediator activity [inference]

cell-matrix adhesion mediator activity [inference]

exogenous protein binding [inference]

virus receptor activity

ion binding [inference]

cation binding [inference]

metal ion binding

protein-containing complex binding [inference]

integrin binding

integrin binding involved in cell-matrix adhesion

collagen binding [inference]

collagen binding involved in cell-matrix adhesion

extracellular matrix binding [inference]

laminin binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Integrin beta

Functional Category

E: Amino acid transport and metabolism
K: Transcription
T: Signal transduction mechanisms

Displaying **all 5** entries
Gene Ontology
cell adhesion mediated by integrin
cell migration
cell-matrix adhesion
integrin binding
integrin-mediated signaling pathway

Displaying **all 7** entries
InterPro
Integrin beta subunit, VWA domain
Integrin beta subunit, cytoplasmic domain
Integrin beta subunit, tail
Integrin beta subunit
Integrin beta tail domain superfamily
Integrin domain superfamily
von Willebrand factor A-like domain superfamily

Ortholog

Displaying entries **21 - 30** of 98 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Nomascus leucogenys	100595108			NOMLE14524
Loxodonta africana	100664978			LOXAF03312
Oreochromis niloticus	100703183			ORENI75092
Cavia porcellus	100719502			CAVPO15275
Cricetulus griseus	100763033			CRIGR17964
Otolemur garnettii	100955745			OTOGA14502
Pan paniscus	100992059			PANPA04588
Papio anubis	101005052			PAPAN03033
Saimiri boliviensis boliviensis	101040620			SAIBB29997
Takifugu rubripes	101067303			TAKRU02422

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Last updated: December 9, 2024