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glycerol-3-phosphate dehydrogenase 2

Summary

Gene Symbol

GPD2

Organism

Homo sapiens (human)

External Links

NCBI Gene

2820

HGNC

4456

KEGG Gene ID

hsa:2820

PubChem

2820

Alliance of Genome Resources

HGNC:4456

Annotation

Keyword

Alternative splicing
Calcium
Direct protein sequencing
FAD
Metal-binding
Mitochondrion
Oxidoreductase
Phosphoprotein
Reference proteome
Repeat
Transit peptide

Proteins

Displaying 1 entry
UniProt	Protein Name
P43304	mitohondrial glycerophosphate dehydrogenase gene mtGPD

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 3** entries
GO Term	Evidence Code	PMID
glycerol-3-phosphate metabolic process	IEA
glycerophosphate shuttle	TAS
glycerol catabolic process	IEA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

NAD metabolic process [inference]

NADH metabolic process [inference]

NADH oxidation [inference]

glycerophosphate shuttle

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NAD metabolic process [inference]

NADH metabolic process [inference]

NADH oxidation [inference]

glycerophosphate shuttle

purine-containing compound metabolic process [inference]

purine nucleotide metabolic process [inference]

NAD metabolic process [inference]

NADH metabolic process [inference]

NADH oxidation [inference]

glycerophosphate shuttle

pyridine-containing compound metabolic process [inference]

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NAD metabolic process [inference]

NADH metabolic process [inference]

NADH oxidation [inference]

glycerophosphate shuttle

organonitrogen compound metabolic process [inference]

purine-containing compound metabolic process [inference]

purine nucleotide metabolic process [inference]

NAD metabolic process [inference]

NADH metabolic process [inference]

NADH oxidation [inference]

glycerophosphate shuttle

pyridine-containing compound metabolic process [inference]

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NAD metabolic process [inference]

NADH metabolic process [inference]

NADH oxidation [inference]

glycerophosphate shuttle

catabolic process [inference]

small molecule catabolic process [inference]

alcohol catabolic process [inference]

polyol catabolic process [inference]

alditol catabolic process [inference]

glycerol catabolic process

organic substance catabolic process [inference]

carbohydrate catabolic process [inference]

alditol catabolic process [inference]

glycerol catabolic process

organic hydroxy compound catabolic process [inference]

alcohol catabolic process [inference]

polyol catabolic process [inference]

alditol catabolic process [inference]

glycerol catabolic process

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

NAD metabolic process [inference]

NADH metabolic process [inference]

NADH oxidation [inference]

glycerophosphate shuttle

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NAD metabolic process [inference]

NADH metabolic process [inference]

NADH oxidation [inference]

glycerophosphate shuttle

purine-containing compound metabolic process [inference]

purine nucleotide metabolic process [inference]

NAD metabolic process [inference]

NADH metabolic process [inference]

NADH oxidation [inference]

glycerophosphate shuttle

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

NAD metabolic process [inference]

NADH metabolic process [inference]

NADH oxidation [inference]

glycerophosphate shuttle

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NAD metabolic process [inference]

NADH metabolic process [inference]

NADH oxidation [inference]

glycerophosphate shuttle

alditol phosphate metabolic process [inference]

glycerol-3-phosphate metabolic process

organophosphate metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

NAD metabolic process [inference]

NADH metabolic process [inference]

NADH oxidation [inference]

glycerophosphate shuttle

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NAD metabolic process [inference]

NADH metabolic process [inference]

NADH oxidation [inference]

glycerophosphate shuttle

alditol phosphate metabolic process [inference]

glycerol-3-phosphate metabolic process

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

NAD metabolic process [inference]

NADH metabolic process [inference]

NADH oxidation [inference]

glycerophosphate shuttle

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NAD metabolic process [inference]

NADH metabolic process [inference]

NADH oxidation [inference]

glycerophosphate shuttle

purine-containing compound metabolic process [inference]

purine nucleotide metabolic process [inference]

NAD metabolic process [inference]

NADH metabolic process [inference]

NADH oxidation [inference]

glycerophosphate shuttle

pyridine-containing compound metabolic process [inference]

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NAD metabolic process [inference]

NADH metabolic process [inference]

NADH oxidation [inference]

glycerophosphate shuttle

cellular ketone metabolic process [inference]

glycerophosphate shuttle

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

NAD metabolic process [inference]

NADH metabolic process [inference]

NADH oxidation [inference]

glycerophosphate shuttle

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NAD metabolic process [inference]

NADH metabolic process [inference]

NADH oxidation [inference]

glycerophosphate shuttle

purine-containing compound metabolic process [inference]

purine nucleotide metabolic process [inference]

NAD metabolic process [inference]

NADH metabolic process [inference]

NADH oxidation [inference]

glycerophosphate shuttle

pyridine-containing compound metabolic process [inference]

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NAD metabolic process [inference]

NADH metabolic process [inference]

NADH oxidation [inference]

glycerophosphate shuttle

primary metabolic process [inference]

carbohydrate metabolic process [inference]

carbohydrate catabolic process [inference]

alditol catabolic process [inference]

glycerol catabolic process

alditol metabolic process [inference]

glycerol metabolic process [inference]

glycerol catabolic process

alditol catabolic process [inference]

glycerol catabolic process

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

NAD metabolic process [inference]

NADH metabolic process [inference]

NADH oxidation [inference]

glycerophosphate shuttle

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NAD metabolic process [inference]

NADH metabolic process [inference]

NADH oxidation [inference]

glycerophosphate shuttle

small molecule metabolic process [inference]

alcohol metabolic process [inference]

polyol metabolic process [inference]

alditol metabolic process [inference]

glycerol metabolic process [inference]

glycerol catabolic process

alditol catabolic process [inference]

glycerol catabolic process

polyol catabolic process [inference]

alditol catabolic process [inference]

glycerol catabolic process

primary alcohol metabolic process [inference]

glycerophosphate shuttle

alcohol catabolic process [inference]

polyol catabolic process [inference]

alditol catabolic process [inference]

glycerol catabolic process

cellular ketone metabolic process [inference]

glycerophosphate shuttle

small molecule catabolic process [inference]

alcohol catabolic process [inference]

polyol catabolic process [inference]

alditol catabolic process [inference]

glycerol catabolic process

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

NAD metabolic process [inference]

NADH metabolic process [inference]

NADH oxidation [inference]

glycerophosphate shuttle

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NAD metabolic process [inference]

NADH metabolic process [inference]

NADH oxidation [inference]

glycerophosphate shuttle

organic substance metabolic process [inference]

carbohydrate metabolic process [inference]

carbohydrate catabolic process [inference]

alditol catabolic process [inference]

glycerol catabolic process

alditol metabolic process [inference]

glycerol metabolic process [inference]

glycerol catabolic process

alditol catabolic process [inference]

glycerol catabolic process

organophosphate metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

NAD metabolic process [inference]

NADH metabolic process [inference]

NADH oxidation [inference]

glycerophosphate shuttle

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NAD metabolic process [inference]

NADH metabolic process [inference]

NADH oxidation [inference]

glycerophosphate shuttle

alditol phosphate metabolic process [inference]

glycerol-3-phosphate metabolic process

cellular ketone metabolic process [inference]

glycerophosphate shuttle

carbohydrate derivative metabolic process [inference]

glycerophosphate shuttle

alditol phosphate metabolic process [inference]

glycerol-3-phosphate metabolic process

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

NAD metabolic process [inference]

NADH metabolic process [inference]

NADH oxidation [inference]

glycerophosphate shuttle

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NAD metabolic process [inference]

NADH metabolic process [inference]

NADH oxidation [inference]

glycerophosphate shuttle

purine-containing compound metabolic process [inference]

purine nucleotide metabolic process [inference]

NAD metabolic process [inference]

NADH metabolic process [inference]

NADH oxidation [inference]

glycerophosphate shuttle

pyridine-containing compound metabolic process [inference]

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NAD metabolic process [inference]

NADH metabolic process [inference]

NADH oxidation [inference]

glycerophosphate shuttle

organonitrogen compound metabolic process [inference]

purine-containing compound metabolic process [inference]

purine nucleotide metabolic process [inference]

NAD metabolic process [inference]

NADH metabolic process [inference]

NADH oxidation [inference]

glycerophosphate shuttle

pyridine-containing compound metabolic process [inference]

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NAD metabolic process [inference]

NADH metabolic process [inference]

NADH oxidation [inference]

glycerophosphate shuttle

organic substance catabolic process [inference]

carbohydrate catabolic process [inference]

alditol catabolic process [inference]

glycerol catabolic process

organic hydroxy compound catabolic process [inference]

alcohol catabolic process [inference]

polyol catabolic process [inference]

alditol catabolic process [inference]

glycerol catabolic process

organic hydroxy compound metabolic process [inference]

alcohol metabolic process [inference]

polyol metabolic process [inference]

alditol metabolic process [inference]

glycerol metabolic process [inference]

glycerol catabolic process

alditol catabolic process [inference]

glycerol catabolic process

polyol catabolic process [inference]

alditol catabolic process [inference]

glycerol catabolic process

primary alcohol metabolic process [inference]

glycerophosphate shuttle

alcohol catabolic process [inference]

polyol catabolic process [inference]

alditol catabolic process [inference]

glycerol catabolic process

organic hydroxy compound catabolic process [inference]

alcohol catabolic process [inference]

polyol catabolic process [inference]

alditol catabolic process [inference]

glycerol catabolic process

cellular process [inference]

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

NAD metabolic process [inference]

NADH metabolic process [inference]

NADH oxidation [inference]

glycerophosphate shuttle

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NAD metabolic process [inference]

NADH metabolic process [inference]

NADH oxidation [inference]

glycerophosphate shuttle

purine-containing compound metabolic process [inference]

purine nucleotide metabolic process [inference]

NAD metabolic process [inference]

NADH metabolic process [inference]

NADH oxidation [inference]

glycerophosphate shuttle

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

NAD metabolic process [inference]

NADH metabolic process [inference]

NADH oxidation [inference]

glycerophosphate shuttle

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NAD metabolic process [inference]

NADH metabolic process [inference]

NADH oxidation [inference]

glycerophosphate shuttle

alditol phosphate metabolic process [inference]

glycerol-3-phosphate metabolic process

organophosphate metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

NAD metabolic process [inference]

NADH metabolic process [inference]

NADH oxidation [inference]

glycerophosphate shuttle

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NAD metabolic process [inference]

NADH metabolic process [inference]

NADH oxidation [inference]

glycerophosphate shuttle

alditol phosphate metabolic process [inference]

glycerol-3-phosphate metabolic process

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

NAD metabolic process [inference]

NADH metabolic process [inference]

NADH oxidation [inference]

glycerophosphate shuttle

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NAD metabolic process [inference]

NADH metabolic process [inference]

NADH oxidation [inference]

glycerophosphate shuttle

purine-containing compound metabolic process [inference]

purine nucleotide metabolic process [inference]

NAD metabolic process [inference]

NADH metabolic process [inference]

NADH oxidation [inference]

glycerophosphate shuttle

pyridine-containing compound metabolic process [inference]

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NAD metabolic process [inference]

NADH metabolic process [inference]

NADH oxidation [inference]

glycerophosphate shuttle

cellular ketone metabolic process [inference]

glycerophosphate shuttle

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

NAD metabolic process [inference]

NADH metabolic process [inference]

NADH oxidation [inference]

glycerophosphate shuttle

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NAD metabolic process [inference]

NADH metabolic process [inference]

NADH oxidation [inference]

glycerophosphate shuttle

purine-containing compound metabolic process [inference]

purine nucleotide metabolic process [inference]

NAD metabolic process [inference]

NADH metabolic process [inference]

NADH oxidation [inference]

glycerophosphate shuttle

pyridine-containing compound metabolic process [inference]

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NAD metabolic process [inference]

NADH metabolic process [inference]

NADH oxidation [inference]

glycerophosphate shuttle

Displaying **all 3** entries
GO Term	Evidence Code	PMID
mitochondrial inner membrane	TAS
mitochondrion	IBA IDA
glycerol-3-phosphate dehydrogenase complex

GO Hierarchy

cellular component

protein-containing complex [inference]

catalytic complex [inference]

oxidoreductase complex [inference]

glycerol-3-phosphate dehydrogenase complex

cellular anatomical entity [inference]

membrane [inference]

organelle membrane [inference]

organelle inner membrane [inference]

mitochondrial inner membrane

mitochondrial membrane [inference]

mitochondrial inner membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

Displaying **all 2** entries
GO Term	Evidence Code	PMID
calcium ion binding	IEA
glycerol-3-phosphate dehydrogenase (quinone) activity	IDA TAS	9070847

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

oxidoreductase activity, acting on CH-OH group of donors [inference]

oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor [inference]

glycerol-3-phosphate dehydrogenase (quinone) activity

binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

calcium ion binding

Gene Ontology information from NCBI Gene and UniProt.

Human Protein Atlas

ENSG00000115159

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

KEGG BRITE Database

Orthology

K00111

Name

glycerol-3-phosphate dehydrogenase [EC:1.1.5.3]

References

Rhea

a quinone + sn-glycerol 3-phosphate

a quinol + dihydroxyacetone phosphate

Enzyme

1.1.5.3

PMID

sn-glycerol 3-phosphate + ubiquinone-8

dihydroxyacetone phosphate + ubiquinol-8

Enzyme

1.1.5.3

sn-glycerol 3-phosphate

dihydroxyacetone phosphate

Enzyme

1.1.5.3

sn-glycerol 3-phosphate

dihydroxyacetone phosphate

Enzyme

1.1.5.3

Disease

Disease Ontology

Displaying entries **11 - 20** of 23 in total

« First

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DO ID	Disease Name	Source
DOID:3070	high grade glioma	DisGeNET
DOID:3071	gliosarcoma	DisGeNET
DOID:3620	central nervous system cancer	DisGeNET
DOID:3748	esophagus squamous cell carcinoma	DisGeNET
DOID:3892	insulinoma	DisGeNET
DOID:3963	thyroid gland carcinoma	DisGeNET DisGeNET
DOID:4766	embryoma	DisGeNET
DOID:5076	mixed glioma	DisGeNET
DOID:8927	learning disability	DisGeNET
DOID:9273	citrullinemia	DisGeNET DisGeNET

The Human Phenotype Ontology

Displaying **all 4** entries
HPO ID	HPO Term
HP:0000006	Autosomal dominant inheritance
HP:0000855	Insulin resistance
HP:0003584	Late onset
HP:0005978	Type II diabetes mellitus

Displaying 1 entry
Disease ID	Disease Name
OMIM:125853	type 2 diabetes mellitus

PubChem Disease

MedGen Diseases

Type II diabetes mellitus

OMIM Phenotypes

TYPE 2 DIABETES MELLITUS; T2D

Gene-Disease-Co-Occurrences-in-Literature (PubChem)

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP000605
Gene Name: glycerol-3-phosphate dehydrogenase 2 (mitochondrial)

Ortholog

Displaying entries **1 - 10** of 88 in total

1

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Caenorhabditis elegans	172509	WB:WBGene00012031
Caenorhabditis elegans	190107	WB:WBGene00013049
Drosophila melanogaster	34776	FB:FBgn0028848
Drosophila melanogaster	35689	FB:FBgn0033190
Drosophila melanogaster	47611	FB:FBgn0022160
Ciona intestinalis	100183886		CIOIN03853
Callorhinchus milii	103176409		CALMI10198
Latimeria chalumnae	102361446		LATCH09766
Danio rerio	751628	ZFIN:ZDB-GENE-030131-4869	DANRE39128
Ictalurus punctatus	108273160		ICTPU03523

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Last updated: August 19, 2024